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    General Material Information
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methyl laurate

Chemical Structure

General Material Information

Preferred name methyl laurate
Trivial Name Methyl laurate
Short Description methyl dodecanoate
Formula C13 H26 O2
CAS Number 111-82-0
Deleted CAS Number 409108-19-6
FEMA Number 2715
Flavis Number 9.101
ECHA Number 203-911-3
FDA UNII 8IPS6BI6KW
Nikkaji Number J374C
Beilstein Number 1767780
MDL MFCD00008966
COE Number 377
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 180 methyl laurate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 111-82-0 ; METHYL LAURATE
Synonyms
  • dodecanoic acid methyl ester
  • dodecanoic acid, methyl ester
  • lauric acid methyl ester
  • lauric acid, methyl ester
  • metholene 2296
  • methyl dodecanoate
  • methyl dodecylate
  • methyl laurate natural
  • methyl N-dodecanoate
  • methyllaurate
  • stepan C40
  • uniphat A40
  • Methyl laurinate
  • Uniphat A 40
  • Stepan C 40
  • CE 1295
  • Pastell M 12
  • Emery 2296
  • Texaprint SDM 100
  • CE 1290
  • Edenor ME-C 1298-100
  • NSC 5027
  • Agnique ME 1270U
  • Agnique ME 1290
  • Agnique ME 1298
  • Exceparl ML 85
  • Radia 7118
  • Pernil ME-C 1298-100

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Perfumer & Flavorists Start search
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Literature & References

methyl dodecanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:111-82-0
Pubchem (cid):8139
Pubchem (sid):134975354
Flavornet:111-82-0
Pherobase:View
Publications by Info
Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.)
Publications by PubMed
Non-invasive characterization of the adipogenic differentiation of human bone marrow-derived mesenchymal stromal cells by HS-SPME/GC-MS.
Environmentally evaluated HPLC-ELSD method to monitor enzymatic synthesis of a non-ionic surfactant.
Stimulation of nitrogen removal in the rhizosphere of aquatic duckweed by root exudate components.
Electrochemical preparation of polyaniline-polypyrrole solid-phase microextraction coating and its application in the GC determination of several esters.
Electrodeposition of poly(3,4-ethylenedioxythiophene) on a stainless steel wire for solid phase microextraction and GC determination of some esters with high boiling points.
Acid activated montmorillonite as catalysts in methyl esterification reactions of lauric acid.
Diatomite-supported Pd-M (M=Cu, Co, Ni) bimetal nanocatalysts for selective hydrogenation of long-chain aliphatic esters.
Biorefinery approach for coconut oil valorisation: a statistical study.
Crystallization of synthetic haemozoin (beta-haematin) nucleated at the surface of lipid particles.
Spectra and kinetic studies of the compound I derivative of cytochrome P450 119.
Overexpression of the apple alcohol acyltransferase gene alters the profile of volatile blends in transgenic tobacco leaves.
Gas chromatographic/mass spectrometric analysis of the essential oil of Houttuynia cordata Thunb by using on-column methylation with tetramethylammonium acetate.
Enzymatic chemoselective synthesis of secondary-amide surfactant from N-methylethanol amine.
Synthesis of a novel series of 2-methylsulfanyl fatty acids and their toxicity on the human K-562 and U-937 leukemia cell lines.
Purification and characterization of lipase from Rhizopus chinensis cells.
Effect of several factors on the mechanical properties of pressure-sensitive adhesives used in transdermal therapeutic systems.
Preparation of uniform titanium dioxide (TiO2) polystyrene-based composite particles using the glass membrane emulsification process with a subsequent suspension polymerization.
Uniform titanium dioxide (TiO(2)) microcapsules prepared by glass membrane emulsification with subsequent solvent evaporation.
A kinetic study of the synthesis of ascorbate fatty acid esters catalysed by immobilized lipase in organic media.
Production of flavour ketones in aqueous-organic two-phase systems by using free and microencapsulated fungal spores as biocatalysts.
Ultrafiltration of Micellar Solutions Containing Phenols.
Proportion of geometrical hydroperoxide isomers generated by radical oxidation of methyl linoleate in homogeneous solution and in aqueous emulsion.
Solid-phase extraction on C18 silica as a purification strategy in the solution synthesis of a 1-thio-beta-D-galactopyranoside library.
Fatty acid discrimination and omega-hydroxylation by cytochrome P450 4A1 and a cytochrome P4504A1/NADPH-P450 reductase fusion protein.
Determination of Candida tropicalis acyl coenzyme A oxidase isozyme function by sequential gene disruption.
Phycochemical investigations on Centroceras clavulatum (Ceramiales, Rhodophyta).
Phycochemical studies on Scinaia fascicularis (Bonnemaisoniales, Rhodophyta).
Topical application of penetration enhancers to the skin of nude mice: a histopathological study.
Ester synthesis at extraordinarily low temperature of -3 degrees C by modified lipase in benzene.
A GLC method for estimation of chlorophenoxyisobutyric acid in plasma. Pharmacokinetics of a single oral dose of clofibrate in man.
Lipase of Mucor pusillus.
Thermal reactions of methyl linoleate. I. Heating conditions, isolation techniques, biological studies and chemical changes.
Lipid metabolism of rumen ciliates and bacteria. I. Uptake of fatty acids by Isotricha prostoma and Entodinium simplex.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
HMDB (The Human Metabolome Database):HMDB31018
FooDB:FDB003011
Export Tariff Code:2915.90.1050
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
grades: 69%, 74%, 90%, 96%, 99.8%

