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butylated hydroxytoluene

Chemical Structure

General Material Information

Preferred name butylated hydroxytoluene
Trivial Name 2,6-Di-tert-butyl-4-methylphenol
Short Description BHT
Formula C15 H24 O
CAS Number 128-37-0
Deleted CAS Number 102962-45-8
FEMA Number 2184
ECHA Number 204-881-4
FDA UNII 1P9D0Z171K
Nikkaji Number J2.939D
Beilstein Number 1911640
MDL MFCD00011644
xLogP3-AA 5.30 (est)
Bio Activity Summary External link
NMR Predictor External link
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 128-37-0 ; BUTYLATED HYDROXYTOLUENE
Synonyms
  • advastab 401
  • agidol
  • alkofen BP
  • annulex BHT
  • antioxidant 264
  • antioxidant 29
  • antioxidant 30
  • antioxidant 4
  • antioxidant DBPC
  • antioxidant KB
  • antioxidant MPJ
  • antioxidant T 501
  • antox QT
  • antracine 8
  • antrancine 8
  • B.H.T.
  • BHT
  • BHT (butylated hydroxy toluene) tech grade
  • BHT FCC/NF
  • 2,6-bis(tert- butyl)-4-methylphenol
  • catalin antioxydant 1
  • catalin CAO-3
  • chemanox 11
  • (2,5-cyclohexadiene-1,4-diylidene)-dimalononitrile
  • dalpac
  • deenax
  • 2,6-di-(tert-butyl)-4-methylphenol
  • 2,6-di-t-butyl-4-methylphenol
  • 2,6-di-t-butyl-p-cresol
  • 2,6-di-tert-butyl-1-hydroxy-4-methylbenzene
  • 2,6-di-tert-butyl-4-cresol
  • 2,6-di-tert-butyl-4-hydroxytoluene
  • 2,6-di-tert-butyl-4-methyl phenol
  • 2,6-di-tert-butyl-4-methylhydroxybenzene
  • 2,6-di-tert-butyl-4-methylphenol
  • 2,6-di-tert-butyl-p-cresol
  • 2,6-di-tert-butyl-p-methylphenol
  • 2,6-di-tert-butyl-para-cresol
  • 2,6-di-tert-butylcresol
  • 2,6-bis(1,1-dimethylethyl)-4-methylphenol
  • embanox BHT
  • hydagen DEO
  • butylated hydroxy toluene
  • butylated hydroxy toluene (BHT) N.F. grade powder (40 mesh)
  • 4-hydroxy-3,5-di-tert-butyltoluene
  • 1-hydroxy-4-methyl-2,6-di-tert-butylbenzene
  • butylated hydroxytoluene (BHT) N.F. grade powder (60 mesh)
  • butylated hydroxytoluene (BHT) FCC grade
  • butylated hydroxytoluene (BHT) N.F. grade
  • butylated hydroxytoluene (BHT) NF & EP grade
  • butylated hydroxytoluene NF & EP grade powder (325 mesh)
  • butylated hydroxytoluene NF & EP grade powder (60 mesh)
  • butylated hydroxytoluene NF & EP grade powder (80 mesh)
  • impruvol
  • ional
  • kerabit
  • 4-methyl-2,6-di-t-butyl-phenol
  • 4-methyl-2,6-ditertbutylphenol
  • 4-methyl-2,6-tert-butylphenol
  • nocrac 200
  • nonox TBC
  • parabar
  • paranox 441
  • tenox BHT food-grade antioxidant
  • vianol
  • 2,6-ditert-butyl-4-methylphenol
  • Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
  • p-Cresol, 2,6-di-tert-butyl-
  • 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
  • CAO 1
  • CAO 3
  • DBPC
  • 2,6-Di-tert-butyl-p-methylphenol
  • 4-Hydroxy-3,5-di-tert-butyltoluene
  • Ionol
  • Ionole
  • 4-Methyl-2,6-di-tert-butylphenol
  • Parabar 441
  • Sustane BHT
  • Tenamene 3
  • Topanol OC
  • Topanol O
  • Topanol
  • Dibunol
  • AO 4K
  • Dibutylated hydroxytoluene
  • Ionol 1
  • Buks
  • 2,6-Di-tert-butylcresol
  • Stavox
  • Di-tert-Butyl-4-methylphenol
  • o-Di-tert-butyl-p-methylphenol
  • Di-tert-butyl-p-cresol
  • 2,6-Di-tert-butyl-p-cresol
  • Antioxidant 4K
  • Sumilizer BHT
  • Di-tert-butylcresol
  • Catalin CAO 3
  • Vanlube PCX
  • Vanlube PC
  • 2,6-Di-tert-butyl-p-cresole
  • AO 29
  • P 21
  • Agidol 1
  • AO 4
  • Vulkanox KB
  • 2,6-Di-tert-butylmethylphenol
  • 2,6-Di-tert-butyl-4-hydroxytoluene
  • 2,6-Di-tert-butyl-4-methyl-1-hydroxybenzene
  • Ionol BHT
  • AOX 4
  • AOX 4K
  • Tenox BHT
  • Topanol BHT
  • Swanox BHT
  • 2,6-Di-tert-butyl-4-methylhydroxybenzene
  • Vanox PC
  • Antage BHT
  • 3,5-Di-tert-butyl-4-hydroxytoluene
  • Popol
  • Ralox BHT
  • Permanax BHT
  • Topanol OL
  • Naugard BHT
  • BAT
  • Ultranox 226
  • Lubrizol 817
  • 2,6-Di-tert-butyl-4-methylphenol
  • P 21 (phenol)
  • T 501
  • Ionol 330
  • Yoshinox BHT
  • 2,6-Bis(tert-butyl)-4-methylphenol
  • 2,6-tert-Butyl-4-methylphenol
  • Ionol K
  • Ionol CP
  • 4-Methyl-2,6-bis(1,1-dimethylethyl)phenol
  • T 501 (phenol)
  • BHT 264
  • Lowinox BHT
  • Selosol H 633
  • Tonarol
  • BHT-C
  • E 321
  • Dibutylcresol
  • Dibutylhydroxytoluene
  • NSC 6347
  • Nocrac 2000
  • 2,6-Di-tert-butyl-4-cresol
  • Topanol O-FG
  • Sumilizer BHT-R
  • BHT Swanox
  • Agidol 1A
  • 2,6-Di(tert-butyl)hydroxytoluene
  • B-NOX BHT-P
  • Nipanox
  • K-NOX-BHT
  • 3,5-Di-tert-butyl-p-hydroxytoluene
  • Grindox BHT
  • 4-Methyl-2,6-ditertbutyl phenol
  • FG
  • Addiox 1005
  • 2,6-Di-t-butyl-4-methylphenol
  • 2,6-Ditertbutyl paracresol
  • Topanol C
  • Vulkanox BHT
  • Na-Lube AO 220
  • Dibutyl paracresol
  • Additin RC 1220
  • PN 01
  • M 4801
  • Antioxidant 501
  • BHT 501
  • Lavinix BHT
  • Nipanox BHT
  • H-BHT
  • Antioxidant OC
  • 3,5-Bis(1,1-dimethylethyl)-4-hydroxytoluene
  • Antioxidant BHT
  • T 502A
  • NK-BHT
  • 2,6-Di-tert-butyl-4-methyl phenol
  • Nocrac SP-N
  • AO 246
  • Chinox BHT
  • Antioxidant 502A
  • K-NOX BHT-P
  • Antiager 264
  • Antioxidant 1005
  • DW 3432 (phenol)
  • DW 3432
  • ST-4-1

