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2-ethoxythiazole

Chemical Structure

General Material Information

Preferred name 2-ethoxythiazole
Trivial Name 2-Ethoxythiazole
Short Description thiazole, 2-ethoxy-
Formula C5 H7 N O S
CAS Number 15679-19-3
FEMA Number 3340
Flavis Number 15.021
ECHA Number 239-760-5
FDA UNII Q3O421Q24K
Nikkaji Number J248.729B
MDL MFCD00055026
COE Number 11611
xLogP3-AA 1.60 (est)
NMR Predictor External link
JECFA Food Flavoring 1056 2-ethoxythiazole
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 15679-19-3 ; 2-ETHOXYTHIAZOLE
Synonyms
  • 2-ethoxy thiazole
  • 2-ethoxy-1,3-thiazole
  • ethyl 2-thiazolyl ether
  • thiazole, 2-ethoxy-
  • 2-thiazolyl ethyl ether
  • 2-ethoxy-1,3-thiazole

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB41282
FooDB:FDB021198
Export Tariff Code:2934.10.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 129.18199157715
Specific gravity @ 25 °C
Pounds per Gallon
Refractive Index 1.5027 to 1.504 @ 20 °C
Boiling Point 157 to 160°C @ 760 mm Hg
Vapor Pressure 2.195 mmHg @ 25 °C
Flash Point TCC Value 53.89 °C TCC
logP (o/w) 1.624 est
Shelf life 12 months (or longer if stored properly.)
Storage notes Refrigerate in tightly sealed containers.
Solubility
alcohol Yes
water, slightly Yes
water, 1745 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Musty
musty, vegetable, roasted, nutty, burnt, phenolic, green, coffee, brothy
General comment At 1.00 % in dipropylene glycol. musty vegetable roasted nut meat burnt phenolic
Mosciano, Gerard P&F 23, No. 3, 55, (1998) At 2.00 %. Musty, vegetative, green, phenolic, nutty, coffee and brothy
Flavor Type: Musty
musty, vegetable, brothy, nutty, coffee, rubbery
Mosciano, Gerard P&F 23, No. 3, 55, (1998) At 2.00 ppm. Musty, vegetative, brothy, nutty and coffee with a slight rubbery nuance

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M,F] 910.90 mg/kg
(Piccirillo et al., 1982b)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for 2-ethoxythiazole usage levels up to:
not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.12 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 6
Click here to view publication 6
average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: -2.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.20000
fruit ices: -0.20000
gelatins / puddings: --
granulated sugar: --
gravies: -0.50000
hard candy: -1.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -0.50000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -0.50000
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61809
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:3
2-ethoxy-1,3-thiazole
Chemidplus:0015679193