menthyl isovalerate

General Material Information

Preferred name	menthyl isovalerate
Trivial Name	Menthyl isovalerate
Short Description	p-menth-3-yl isovalerate
Formula	C15 H28 O2
CAS Number	16409-46-4
FEMA Number	2669
Flavis Number	9.455
ECHA Number	240-460-1
FDA UNII	Search
Nikkaji Number	J286.893H
Beilstein Number	3200250
MDL	MFCD00045488
COE Number	450
xLogP3-AA	5.00 (est)
NMR Predictor	External link
JECFA Food Flavoring	432 menthyl isovalerate
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	16409-46-4 ; MENTHYL ISOVALERATE
Synonyms	butanoic acid, 3-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester menth-3-yl isovalerate p- menth-3-yl isovalerate para- menth-3-yl isovalerate menthol isovalerate menthyl 3-menthyl butyrate menthyl 3-menthylbutyrate menthyl 3-methyl butanoate menthyl 3-methylbutanoate menthyl isopentanoate menthyl isovalerianate mentyl isovalerate (1alpha,2beta,5alpha)-3-methyl butanoic acid 5-methyl-2-(1-methyl ethyl) cyclohexyl ester 3-methyl butanoic acid 5-methyl-2-(1-methyl ethyl) cyclohexyl ester 5-methyl-2-(1-methyl ethyl) cyclohexyl 3-methyl butanoate 5-methyl-2-(1-methylethyl)cyclohexyl 3-methylbutanoate (5-methyl-2-propan-2-ylcyclohexyl) 3-methylbutanoate 3-methylbutanoic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester 1-iso propyl-4-methyl cyclohex-2-yl 3-methyl butanoate 1-iso propyl-4-methylcyclohex-2-yl 3-methylbutanoate iso valeric acid, p-menth-3-yl ester validol (5-methyl-2-propan-2-ylcyclohexyl) 3-methylbutanoate Menthol, isovalerate Isovaleric acid, p-menth-3-yl ester

US / EU / FDA / JECFA / FEMA / Scholar / Patents

Google Scholar	Start search
Google Books	Start search
Google Patents	Start search
Perfumer & Flavorists	Start search
EU Patents	Start search
PubMeb	Start search
NCBI	Start search

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	HMDB37211
FooDB:	FDB016218
Export Tariff Code:	2915.60.0000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Suppliers

Advanced Biotech	Bell Flavors & Fragrances
BOC Sciences	Inoue Perfumery
Penta International	Reincke & Fichtner
Sigma-Aldrich	WholeChem
Advanced Biotech. Inc.	Penta International Corporation
WholeChem, LLC

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	240.38656616211
Specific gravity	@ 25 °C
Pounds per Gallon
Boiling Point	260 to 262°C @ 750 mm Hg
Vapor Pressure	0.007 mmHg @ 25 °C
Flash Point TCC Value	110 °C TCC
logP (o/w)	5.555 est
Solubility
alcohol	Yes
water, 0.3057 mg/L @ 25 °C (est)	Yes
water	No

Organoleptic Properties

Odor Type: Fruity
fruity, cooling, sweet, woody
Odor strength	medium
Substantivity	96 hour(s) at 100.00 %
General comment	At 100.00 %. fruity cooling sweet woody
Mosciano, Gerard P&F 15, No. 3, 51, (1990)	Fruity, cooling, sweet and woody
Flavor Type: Fruity
fruity, sweet, tutti frutti
Mosciano, Gerard P&F 15, No. 3, 51, (1990)	At 80.00 ppm. Fruity, sweet, with a tutti frutti background

Occurrences

Potential Uses

Applications	flavor and fragrance agents
Odor purposes	Apple, Apricot, Balsam, Cranberry, Currant black currant, Melon, Mint, Peach, Peppermint, Pineapple, Prune, Valerian
Flavoring purposes	Valerian
Cosmetic purposes	Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
1 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg Food and Chemical Toxicology. Vol. 20, Pg. 735, 1982.
Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg Food and Chemical Toxicology. Vol. 20, Pg. 735, 1982.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for menthyl isovalerate usage levels up to:
	1.0000 % in the fragrance concentrate.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		-	18.00000
beverages(nonalcoholic):		-	5.00000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	2.90000
fruit ices:		-	2.90000
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	7.40000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-