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

2,6-ditert-butyl-4-methylphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:128-37-0
Pubchem (cid):31404
Pubchem (sid):134974578
Pherobase:View
Publications by Info
EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
Publications by PubMed
Effect of peanut skin extract on chemical stability and sensory properties of salami during storage.
Identification of tartary buckwheat tea aroma compounds with gas chromatography-mass spectrometry.
Utilization of adzuki bean extract as a natural antioxidant in cured and uncured cooked pork sausages.
Oxidative stability of cooked, frozen, reheated beef patties: effect of antioxidants.
Effects of sodium lactate and acetic acid derivatives on the quality and sensory characteristics of hot-boned pork sausage patties.
Sensory evaluation and consumer acceptance of eggs from hens fed flax seed and 2 different antioxidants.
Antioxidants in bakery products: a review.
Antioxidant properties of dried plum ingredients in raw and precooked pork sausage.
Flavor authentication studies of alpha-ionone, beta-ionone, and alpha-ionol from various sources.
Bioconversion of lutein using a microbial mixture--maximizing the production of tobacco aroma compounds by manipulation of culture medium.
Effect of enrobing and antioxidants on quality characteristics of precooked pork patties under chilled and frozen storage conditions.
Effects of olive, canola, and sunflower oils on the formation of volatiles from the Maillard reaction of lysine with xylose and glucose.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C14693
HMDB (The Human Metabolome Database):HMDB33826
FooDB:FDB011992
Export Tariff Code:2907.19.1000
FDA Listing of Food Additive Status:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•the antioxidant formulations most commonly used in edible products contain various combinations of bha, bht, &or propyl gallate together with citric acid in a suitable solvent. •grades: technical; feed; "food chemical codex" •inol cp shell •embanox 2 rhone-poulenc •hydagen deo henkel

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 220.35548400879
Melting Point 70 to 73°C @ 760 mm Hg
Vapor Pressure 15 mmHg @ 141 °C
Vapor Density 7.6
Flash Point TCC Value 93.33 °C TCC
logP (o/w) 5.1
Solubility
alcohol Yes
water, 0.6 mg/L @ 25 °C (exp) Yes

Organoleptic Properties

Odor Type: Phenolic
phenolic, camphoreous
Odor strength low
Substantivity 400 hour(s) at 20.00 % in dipropylene glycol
General comment At 100.00 %. mild phenolic camphor

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 07 - Keep container tightly closed.
S 22 - Do not breath dust.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Chronic aquatic toxicity (Category 1), H410
GHS Label elements, including precautionary statements
Pictogramenvironment.jpg
Signal word Warning
Hazard statement(s)
H410 - Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
P273 - Avoid release to the environment.
P391 - Collect spillage. Hazardous to the aquatic environment
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
oral-rat LD50 890 mg/kg
Neoplasma. Vol. 24, Pg. 253, 1977.

intravenous-mouse LD50 180 mg/kg
BEHAVIORAL: SLEEP
Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

intraperitoneal-mouse LD50 138 mg/kg
Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

oral-mouse LD50 650 mg/kg
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

oral-guinea pig LD50 10700 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.

oral-cat LDLo 940 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.

intraperitoneal-mouse LD50 138 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: HEMORRHAGE LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Toxicology and Applied Pharmacology. Vol. 61, Pg. 475, 1981.

oral-rabbit LDLo 2100 mg/kg
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
antioxidants and preservatives for fragrance and flavor
Recommendation for butylated hydroxytoluene usage levels up to:
not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):128-37-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31404
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3077
WGK Germany:1
2,6-ditert-butyl-4-methylphenol
Chemidplus:0000128370
EPA/NOAA CAMEO:hazardous materials
RTECS:128-37-0