1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one

1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one is a chemical compound noted for slight cooling and bitter drying effects in aqueous solutions at 40 ppm.

General Material Description

1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one is an organic chemical compound with a complex structure comprising a cyclohexyl group substituted with isopropyl and methyl groups, linked to a piperidin-2-one framework bearing a pyrrolidine-1-carbonyl substituent. It is recognized for its distinct sensory attribute of slight cooling accompanied by a bitter and drying sensation when diluted to approximately 40 ppm in water. Alternative names include 1-(2-iso propyl-5-methyl-cyclohexyl)-5-(pyrrolidine-1-carbonyl)-piperidin-2-one and variants thereof. For further validated chemical information, it is indexed in the PubChem database. This compound is synthetically derived and is not sourced from natural extracts, reflecting its specialized application profile.

Occurrence, Applicability & Potential Uses

This compound has no known natural biological occurrence and is synthesised for research rather than commercial applications. It is categorized for informational use only and is explicitly not employed within fragrance or flavor formulations. Its sensory profile, marked by slight cooling and a drying bitterness, may suggest potential investigational interest in cooling agents or sensory modifiers, but no recognized standards such as IFRA (Global) or FEMA (US) endorse its use in perfumery or flavoring. This specialized status limits its practical application mainly to chemical and sensory research contexts.

Physico-Chemical Properties Summary

The molecule features a combination of hydrophobic cyclohexyl and piperidinone moieties, contributing to limited aqueous solubility and moderate chemical stability. Its structural elements suggest low volatility and a molecular weight conducive to slow diffusion in formulations. The presence of a pyrrolidine-1-carbonyl group could influence hydrogen bonding and intermolecular interactions, affecting sensory perception such as the noted cooling effect and bitterness when dissolved in water. Specific thermal and spectral data are not available, but the compound’s profile indicates it is suitable for detailed sensory characterization rather than broad formulation use.

FAQ

What is 1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one?

1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one is a synthetic organic compound characterized by a cyclohexyl ring substituted with isopropyl and methyl groups linked to a piperidin-2-one ring with a pyrrolidine-1-carbonyl group. It is noted for producing a slight cooling sensation alongside a bitter, drying effect at low concentrations in water. The compound is primarily of academic interest and is cataloged in chemical databases such as PubChem for reference.

Where is this compound used and how is it applied?

Currently, 1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one is not used in fragrance or flavor applications. Its sensory properties have been characterized in aqueous solution, but it remains restricted to informational and research contexts. The compound’s cooling and bitter drying effects might make it a candidate for scientific studies in sensory modulation, although no commercial use in consumer products has been established. This limited scope is reflected in safety guidelines indicating no recommended usage levels for fragrances or flavors.

What safety and regulatory information is available for this compound?

Safety data for 1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one indicate no classified hazards according to OSHA's 29 CFR 1910 standards (US). No specific hazard or precautionary statements have been identified, and toxicity parameters including oral, dermal, and inhalation effects remain undetermined. Regulatory frameworks such as IFRA or FEMA do not presently acknowledge this compound for use in fragrances or flavors. Therefore, it is recommended solely for informational purposes with no established safe exposure levels in consumer products.

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

None found

Publications by US Patents
8,575,349 - Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds

Other Information

General Material Information

Trivial Name	1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one
Synonyms	1-(2-iso propyl-5-methyl-cyclohexyl)-5-(pyrrolidine-1-carbonyl)-piperidin-2-one 1-(2-iso propyl-5-methylcyclohexyl)-5-(pyrrolidine-1-carbonyl)piperidin-2-one

PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Flavor Type: Cooling
cooling, bitter, dry
General comment	At 40.00 ppm in water. slight cooling, and bitter and drying effect

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
information only not used for fragrances or flavors
Recommendation for 1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one usage levels up to:
	not for fragrance use.

Recommendation for 1-(2-isopropyl-5-methyl cyclohexyl)-5-(pyrrolidine-1-carbonyl) piperidin-2-one flavor usage levels up to:
	not for flavor use.

Safety references

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