cyclododecyl acetate

Cyclododecyl acetate is an organic ester compound with the molecular formula C14H26O2. It appears as a clear substance and is known for its waxy odor profile, augmented by aldehydic and green smoke-like note nuances. This compound is also identified under synonyms such as cyclododecanol acetate and Cyclododecanol, 1-acetate. Its chemical structure encompasses a twelve-membered cycloalkane ring bearing an acetate functional group, which contributes to its scent characteristics. Cyclododecyl acetate is primarily sourced from synthetic chemical processes and is utilized widely in fragrance formulations. For detailed chemical data, this compound is referenced in public databases such as PubChem. It serves as a key ingredient in the development of perfuming agents, offering unique sensory contributions due to its complex odor profile.

Cyclododecyl acetate is not naturally abundant but is synthesized for use in fragrance compositions. Its waxy, aldehydic, and green odor notes make it valuable in perfuming applications where a nuanced and somewhat metallic smoke character is desired. The compound is recognized within fragrance regulatory contexts, including IFRA (Global), which provides guidelines for safe usage levels in perfumery. It is employed exclusively as a fragrance agent, with no approved applications in flavoring according to current standards. The material’s distinct odor components enhance complex scent blends, contributing to product differentiation in the cosmetics industry.

Cyclododecyl acetate has a molecular weight of approximately 226.36 g/mol and a molecular formula of C14H26O2. It exhibits a boiling point range from 282 to 283°C at atmospheric pressure (760 mm Hg), indicating strong intermolecular forces consistent with its large cyclic ester structure. The vapor pressure is very low, approximately 0.003 mmHg at 25°C, contributing to limited volatility under normal conditions. Its estimated log P value of around 5.4 suggests high lipophilicity, favoring solubility in nonpolar organic solvents such as alcohol while showing only slight water solubility (around 0.5 mg/L at 25°C). The flash point measured near 128°C (263°F) indicates relative thermal stability in typical handling environments. These properties influence its formulation behavior, emphasizing the need for suitable solvents and conditions to maintain stability and fragrance delivery performance.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
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(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2915.39.9050
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Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for cyclododecyl acetate flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):6221-92-7

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :80353

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

cyclododecyl acetate

Chemidplus:0006221927