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dextro,laevo-isoleucine
General Material Information
| Preferred name | dextro,laevo-isoleucine |
| Trivial Name | DL-Isoleucine |
| Short Description | 2-amino-3-methylpentanoic acid |
| Formula | C6 H13 N O2 |
| CAS Number | 443-79-8 |
| Deleted CAS Number | 1160211-67-5 |
| FEMA Number | 3295 |
| Flavis Number | 17.01 |
| ECHA Number | 207-139-8 |
| FDA UNII | 5HX0BYT4E3 |
| Nikkaji Number | J1.283A |
| Beilstein Number | 1721790 |
| MDL | MFCD00004268 |
| COE Number | 10127 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 1422 DL-isoleucine |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 443-79-8 ; DL-ISOLEUCINE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| 2-amino-3-methylpentanoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 443-79-8 |
| Pubchem (cid): | 791 |
| Pubchem (sid): | 135017572 |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | C16434 |
| HMDB (The Human Metabolome Database): | HMDB33923 |
| FooDB: | FDB012123 |
| Export Tariff Code: | 2922.49.4050 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Suppliers
| BOC Sciences | Glentham Life Sciences |
| Penta International | Santa Cruz Biotechnology |
| Sigma-Aldrich | TCI AMERICA |
| Penta International Corporation |
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 131.17500305176 |
| Melting Point | 290 to 292°C @ 760 mm Hg |
| Boiling Point | 225 to 226°C @ 760 mm Hg |
| Vapor Pressure | 0.031 mmHg @ 25 °C |
| Flash Point TCC Value | 110 °C TCC |
| logP (o/w) | 0.799 est |
| Solubility | |
| water, 2.191e+004 mg/L @ 25 °C (est) | Yes |
| water, 2.23E+04 mg/L @ 25 °C (exp) | Yes |
| alcohol | No |
Organoleptic Properties
| Odor Type: Odorless | |
| Odor strength | none |
| General comment | At 100.00 %. odorless |
| Flavor Type: Bitter | |
| bitter | |
| General comment | Bitter |
Potential Uses
| Applications | |
| Other purposes | Antistatic agents , Hair conditioning , Skin conditioning |
| Cosmetic purposes | Antistatic agents , Hair conditioning , Skin conditioning |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| None - None found. | |
| S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| special dietary and nutritional additives | |||
| Recommendation for dextro,laevo-isoleucine usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 5.20 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 5 | |||
| Click here to view publication 5 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 50.00000 | |
| beverages(nonalcoholic): | - | 50.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | 50.00000 | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | 50.00000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | 50.00000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | 50.00000 | |
| milk products: | - | 50.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | 50.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Amino acids from chemical group 34 Flavouring Group Evaluation 26, Revision 1 - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 79, (FGE.79)[1] - Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008) View page or View pdf |
| Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):443-79-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :791 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| 2-amino-3-methylpentanoic acid |
| Chemidplus:0000443798 |