bergoxane

Bergoxane, known chemically as trimethyl hexahydrospiro-1,3-dioxane-5,2-(1H)-naphthalene, is a synthetic organic compound. It has several synonyms including dimethyl hexahydronaphthyl dihydroxymethyl acetal and spiro[1,3-dioxane-5,2'(2H)-napthalene], hexahydro-2,5'5'-trimethyl-. The compound exhibits a medium-strength green odor with woody, herbal, and vetiver-like notes, making it valuable in fragrance applications. Bergoxane’s molecular structure includes a spiro-dioxane ring fused to a hexahydronaphthalene backbone, enhancing its stability. It is categorized in PubChem, supporting standardized chemical identification and data integration. Bergoxane is generally produced via chemical synthesis, and its odor qualities are best perceived in diluted solutions such as 10% in dipropylene glycol.

Bergoxane does not occur naturally but is used primarily in the fragrance industry as a green, woody, and herbal aromatic agent. It contributes characteristic leaf-like and weedy nuances suitable for floral and vetiver accords. Cosmetic applications include its use in perfumes and tonics for imparting fresh and natural odor profiles. Regulatory assessments such as IFRA (Global) provide usage limits, recommending bergoxane concentrations up to 5% in fragrance concentrates. The compound is not recommended for flavor use. Its stability in neutral and alkaline media supports its incorporation into a variety of product formulations without compromising olfactory integrity.

Bergoxane exhibits a specific gravity of approximately 1.02 at 20 °C, indicating a density slightly higher than water. It has a relatively high flash point near 93 °C (200 °F), reflecting low volatility under typical handling conditions. The compound dissolves readily in alcohol but is insoluble in water, influencing its formulation flexibility particularly in alcoholic or oil-based systems. Its chemical structure ensures stability of odor and color in neutral and alkaline environments, making it resilient in various product matrices. These properties facilitate its use as a persistent aroma ingredient with substantivity extending to 400 hours at 100% concentration. Such characteristics make bergoxane suitable for long-lasting fragrance effects.

HMDB (The Human Metabolome Database):

Search

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for bergoxane usage levels up to:
	5.0000 % in the fragrance concentrate.
Recommendation for bergoxane flavor usage levels up to:
	not for flavor use.

Safety references

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data