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ethyl anthranilate

Chemical Structure

General Material Information

Preferred name ethyl anthranilate
Trivial Name Ethyl 2-aminobenzoate
Short Description ethyl o-aminobenzoate
Formula C9 H11 N O2
CAS Number 87-25-2
FEMA Number 2421
Flavis Number 9.716
ECHA Number 201-735-1
FDA UNII 38Y050IUE4
Nikkaji Number J4.276E
Beilstein Number 0878874
MDL MFCD00007711
COE Number 251
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1535 ethyl anthranilate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 87-25-2 ; ETHYL ANTHRANILATE
Synonyms
  • 2-amino-benzoic acid ethyl ester
  • 2-aminobenzoic acid ethyl ester
  • anaesthesine
  • anthranilic acid ethyl ester
  • benzoic acid, 2-amino-, ethyl ester
  • benzoic acid, amino-, ethyl ester
  • 2-carboethoxyaniline
  • 2-( ethoxycarbonyl) aniline
  • o-( ethoxycarbonyl) aniline
  • ortho-( ethoxycarbonyl) aniline
  • ethyl 2-aminobenzoate
  • ethyl anthranilate FCC
  • ethyl o-aminobenzoate
  • ethyl ortho-aminobenzoate
  • Anthranilic acid, ethyl ester
  • o-(Ethoxycarbonyl)aniline
  • 2-Carboethoxyaniline
  • 2-Aminobenzoic acid ethyl ester
  • 2-(Ethoxycarbonyl)aniline
  • (2-(Ethoxycarbonyl)phenyl)amine
  • NSC 4146

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

ethyl 2-aminobenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:87-25-2
Pubchem (cid):6877
Pubchem (sid):134971560
Pherobase:View
Publications by Info
anthranilate derivatives

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33589
FooDB:FDB011666
Export Tariff Code:2921.51.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Formulations/Preparations:
grades: technical: fcc

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 165.19206237793
Specific gravity @ 25 °C
Pounds per Gallon 9.295 to 9.311
Refractive Index 1.563 to 1.566 @ 20 °C
Melting Point 13 to 14°C @ 760 mm Hg
Boiling Point 129 to 130°C @ 9 mm Hg
Boiling Point 145 to 147°C @ 15 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 0.01 mmHg @ 25 °C
Vapor Density 5.7
Flash Point TCC Value 110 °C TCC
logP (o/w) 2.57
Solubility
alcohol Yes
fixed oils Yes
propylene glycol Yes
water, 413.6 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Odor Type: Floral
sweet, floral, grape, orangeflower, wintergreen
Odor strength medium
Substantivity 28 hour(s) at 100.00 %
Luebke, William tgsc, (1996) At 100.00 %. sweet floral grape orangeblossom wintergreen
Flavor Type: Fruity
sweet, fruity, floral, minty, wintergreen
Luebke, William tgsc, (1996) Sweet fruity floral minty wintergreen
Compatible with cuminyl alcohol. Can be used in coconut, root beer, cola, apricot, grape and peach flavors. Fruity

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 3750 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 759, 1976.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 759, 1976.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for ethyl anthranilate usage levels up to:
8.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 12.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 39.00 (μg/capita/day)
Threshold of Concern:1800 (μg/person/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -23.00000
beverages(nonalcoholic): -5.90000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -79.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -7.60000
fruit ices: -7.60000
gelatins / puddings: -14.00000
granulated sugar: --
gravies: --
hard candy: -19.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 84, (FGE.84)[1] - Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):87-25-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6877
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
ethyl 2-aminobenzoate
Chemidplus:0000087252
EPA/NOAA CAMEO:hazardous materials
RTECS:DG2448000 for cas# 87-25-2