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2-ethyl-3-methoxypyrazine

Chemical Structure

General Material Information

Preferred name 2-ethyl-3-methoxypyrazine
Trivial Name 2-Ethyl-3-methoxypyrazine
Short Description pyrazine, 2-methoxy-3-ethyl
Formula C7 H10 N2 O
CAS Number 25680-58-4
Flavis Number 14.112
ECHA Number 247-184-0
FDA UNII ZBM5LD0WE9
Nikkaji Number J208.493G
MDL MFCD00006129
COE Number 11329
NMR Predictor External link
Synonyms
  • earthy pyrazine
  • 2-ethyl-3-methoxy pyrazine
  • 2-ethyl-3-methoxy-pyrazine
  • 2 methoxy 3 ethyl pyrazine
  • 2-methoxy-3-ethyl pyrazine
  • 2-methoxy-3-ethylpyrazine
  • pyrazine, 2-ethyl-3-methoxy-
  • pyrazine, 2-methoxy-3-ethyl
  • 2-Methoxy-3-ethylpyrazine
  • 3-Ethyl-2-methoxypyrazine

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB40054
FooDB:FDB019741
Export Tariff Code:2933.99.8090
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 138.16990661621
Specific gravity @ 25 °C
Pounds per Gallon
Boiling Point 80 to 95°C @ 10 mm Hg
Vapor Pressure 1.577 mmHg @ 25 °C
Flash Point TCC Value 68.89 °C TCC
logP (o/w) 1.8
Solubility
alcohol Yes
water, 2474 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Earthy
potato raw potato, earthy, green, pepper bell pepper, nutty
General comment At 0.10 % in dipropylene glycol. raw potato earthy bell pepper nutty
As with all pyrazines this is used in tiny traces – Earthy Pyrazine at 0.1% in IPM smells rather like raw potato or freshly dug soil, but this material is also present in the scent of coffee and chocolate so it’s more versatile than might at first be thought. Even at this dilution this is a very strong scent that combines well with Geosmin, Terranol and similar materials to give a wet effect. Also with nutty, chocolatey and, perhaps surprisingly with green notes, to give warmth, depth and diffusion. Raw-potato, damp-soil, musty, natural, nutty, roasted

Occurrences

Potential Uses

Applications
Odor purposes Coffee, Earth
Flavoring purposes Nut, Pepper bell pepper, Potato

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 37/38 - Irritating to respiratory system and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 39 - Wear eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 2-ethyl-3-methoxypyrazine usage levels up to:
0.0200 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.17 (μg/capita/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf

Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):25680-58-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :33135
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-ethyl-3-methoxypyrazine
Chemidplus:0025680584