Musk tetralin (tonalide) is a synthetic musk compound known for its medium-strength amber and musky odor widely used in fragrances and certain flavor applications.
The preferred CAS number of musk tetralin (tonalide) is CAS 21145-77-7. CAS number 1506-02-1 is also used for tonalide and is has also a deleted CAS number 131433-13-1.
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| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2914.39.0000 |
| ChemSpider: | View |
| Preferred name | musk tetralin |
| Trivial Name | 1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone |
| Short Description | tonalid (PFW) |
| Formula | C18 H26 O |
| CAS Number | 21145-77-7 |
| CAS Number | 1506-02-1 |
| Deleted CAS Number | 131433-13-1 |
| FEMA Number | 4879 |
| ECHA Number | 216-133-4 |
| FDA UNII | Search |
| Nikkaji Number | J16.863G |
| xLogP3-AA | 5.30 (est) |
| NMR Predictor | External link |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| Synonyms |
|
| Material listed in food chemical codex | No |
| Molecular weight | 258.40441894531 |
| Melting Point | 53 to 54°C @ 760 mm Hg |
| Vapor Pressure | 2.8E-5 mmHg @ 25 °C |
| Flash Point TCC Value | 100 °C TCC |
| logP (o/w) | 5.063 est |
| Shelf life | 36 months (or longer if stored properly.) |
| Storage notes | Store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Solubility | |
| alcohol | Yes |
| dipropylene glycol | Yes |
| water, 0.2879 mg/L @ 25 °C (est) | Yes |
| water | No |
| Stability | |
| detergent | Unspecified |
| soap | Unspecified |
| Odor Type: Musk | |
| sweet, amber, ambrette, fruity, musk, powdery | |
| Odor strength | medium , recommend smelling in a 10.00 % solution or less |
| Substantivity | > 400 hour(s) at 10.00 % in dipropylene glycol |
| Luebke, William tgsc, (1985) | At 10.00 % in isopropyl myristate. strong sweet amber ambrette fruity musk powdery |
| Flavor Type: Amber | |
| amber, ambrette, soapy, fruity, musk, sweet, cloth laundered cloth, powdery, aldehydic, fatty | |
| Luebke, William tgsc, (1985) | Amber ambrette soapy fruity musk sweet laundered cloth powdery aldehydic fatty |
| Applications | |
| Odor purposes | Acacia , Allspice , Ambergris , Ambrette oil replacer , Amyris , Angelica , Animal , Cabreuva wood , Cassia , Cassia blossom , Cedar forest , Christmas , Clean linen , Clove blossom , Country meadow , Cyclamen , Fern , Fir balsam , Fir needle oil replacer , Flouve blossom , Foliage , Forest , Frangipani plumeria , Ginger white ginger , Guaiacwood , Habuba , Hawthorn , Heather , Heliotrope , Hollyberry , Hugonia , Incense , Iris blossom , Kewda , Lavender , Leather , Lemon , Lily , Lily of the valley , Magnolia , Maja , Moss , Musk , New car , Oakwood , Ocean sea , Petunia , Phlox , Powder , Rain , Rose white rose , Sandalwood , Spice , Spicewood , Sweet grass , Tobacco , Tonka bean , Vanilla , Verbena , Woodruff , Woody |
| Flavoring purposes | Angelica , Guaiacwood |
| Other purposes | Dusty , Fantasy blends |
| Cosmetic purposes | Fragrance |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn N - Harmful, Dangerous for the environment. | |
| R 22 - Harmful if swallowed. R 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Signal word | Warning |
| Hazard statement(s) | |
| H302 - Harmful if swallowed H400 - Very toxic to aquatic life H410 - Very toxic to aquatic life with long lasting effects | |
| Precautionary statement(s) | |
| P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P273 - Avoid release to the environment. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P330 - Rinse mouth. P391 - Collect spillage. Hazardous to the aquatic environment P501 - Dispose of contents/container in accordance with local/regional/national/international regulations. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 964 mg/kg Dispose of contents/container in accordance with local/regional/national/international regulations. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 7940 mg/kg Dispose of contents/container in accordance with local/regional/national/international regulations | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for musk tetralin usage levels up to: | |||
| 10.0000 % in the fragrance concentrate. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 29 | |||
| Click here to view publication 29 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | - | |
| beverages(nonalcoholic): | 3.00000 | 7.50000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 1.00000 | 2.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | 1.00000 | 2.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 1.00000 | 2.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | 1.00000 | 2.00000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):1506-02-1 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :89440 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WGK Germany:3 |
| 1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone |
| Chemidplus:0001506021 |
| 1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone |
| Chemidplus:021145777 |