amber dodecane

Amber dodecane, scientifically known as 1-methoxy-1-methylcyclododecane, is an organic compound classified as a cyclododecane ether with the molecular formula C14H28O. It appears as a clear, colorless liquid with a distinctive woody and ambergris-like aroma. Key synonyms include madrox (a commercial name from Givaudan), methyl 1-methylcyclododecyl ether, and 1-methyl-1-methoxycyclododecane. This compound is mainly sourced through synthetic organic chemical processes, typically involving cyclododecane derivatives. For structured chemical information, see the PubChem record. Amber dodecane finds primary use in the fragrance industry due to its unique olfactory profile, enhancing woody and amber accord compositions.

Amber dodecane is primarily utilized as a fragrance agent in perfumes where it contributes woody, ambergris, and tobacco-like notes. Biologically, it does not occur naturally but is synthetically derived. Its strong substantivity, lasting approximately 28 hours at full concentration, makes it valuable in fougère and chypre type fragrance constructions. According to FEMA (US), its usage is recommended mainly in perfuming agents. Its olfactory character blends well with labdanum, musk, moss, and fern accords, strengthening the fragrance body and harmonizing top notes.

Amber dodecane exhibits a molecular weight of approximately 212.38 g/mol and has a specific gravity of 0.921 at 25°C. It boils between 248 and 249°C under standard atmospheric pressure, indicating moderate volatility. The compound shows a high estimated octanol-water partition coefficient (logP ~5.5), consistent with lipophilic substances, influencing its solubility and distribution in formulations. It dissolves readily in alcohol and has limited water solubility (~0.48 mg/L at 25°C). Stability assessments reveal good chemical resilience in alcoholic solutions, soaps, and powder detergents, with moderate stability in antiperspirant sprays and varying pH environments. It exhibits poor stability in liquid bleach. The flash point is about 212°F (100°C), relevant for handling and formulation safety.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
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Safety information

European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg Food and Chemical Toxicology. Vol. 30, Pg. 81S, 1992.
Dermal Toxicity:
skin-rabbit LDLo 5000 mg/kg Food and Chemical Toxicology. Vol. 30, Pg. 81S, 1992.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for amber dodecane usage levels up to:
	10.0000 % in the fragrance concentrate.
Recommendation for amber dodecane flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):37514-30-0

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :161949

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

1-methoxy-1-methylcyclododecane

Chemidplus:0037514300