Preferred name | acetaldehyde |
Trivial Name | ethanal |
Short Description | ethylaldehyde |
Formula | C2 H4 O |
CAS Number | 75-07-0 |
FEMA Number | 2003 |
Flavis Number | 5.001 |
ECHA Number | 200-836-8 |
FDA UNII | GO1N1ZPR3B |
Nikkaji Number | J2.388D |
Beilstein Number | 505984 |
MDL | MFCD00006991 |
COE Number | 89 |
xLogP3-AA | -0.30 (est) |
Bio Activity Summary | External link |
NMR Predictor | External link |
JECFA Food Flavoring | 80 acetaldehyde |
FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
Synonyms |
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acetaldehyde | |
NIST Chemistry WebBook: | Search Inchi |
Canada Domestic Sub. List: | 75-07-0 |
Pubchem (cid): | 177 |
Pubchem (sid): | 134970736 |
Flavornet: | 75-07-0 |
Pherobase: | View |
(IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
Videos: | The Periodic Table of Videos |
tgsc: | Atomic Weights use for this web site |
(IUPAC): | Periodic Table of the Elements |
FDA Substances Added to Food (formerly EAFUS): | View |
FDA Indirect Additives used in Food Contact Substances: | View |
CHEBI: | View |
CHEMBL: | View |
UM BBD: | Search |
KEGG (GenomeNet): | C00084 |
HMDB (The Human Metabolome Database): | HMDB00990 |
FooDB: | FDB008297 |
YMDB (Yeast Metabolome Database): | YMDB01369 |
Export Tariff Code: | 2912.12.0000 |
VCF-Online: | VCF Volatile Compounds in Food |
ChemSpider: | View |
Wikipedia: | View |
Formulations/Preparations: grades: commercially avail as 50% aq soln or 99% cp in small steel cylinders.acetaldehyde is avail in usa with following typical specifications: purity, 99.5% min; acidity (as acetic acid), 0.1% max to meet the requirements of the food chemical codex, acetaldehyde must pass an infrared identification test & meet the following specifications: purity, 99.0% min; acidity (as acetic acid) 0.1% max; non-volatile residue, 0.006% max .grade: technical 99% |
Material listed in food chemical codex | Yes |
Molecular weight | 44.053081512451 |
Specific gravity | @ 25 °C |
Pounds per Gallon | 6.449 to 6.532 |
Specific gravity | @ 20 °C |
Pounds per Gallon | 6.465 to 6.548 |
Refractive Index | 1.323 to 1.337 @ 20 °C |
Melting Point | -125 to -123°C @ 760 mm Hg |
Boiling Point | 20 to 21°C @ 760 mm Hg |
Boiling Point | -54 to -53°C @ 15 mm Hg |
Vapor Pressure | 902 mmHg @ 25 °C |
Vapor Density | 1.5 |
Flash Point TCC Value | -40 °C TCC |
logP (o/w) | -0.34 |
Shelf life | 12 months (or longer if stored properly.) |
Storage notes | Refrigerate in tightly sealed containers. |
Solubility | |
acetone | Yes |
alcohol | Yes |
can be salted out of water with calcium chloride | Yes |
ethyl ether | Yes |
water, 1.00E+06 mg/L @ 25 °C (exp) | Yes |
Odor Type: Ethereal | |
pungent, ethereal, aldehydic, fruity, fresh, musty | |
Odor strength | high , recommend smelling in a 0.10 % solution or less |
Substantivity | < 1 hour(s) at 100.00 % |
Luebke, William tgsc, (2017) | At 0.10 % in propylene glycol. pungent ethereal aldehydic fruity |
Mosciano, Gerard P&F 22, No. 4, 75, (1997) | Pungent, etherial, fresh, lifting, penetrating, fruity and musty |
Flavor Type: Pungent | |
pungent, fresh, aldehydic, green | |
General comment | Pungent fresh aldehydic refreshing green |
Mosciano, Gerard P&F 22, No. 4, 75, (1997) | At 10.00 ppm. Pungent, fresh, aldehydic, refreshing and green |
(data available) |
Applications | |
Odor purposes | Currant, Melon, Witch hazel |
Flavoring purposes | Apple, Apricot, Beer, Bread white bread, Butter, Cheese cheddar cheese, Cheese swiss cheese, Corn, Cucumber, Fish, Gooseberry, Grape, Lemon, Orange, Pea green pea, Peach, Pear, Pineapple, Plum, Raspberry, Strawberry, Tomato, Whiskey, Yogurt |
Other purposes | Nail conditioning |
Cosmetic purposes | Fragrance, Nail conditioning |
Preferred SDS: View | |
European information : | |
Most important hazard(s): | |
Xn - Harmful. | |
R 12 - Extremely flammable. R 36/37 - Irritating to eyes and respiratory system. R 40 - Limited evidence of a carcinogenic effect. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 33 - Take precautionary measures against static discharge. S 36/37 - Wear suitable protective clothing and gloves. | |
Hazards identification | |
Classification of the substance or mixture | |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
Eye irritation (Category 2A), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Carcinogenicity (Category 2), H351 Acute aquatic toxicity (Category 3), H402 | |
GHS Label elements, including precautionary statements | |
Signal word | Danger |
Hazard statement(s) | |
H224 - Extremely flammable liquid and vapour H319 - Causes serious eye irritation H335 - May cause respiratory irritation H351 - Suspected of causing cancer H402 - Harmful to aquatic life | |
Precautionary statement(s) | |
P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233 - Keep container tightly closed. P240 - Ground/bond container and receiving equipment. P241 - Use explosion-proof electrical/ventilating/lighting/…/equipment. P242 - Use only non-sparking tools. P243 - Take precautionary measures against static discharge. P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P264 - Wash skin thouroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P273 - Avoid release to the environment. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 - IF exposed or concerned: Get medical advice/attention. P337 + P313 - IF eye irritation persists: Get medical advice/attention. P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction. P403 + P235 - Store in a well-ventilated place. Keep cool. P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
