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2-hydroxybenzaldehyde
General Material Information
| Preferred name | 2-hydroxybenzaldehyde |
| Trivial Name | Salicylaldehyde |
| Short Description | o-hydroxybenzaldehyde |
| Formula | C7 H6 O2 |
| CAS Number | 90-02-8 |
| FEMA Number | 3004 |
| Flavis Number | 5.055 |
| ECHA Number | 201-961-0 |
| FDA UNII | 17K64GZH20 |
| Nikkaji Number | J10.607K |
| Beilstein Number | 0471388 |
| MDL | MFCD00003317 |
| COE Number | 605 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 897 salicylaldehyde |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 90-02-8 ; SALICYLALDEHYDE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| 2-hydroxybenzaldehyde | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 90-02-8 |
| Pubchem (cid): | 6998 |
| Pubchem (sid): | 134970618 |
| Pherobase: | View |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C06202 |
| HMDB (The Human Metabolome Database): | HMDB34170 |
| FooDB: | FDB012456 |
| Export Tariff Code: | 2912.49.2600 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 122.12322235107 |
| Specific gravity | @ 20 °C |
| Pounds per Gallon | 9.689 to 9.73 |
| Refractive Index | 1.571 to 1.574 @ 20 °C |
| Melting Point | 1 to 2°C @ 760 mm Hg |
| Boiling Point | 196 to 197°C @ 760 mm Hg |
| Boiling Point | 96 to 97°C @ 30 mm Hg |
| Acid Value | 10 max KOH/g |
| Vapor Pressure | 0.329 mmHg @ 25 °C |
| Vapor Density | 4.2 |
| Flash Point TCC Value | 76.67 °C TCC |
| logP (o/w) | 1.81 |
| Solubility | |
| alcohol | Yes |
| water, 17000 mg/L @ 86C (exp) | Yes |
| water | No |
Organoleptic Properties
| Odor Type: Medicinal | |
| medicinal, spicy, cinnamon, wintergreen, cooling | |
| General comment | At 10.00 % in dipropylene glycol. medical spicy cinnamon wintergreen cooling |
| Mosciano, Gerard P&F 16, No. 2, 49, (1991) | Medicinal, spicy cinnamon-wintergreen like cooling note |
| Flavor Type: Spicy | |
| spicy, medicinal, astringent | |
| Mosciano, Gerard P&F 16, No. 2, 49, (1991) | At 20.00 ppm. Spicy, medicinal and astringent |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Cassia, Cinnamon, Coffee, Grape, Meadowsweet, Seaweed absolute replacer, Spice, Tobacco, Vanilla, Violet, Wallflower |
| Flavoring purposes | Tea, Tomato |
| Other purposes | Spirea |
| Cosmetic purposes | Perfuming agents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 21/22 - Harmful in contact with skin and if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Human Experience: | |
| 2 % solution: no irritation or sensitization. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 520 mg/kg (Moreno, 1977af) gavage-mouse LD50 [sex: M] 504 mg/kg (Eastman Kodak Co., 1991b) intraperitoneal-mouse LD50 231 mg/kg Chemotherapy Vol. 16, Pg. 371, 1971. gavage-rat LD50 [sex: M] 566 mg/kg (Eastman Kodak Co., 1991b) oral-mouse LD50 504 mg/kg National Technical Information Service. Vol. OTS0533438 oral-rat LD50 520 mg/kg Food and Cosmetics Toxicology. Vol. 17, Pg. 903, 1979. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 3000 mg/kg Food and Cosmetics Toxicology. Vol. 17, Pg. 903, 1979. skin-guinea pig LD50 20 ml/kg National Technical Information Service. Vol. OTS0533438 skin-rat LD50 600 mg/kg Food and Cosmetics Toxicology. Vol. 17, Pg. 903, 1979. subcutaneous-rat LD50 900 mg/kg Food and Cosmetics Toxicology. Vol. 17, Pg. 903, 1979. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for 2-hydroxybenzaldehyde usage levels up to: | |||
| 1.0000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 84.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 16.00 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 6.30000 | |
| beverages(nonalcoholic): | - | 0.55000 | |
| beverages(alcoholic): | - | 5.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 11.00000 | 18.00000 | |
| condiments / relishes: | - | 2.00000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 1.10000 | |
| fruit ices: | - | 1.10000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 1.80000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):90-02-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6998 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 2-hydroxybenzaldehyde |
| Chemidplus:0000090028 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:VN5250000 for cas# 90-02-8 |