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    General Material Information
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filbert pyrazine

Chemical Structure

General Material Information

Preferred name filbert pyrazine
Trivial Name 2-Ethyl-3-methylpyrazine
Short Description 2-ethyl-3-methylpyrazine
Formula C7 H10 N2
CAS Number 15707-23-0
FEMA Number 3155
Flavis Number 14.006
ECHA Number 239-799-8
FDA UNII 9GF35MK66U
Nikkaji Number J45.582B
Beilstein Number 0956775
MDL MFCD00006150
COE Number 548
NMR Predictor External link
JECFA Food Flavoring 768 2-ethyl-3-methylpyrazine
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 15707-23-0 ; 3-ETHYL-2-METHYLPYRAZINE
Synonyms
  • ethyl 3 methyl pyrazine
  • ethyl-2 3-methyl pyrazine
  • 3-ethyl-2-methyl pyrazine
  • 3-ethyl-2-methylpyrazine
  • 2-ethyl-3-methyl pyrazine
  • 2-ethyl-3-methyl pyrazine FCC
  • 2-ethyl-3-methyl pyrazine natural 5% in ethyl alcohol
  • 2-ethyl-3-methyl-1,4-diazine
  • 2-ethyl-3-methylpyrazine
  • 2 ethyl-3-methylpyrazine
  • 2-ethyl-3-methylpyrazine, kosher
  • methyl ethylpyrazine-2,3
  • 2-methyl-3-ethyl pyrazine
  • 2-methyl-3-ethylpyrazine
  • pyrazine, 2-ethyl-3-methyl
  • pyrazine, 2-ethyl-3-methyl-
  • 2-Ethyl-3-methylpyrazine
  • 2-Methyl-3-ethylpyrazine
  • 3-Methyl-2-ethylpyrazine
  • 3-Ethyl-2-methylpyrazine
  • 2-Ethyl-3-methyl-1,4-pyrazine

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

2-ethyl-3-methylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:15707-23-0
Pubchem (cid):27457
Pubchem (sid):134992121
Flavornet:15707-23-0
Publications by US Patents
3,952,024 - Furfurylthioacetone
Certain 2,5-dimethyl-3-thiopyrazines

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB41254
FooDB:FDB021162
Export Tariff Code:2933.59.9500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 122.17070007324
Specific gravity @ 25 °C
Pounds per Gallon 8.138 to 8.221
Refractive Index 1.502 to 1.505 @ 20 °C
Boiling Point 169 to 171°C @ 760 mm Hg
Vapor Pressure 1.689 mmHg @ 25 °C
Vapor Density 4.2
Flash Point TCC Value 58.89 °C TCC
logP (o/w) 1.07
Solubility
alcohol Yes
water, 1.202e+004 mg/L @ 25 °C (est) Yes
water No
Stability
non-discoloring in most media Unspecified
stable in most media Unspecified

Organoleptic Properties

Odor Type: Nutty
nutty, peanut, musty, corn, raw, earthy, bready
General comment At 0.10 % in dipropylene glycol. nutty peanut musty corn raw earthy bread
Mosciano, Gerard P&F 14, No. 6, 47, (1989) Nutty, peanut, musty, corn-like with raw earthy and bready nuances
Flavor Type: Nutty
nutty, peanut, musty, corn, raw, oily
Mosciano, Gerard P&F 14, No. 6, 47, (1989) At 10.00 ppm. Nutty peanut, musty corn-like with raw and oily nuances
Used in nut, peanut, popcorn, cocoa and bread flavors. Nutty
"nutty peanut, musty corn-like with raw and oily nuances" taste at 10 ppm. Similar in odour to 2,3-Diethylpyrazine in that this material has an earthy character. Useful in Roasted Nut, Chocolate, Vegetable and Tobacco flavors. Normal use levels in finished consumer product: 0.05-3 ppm. Council of Europe limits: Foods (5 ppm); Beverages (5 ppm). Nutty
Useful in: brown nuts, brown cereals, brown cocoa, brown coffee, brown others, dairy, savory vegetable, savory meat. Powerful pyrazine character, nutty, roasted
General comment Cereal, nutty, burnt, peanut, musty corn-like, potato, hazelnut

Occurrences

Potential Uses

Applications
Odor purposes Tobacco
Flavoring purposes Bread, Chocolate cocoa, Coffee, Corn, Filbert, Peanut, Popcorn, Potato, Vegetable
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 600 mg/kg
(Moran et al., 1980)

oral-rat LD50 600 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for filbert pyrazine usage levels up to:
0.0500 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 72.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 9.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -3.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -3.00000
fruit ices: -3.00000
gelatins / puddings: -3.00000
granulated sugar: --
gravies: --
hard candy: -3.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -3.00000
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):15707-23-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :27457
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:3
2-ethyl-3-methylpyrazine
Chemidplus:0015707230
RTECS:UQ3335000 for cas# 15707-23-0