Oral/Parenteral Toxicity: | |
oral-rat LD50 661 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Agents and Actions, A Swiss Journal of Pharmacology. Vol. 4, Pg. 125, 1974. intraperitoneal-rat LDLo 500 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Biological Chemistry. Vol. 152, Pg. 41, 1944. intravenous-rabbit LDLo 300 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 429, 1927. oral-mouse LD50 900 mg/kg Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981. intraperitoneal-mouse LD50 500 mg/kg IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 36, Pg. 101, 1985. intravenous-frog LDLo 800 mg/kg CARDIAC: OTHER CHANGES BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 429, 1927. intratracheal-hamster LD50 96 mg/kg Progress in Experimental Tumor Research. Vol. 24, Pg. 162, 1979. | |
Dermal Toxicity: | |
skin-rabbit LD50 3540 mg/kg Union Carbide Data Sheet. Vol. 12/13/1963 subcutaneous-rat LD50 640 mg/kg BEHAVIORAL: GENERAL ANESTHETIC Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950. subcutaneous-rabbit LDLo 1200 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 429, 1927. subcutaneous-mouse LD50 560 mg/kg BEHAVIORAL: GENERAL ANESTHETIC Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950. | |
Inhalation Toxicity: | |
inhalation-hamster LC50 17000 ppm/4H Progress in Experimental Tumor Research. Vol. 24, Pg. 162, 1979. inhalation-mammal (species unspecified) LC50 20100 mg/m3 BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(7), Pg. 54, 1975. inhalation-mouse LC50 23000 mg/m3/4H Current Toxicology. Vol. 1, Pg. 47, 1993. inhalation-rat LC50 13300 ppm/4H LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT National Technical Information Service. Vol. OTS0534485 inhalation-human TCLo 134 ppm/30M LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES JAMA, Journal of the American Medical Association. Vol. 165, Pg. 1908, 1957. |
Category: | |||
cosmetic and flavor agents | |||
Recommendation for acetaldehyde usage levels up to: | |||
not for fragrance use. | |||
NOEL (No Observed Effect Level): | 125 (mg/kg bw per day) | ||
Structure Class: | I | ||
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
publication number: 3 | |||
Click here to view publication 3 | |||
average usual ppm | average maximum ppm | ||
baked goods: | - | 12.00000 | |
beverages(nonalcoholic): | - | 3.90000 | |
beverages(alcoholic): | - | - | |
breakfast cereal: | - | - | |
cheese: | - | - | |
chewing gum: | 20.00000 | 270.00000 | |
condiments / relishes: | - | - | |
confectionery froastings: | - | - | |
egg products: | - | - | |
fats / oils: | - | - | |
fish products: | - | - | |
frozen dairy: | - | 25.00000 | |
fruit ices: | - | 25.00000 | |
gelatins / puddings: | - | 6.80000 | |
granulated sugar: | - | - | |
gravies: | - | - | |
hard candy: | - | 22.00000 | |
imitation dairy: | - | - | |
instant coffee / tea: | - | - | |
jams / jellies: | - | - | |
meat products: | - | - | |
milk products: | - | - | |
nut products: | - | - | |
other grains: | - | - | |
poultry: | - | - | |
processed fruits: | - | - | |
processed vegetables: | - | - | |
reconstituted vegetables: | - | - | |
seasonings / flavors: | - | - | |
snack foods: | - | - | |
soft candy: | - | - | |
soups: | - | - | |
sugar substitutes: | - | - | |
sweet sauces: | - | - |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 3, Revision 1 (FGE.03Rev1): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated aldehydes, an ester of a hemiacetal and an orthoester of formic acid, from chemical groups 1, 2 & 4 Commission Regulation (EC) No 1565/2000 of 18 July 2000) [1] - Scientific Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)on a request from the Commission View page or View pdf |
Flavouring Group Evaluation 61 (FGE.61): Consideration of aliphatic acyclic acetals evaluated by JECFA (57th meeting) structurally related to acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes, and an orthoester of formic acid evaluated by EFSA in FGE.03 (2004) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 14, Revision 1 (FGE.14Rev1): Phenethyl alcohol, aldehyde, acetals, carboxylic acid and related esters from chemical group 15 and 22 [1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 View page or View pdf |
Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Flavouring Group Evaluation 61, Revision 1 (FGE.61Rev1): Consideration of aliphatic acetals evaluated by JECFA (57th meeting) structurally related to acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes and one orthoester of formic acid evaluated View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species View page or View pdf |
EPI System: View |
EPA-Iris:IRIS |
ClinicalTrials.gov:search |
Daily Med:search |
NIOSH International Chemical Safety Cards:search |
NIOSH Pocket Guide:search |
Chemical Carcinogenesis Research Information System:Search |
AIDS Citations:Search |
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EPA GENetic TOXicology:Search |
EPA Substance Registry Services (TSCA):75-07-0 |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :177 |
National Institute of Allergy and Infectious Diseases:Data |
SCCNFP:opinion |
WISER:UN 1089 |
WGK Germany:1 |
acetaldehyde |
Chemidplus:0000075070 |
EPA/NOAA CAMEO:hazardous materials |
RTECS:75-07-0 |