cyclohexyl anthranilate

General Material Information

Preferred name	cyclohexyl anthranilate
Trivial Name	Cyclohexyl anthranilate
Short Description	2-aminobenzoic acid cyclohexyl ester
Formula	C13 H17 N O2
CAS Number	7779-16-0
FEMA Number	2350
Flavis Number	9.722
ECHA Number	231-920-2
FDA UNII	LDE0728B6A
Nikkaji Number	J326.561G
MDL	MFCD00036492
COE Number	257
NMR Predictor	External link
JECFA Food Flavoring	1541 cyclohexyl anthranilate
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	7779-16-0 ; CYCLOHEXYL ANTHRANILATE
Synonyms	2-aminobenzoic acid cyclohexyl ester anthranilic acid cyclohexyl ester anthranilic acid, cyclohexyl ester benzoic acid, 2-amino-, cyclohexyl ester cyclohexyl 2-aminobenzoate

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

	cyclohexyl 2-aminobenzoate
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	7779-16-0
Pubchem (cid):	24510
Pubchem (sid):	134990615

Publications by Info
anthranilate derivatives

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	HMDB37695
FooDB:	FDB016823
Export Tariff Code:	2922.49.3800
ChemSpider:	View

Suppliers

BOC Sciences	Matrix Scientific
Parchem	Penta International
Santa Cruz Biotechnology	Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	219.28388977051
Specific gravity	@ 25 °C
Pounds per Gallon	9.136 to 9.22
Refractive Index	1.559 to 1.569 @ 20 °C
Acid Value	1 max KOH/g
Vapor Pressure	0.001 mmHg @ 20 °C
Vapor Density	1
Flash Point TCC Value	104.44 °C TCC
logP (o/w)	4.151 est
Solubility
alcohol	Yes
water, 4.658 mg/L @ 25 °C (est)	Yes
water	No

Organoleptic Properties

Odor Type: Fruity
neroli, orangeflower, grape
General comment	At 100.00 %. mild neroli orange blossom
Flavor Type: Fruity
grape
General comment	Grape
Used mostly in concord grape flavors.	Grape

Potential Uses

Applications	flavor and fragrance agents
Odor purposes	Floral, Grape, Neroli, Orange blossom, Powder, Woody

Safety Information

Safety information

European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children. S 23 - Do not breath vapour. S 24/25 - Avoid contact with skin and eyes.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for cyclohexyl anthranilate usage levels up to:
	5.0000 % in the fragrance concentrate.

Maximised Survey-derived Daily Intakes (MSDI-EU):		0.0073 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA):		0.007 (μg/capita/day)
Threshold of Concern:		1800 (μg/person/day)
Structure Class:		I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		2.00000	10.00000
beverages(nonalcoholic):		-	10.00000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	3.70000
fruit ices:		-	3.70000
gelatins / puddings:		-	1.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	3.70000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 84, (FGE.84)[1] - Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf

EPI System: View

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):7779-16-0

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :24510

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

cyclohexyl 2-aminobenzoate