1-(2-isopropyl-5-methyl cyclohexyl)-5-oxopyrrolidine-3-carboxylic acid isobutyl amide

1-(2-isopropyl-5-methyl cyclohexyl)-5-oxopyrrolidine-3-carboxylic acid isobutyl amide is a complex organic compound characterized by a cyclohexyl ring substituted with isopropyl and methyl groups attached to an oxopyrrolidine carboxylic acid isobutyl amide moiety. It is recognized primarily as a flavor compound exhibiting mild cooling sensations when dissolved at low concentrations, such as 10 ppm in water. Its chemical structure includes amide and ketone functionalities, contributing to its sensory profile. This compound is listed under various synonymous names highlighting subtle differences in spelling typically found in chemical literature. It is not currently employed widely in commercial fragrances or flavor products but is of academic interest for sensory modulation. For authoritative chemical referencing, a controlled vocabulary link is available on PubChem. The molecule may be derived via chemical synthesis focused on cyclic amide derivatives with specific substitutions, emphasizing its specificity and niche application potential.

This compound does not have a noted natural biological occurrence and is primarily produced synthetically for investigational purposes. Its mild cooling flavor property at dilute aqueous concentrations suggests potential utility as a sensory modifier in functional flavor research, although it is not authorized or recommended for use in commercial fragrances or flavors. Regulatory frameworks, including FEMA (US), do not approve it for typical flavor or fragrance applications, and it remains classified within information-only categories in safety guidelines. Its structural features align it with other cooling agents used in food science and personal care product development, though formal adoption is pending thorough toxicological evaluation. Continued research may explore broader applicability in controlled experimental environments.

The compound’s physicochemical characteristics are shaped by its cyclohexyl ring and amide functionality, providing moderate polarity and solubility behavior in aqueous systems. The presence of isopropyl and methyl substituents introduces steric effects influencing molecular interactions and volatility. Its chemical stability and inert nature regarding hazardous classifications enable it to be handled safely in technical scenarios. The mild cooling sensation observed at low concentrations indicates interaction with sensory receptors modulated by molecular shape and hydrophobicity. These properties affect formulation strategies, especially when integrating cooling sensations without overpowering flavor profiles. The compound’s moderate molecular weight and functional groups may impact partitioning between phases in complex matrices, which is relevant for solution stability and sensory efficacy.

None found

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
information only not used for fragrances or flavors
Recommendation for 1-(2-isopropyl-5-methyl cyclohexyl)-5-oxopyrrolidine-3-carboxylic acid isobutyl amide usage levels up to:
	not for fragrance use.
Recommendation for 1-(2-isopropyl-5-methyl cyclohexyl)-5-oxopyrrolidine-3-carboxylic acid isobutyl amide flavor usage levels up to:
	not for flavor use.

Safety references

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