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 214.34861755371
Specific gravity @ 20 °C
Pounds per Gallon 7.248 to 7.264
Refractive Index 1.431 to 1.433 @ 20 °C
Melting Point 4 to 5°C @ 760 mm Hg
Boiling Point 261 to 262°C @ 760 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 0.011 mmHg @ 25 °C
Flash Point TCC Value 110 °C TCC
logP (o/w) 5.41
Solubility
alcohol Yes
dipropylene glycol Yes
water, 0.8841 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Waxy
waxy, soapy, creamy, coconut, mushroom
Odor strength medium
Substantivity 400 hour(s) at 100.00 %
General comment At 100.00 %. waxy soapy creamy coconut mushroom
Mosciano, Gerard P&F 15, No. 3, 51, (1990) Waxy, soapy, creamy, coconut, with mushroom nuances
Flavor Type: Waxy
waxy, creamy, fatty, soapy, coconut
Mosciano, Gerard P&F 15, No. 3, 51, (1990) At 20.00 ppm. Waxy, creamy, fatty with soapy, coconut nuances

Occurrences

Potential Uses

Applications
Odor purposes Agrumen aldehyde, Aldehydic, Alpine bouquet, Amaryllis, Amber, Ambrette oil replacer, Animal, Apple, Crabapple, Ash mountain ash blossom, Autumn, Azalea, Bark, Bayberry, Beeswax absolute replacer, Berry, Bouquet, Boxwood, Boxwood blossom, Carrot seed, Cassia blossom, Castoreum, Cedar forest, Cedarwood, Cherry blossom, Chypre, Cilantro, Clematis, Clean linen, Clove blossom, Coconut, Cognac, Cortex, Costus, Country meadow, Crabapple blossom, Cream, Cumin oil replacer, Cyclamen, Cypress oil replacer, Daffodil, Daisy, Date, Earth, Elder berry, Elder flower, Fenugreek, Fern, Fig, Fir balsam, Floral, Flouve blossom, Foliage, Fresh outdoors, Fungus, Galangal root, Genet, Ginger white ginger, Gingergrass, Grape, Green leaf, Guaiacwood, Heather, Hollyberry, Incense, Ivy, Leather, Lychee, Maja, Malt, Marjoram, Moss, Musk, New car, Orchid, Orris, Osmanthus, Pansy, Patchouli, Peach, Peach blossom, Pear, Petunia, Pineapple, Plum blossom, Powder, Privet, Privet blossom, Rain, Raisin, Redwood, Reseda, Rose, Rose geranium, Rose tea rose, Rose white rose, Saffron, Seaweed absolute replacer, Soapy sandalwood moss, Stephanotis, Stephanotis, Strawberry, Tobacco, Tonka bean, Tuberose, Tulip, Vetiver, Wine, Wintergreen
Flavoring purposes Brandy, Bread, Burnt, Caramel, Carrot seed, Cheese, Cilantro, Custard, Dairy, Fenugreek, Galangal root, Guaiacwood, Lettuce, Marjoram, Milk malted milk, Pork, Whiskey
Other purposes Clean, Fixer, Fruit dried fruit, Hair, Liverwort, Petal waxy petal, Vine, Waxy, Wool fat
Cosmetic purposes Perfuming agents, Skin conditioning, Skin conditioning - emollient

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LDLo 48 mg/kg
Journal of the Reticuloendothelial Society. Vol. 3, Pg. 250, 1966.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for methyl laurate usage levels up to:
4.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 5.10 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): 0.500005.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.500005.00000
fruit ices: 0.500005.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 0.020005.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 2, Revision 1 (FGE.02) : Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):111-82-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8139
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
methyl dodecanoate
Chemidplus:0000111820
RTECS:OF0670000 for cas# 111-82-0