cyclododecyl formate

Cyclododecyl formate is an ester derived from cyclododecanol and formic acid, featuring the molecular formula C₁₃H₂₄O₂. It appears as a colorless liquid with a fresh, clean odor reminiscent of sweet woody and clean linen notes. This compound is identified by synonyms such as cyclododecanol formate and cyclofor. Its chemical structure includes a 12-membered cycloalkane ring esterified with formic acid, contributing to its distinctive scent profile. These attributes make it suitable for use as a fragrance ingredient in perfuming applications. For detailed chemical information, it is linked in databases like PubChem. Cyclododecyl formate is typically obtained through the esterification of cyclododecanol, which is sourced from petrochemical feedstocks.

Cyclododecyl formate does not occur naturally in biological systems but is synthesized for fragrance use. It is primarily applied as a scent ingredient in fine fragrances and perfumed products, imparting clean and woody odor notes reminiscent of fresh linen and herbal nuances. The compound exhibits prolonged odor substantivity, making it valuable for long-lasting scent formulations. Regulatory frameworks such as the IFRA Code of Practice (Global) provide guidelines for its safe usage, permitting up to 8% in fragrance concentrates. Its utility is largely confined to perfuming agents and fragrance compositions rather than flavor or food applications due to regulatory restrictions.

Cyclododecyl formate has a molecular weight of approximately 212 g/mol and a molecular formula C₁₃H₂₄O₂. It exhibits low vapor pressure at 25 °C (0.001 mmHg), indicating limited volatility suitable for sustained fragrance release. The boiling point ranges from 294 to 295 °C at standard atmospheric pressure, reflecting thermal stability under typical formulation conditions. Its estimated logP of approximately 5.0 suggests significant lipophilicity, favoring solubility in alcohols but limited water solubility (about 1.868 mg/L at 25 °C estimated). The flash point measured by tag closed cup is 119 °C (248 °F), indicating relative safety from ignition under normal handling. These physical and chemical properties influence its behavior in perfumery, enhancing its fixative effect while maintaining compatibility with typical solvent blends.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
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Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for cyclododecyl formate usage levels up to:
	8.0000 % in the fragrance concentrate.
Recommendation for cyclododecyl formate flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

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EPA Substance Registry Services (TSCA):59052-82-3

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :100936

National Institute of Allergy and Infectious Diseases:Data

cyclododecyl formate

Chemidplus:0059052823