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General Material Information

Preferred name musk amberol
Trivial Name (5Z)-cyclohexadec-5-en-1-one
Short Description velvione (Givaudan)
Formula C16 H28 O
CAS Number 37609-25-9
CAS Number 35951-24-7
ECHA Number 253-568-9
FDA UNII O8H24QLZ5Y
Nikkaji Number J208.221G
MDL MFCD00059511
xLogP3-AA 5.60 (est)
NMR Predictor External link
Applications
  • fragrance agents
Synonyms
  • ambretone (Takasago)
  • (5Z)- cyclohexadec-5-en-1-one
  • 5- cyclohexadecen-1-one
  • 5- cyclohexadecenone
  • 15- cyclohexadecenone-1
  • TM-II (Soda)
  • velvione (Givaudan)

Organoleptic Properties

Odor Type: Musk
Odor strength medium , recommend smelling in a 10.00 % solution or less
Substantivity 400 hour(s) at 100.00 %
Luebke, William tgsc, (1988) At 10.00 % in dipropylene glycol. dry powdery musk amber civet
Velvione is an exceptional product: a powdery macrocyclic musk that is powerful, highly substantive and stable, as well as biodegradable. Velvione has a nitro-musk aspect that is not found either in other commonly used macrocyclic musks, nor in polycyclic musks. Velvione is excellent in all applications, including fine fragrance, where it adds a powdery volume and musky softness, and laundry care, where its high substantivity and clean musky note are highly valued. Musky, Powdery, Slightly Animalic
Finds extensive use in many fragrance accords, such as delicate florals, animalic, amber, and musk fragrances. Extremely powerful musky
General comment Natural musk; with vegetable- and ambrette seed notes; slightly animalic

Potential Uses

Odor purposes Aldehydic , Alpine bouquet , Amber , Ambreine , Animal , Balsam , Beeswax absolute replacer , Cabreuva wood , Cassia blossom , Cedar forest , Christmas , Chypre , Cinnamon , Civet , Clean linen , Country meadow , Croton eluteria bark , Cyclamen , Dahlia , Daisy , Daphne , Dillenia , Dogwood , Fern , Floral , Flouve blossom , Foliage , Forest , Ginger white ginger , Guaiacwood , Hay new mown hay , Heather , Herbal , Hugonia , Incense , Ivy , Leather , Moss , Musk , Myrrh , New car , Ocean sea , Opoponax , Oriental , Patchouli , Petunia , Phlox , Pinion , Powder , Privet blossom , Rose , Rose d'orient , Rose moss rose , Rose white rose , Sandalwood , Spice , Spring rain , Sweet grass , Tobacco , Tonka bean , Tulip , Vanilla , Woodruff , Woody
Flavoring purposes Croton eluteria bark , Guaiacwood , Pear prickly pear
Other purposes Clean , Diffusion , Dusty , Enhancer , Liverwort
Cosmetic purposes Perfuming agents

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

(5Z)-cyclohexadec-5-en-1-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:37609-25-9
Pubchem (cid):5362736
Pubchem (sid):135118243
(5E)-cyclohexadec-5-en-1-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:35951-24-7
Pubchem (cid):6506221
Pubchem (sid):43168801
Publications by US Patents
7,943,560 - Cyclopropanated macrocyclic ketones and lactones

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.29.5000
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 236.39836120605
Specific gravity @ 25 °C
Pounds per Gallon 7.755 to 7.772
Refractive Index 1.489 to 1.492 @ 20 °C
Boiling Point 296 to 300°C @ 760 mm Hg
Vapor Pressure 3.3E-5 mmHg @ 25 °C
Flash Point TCC Value 110 °C TCC
logP (o/w) 5.982 est
Solubility
alcohol Yes
water, 0.2997 mg/L @ 25 °C (est) Yes
Stability
alcoholic Good
candles Good
detergent Good
ph = 10 Good
soap Good
toiletries Good
antiperspirant Moderate
ph = 2 Moderate

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 6400 mg/kg

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for musk amberol usage levels up to:
4.0000 % in the fragrance concentrate.
Recommendation for musk amberol flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):37609-25-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5362736
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(5Z)-cyclohexadec-5-en-1-one
Chemidplus:0037609259
(5E)-cyclohexadec-5-en-1-one
Chemidplus:0035951247