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methyl acetate

Methyl acetate is an ester with a fruity, ethereal odor used as a flavoring agent, fragrance solvent, and industrial chemical with the formula C3H6O2.
Chemical Structure

General Material Description

Methyl acetate is a colorless volatile ester with the molecular formula C3H6O2 and the IUPAC name methyl ethanoate. It appears as a clear liquid and emits a distinctive ethereal, fruity odor reminiscent of solvents and fresh fruits. This compound is widely recognized under synonyms including acetic acid methyl ester and methyl acetic ester. Methyl acetate is naturally present in various fruits such as apples, bananas, and berries, contributing to their aroma profiles. Industrially, it is typically manufactured through the esterification of acetic acid with methanol. The compound is well documented in chemical databases such as ChEBI and is sourced both naturally and synthetically for applications in flavors and fragrances.

Occurrence, Applicability & Potential Uses

Methyl acetate occurs naturally in a broad range of fruits including apples, bananas, raspberries, strawberries, as well as in fermented products like beer and brandies. It is found in some cheeses and plants such as ginger and water mint, reflecting its wide biological distribution. In industrial and commercial contexts, it serves as a flavor enhancer and fragrance agent, mimicking notes associated with fruits such as currant and passion fruit while also replacing ginger root oil in perfumery. The compound is utilized as a solvent in cosmetics and cleaning agents. Regulatory evaluation under FEMA (US) provides guidance on safe use concentrations in flavor applications, emphasizing controlled usage to leverage its sensory and solvent properties effectively.

Physico-Chemical Properties Summary

Methyl acetate exhibits a low molecular weight of approximately 74 g/mol and a modest logP of 0.18, reflecting balanced polarity with moderate solubility in water and alcohols. It has a low flash point near 15 °C (TCC), indicating high flammability requiring careful handling. The boiling point ranges from 56 to 58 °C under standard pressure, facilitating volatility desirable in fragrance evaporation. Its specific gravity varies between 0.932 and 0.942 at 25 °C, with a refractive index in the range of 1.355 to 1.365 at 20 °C. Vapor pressure is relatively high at 368 mmHg at room temperature, reinforcing its volatility and vapor presence in formulations. These properties support its efficacy as a solvent and aroma carrier but necessitate adequate ventilation and safety precautions during use.

FAQ

What is methyl acetate and what are its main characteristics?
Methyl acetate is an organic ester with the chemical formula C3H6O2, commonly known as acetic acid methyl ester. It is a colorless liquid characterized by a fruity, ethereal odor. The compound occurs naturally in various fruits and fermented products and is widely used as a flavoring and fragrance agent. It is also employed as a solvent in cosmetics and industrial applications due to its volatility and moderate polarity.
Where does methyl acetate occur naturally and how is it used in industry?
Methyl acetate is naturally present in fruits such as apples, bananas, blackberries, raspberries, and strawberries, as well as in beverages like beer and brandies. It also occurs in plants such as ginger and water mint. Industrially, it is synthesized for use as a flavor enhancer, fragrance component, and solvent. The compound contributes fruity and ethereal notes to flavor and fragrance formulations and serves as a substitute for ginger root oil in perfumery.
What regulations and safety considerations apply to methyl acetate usage?
Methyl acetate is regulated for use in flavors and fragrances under standards such as FEMA (US) which specify safe usage concentrations. It is classified as highly flammable with an irritant hazard, requiring adherence to safety measures including avoiding ignition sources and proper handling to prevent skin and eye irritation. Safety data sheets provide guidelines on toxicity and exposure limits, and organizations like IFRA (Global) offer codes of practice for fragrance use. Consumers and formulators should consult regulatory sources and assess safety information prior to use.

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Literature & References

methyl acetate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:79-20-9
Pubchem (cid):6584
Pubchem (sid):134971255
Pherobase:View
Publications by PubMed
A shock tube laser schlieren study of methyl acetate dissociation in the fall-off regime.
Surface treatment with methyl formate-methyl acetate increased the shear bond strength between reline resins and denture base resin.
(4'-Acet-yloxy-1,3,1'-trioxo-1,3,4,4a,4b,5,6,7,9,9a-deca-hydro-spiro-[indene-2,9'-pyrano[4,3-a]pyrrolizin]-3'-yl)methyl acetate.
High stability silver nanoparticles-graphene/poly(ionic liquid)-based chemoresistive sensors for volatile organic compounds' detection.
Microfluidic production of single micrometer-sized hydrogel beads utilizing droplet dissolution in a polar solvent.
Measuring real-time concentration trends of individual VOC in an elementary school using a sub-ppb detection μGC and a single GC-MS analysis.
Refined OPLS all-atom force field parameters for n-pentadecane, methyl acetate, and dimethyl phosphate.
Impact of activation methods on persulfate oxidation of methyl tert-butyl ether.
Comparative volatile profiles in soy sauce according to inoculated microorganisms.
Determination of E,E-farnesol in Makgeolli (rice wine) using dynamic headspace sampling and stir bar sorptive extraction coupled with gas chromatography-mass spectrometry.
Chemical constituents from the rice fermented with the edible mushroom Pleurotus eryngii and their quinone oxidoreductase 1 inducing effect.
Local conformation and intermolecular interaction of rigid ring polymers are not always the same as the linear analogue: cyclic amylose tris(phenylcarbamate) in Θ solvents.
Phytogenic biosynthesis and emission of methyl acetate.
A polarizable force field of dipalmitoylphosphatidylcholine based on the classical Drude model for molecular dynamics simulations of lipids.
Quantitative analysis of fragrance and odorants released from fresh and decaying strawberries.
Acyloxymethyl esters of isophosphoramide mustard as new anticancer prodrugs.
Sensitive thermal transitions of nanoscale polymer samples using the bimetallic effect: application to ultra-thin polythiophene.
[(2S,3aR,6aR)-5-Oxohexa-hydro-furo[3,2-b]furan-2-yl]methyl acetate.
A highly productive, whole-cell DERA chemoenzymatic process for production of key lactonized side-chain intermediates in statin synthesis.
Copper nanoparticles decorated inside or outside carbon nanotubes used for methyl acetate hydrogenation.
Revisiting the mechanism of neutral hydrolysis of esters: water autoionization mechanisms with acid or base initiation pathways.
Examining the risk of methanol poisoning from methyl acetate-containing products.
Cleavage of ether, ester, and tosylate C(sp3)-O bonds by an iridium complex, initiated by oxidative addition of C-H bonds. Experimental and computational studies.
Highly correlated ab initio study of the far infrared spectra of methyl acetate.
Optimization of biodiesel production by supercritical methyl acetate.
High-temperature measurements of the reactions of OH with small methyl esters: methyl formate, methyl acetate, methyl propanoate, and methyl butanoate.
Catalytic behavior and reaction routes of MEK oxidation over Pd/ZSM-5 and Pd-Ce/ZSM-5 catalysts.
Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation.
The synthesis of the pyranonaphthoquinones dehydroherbarin and anhydrofusarubin using Wacker oxidation methodology as a key step and other unexpected oxidation reactions with ceric ammonium nitrate and salcomine.
Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of methyl acetate.
Methyl 2-{6-[(1-meth-oxy-1-oxopropan-2-yl)amino-carbon-yl]pyridine-2-carboxamido}-propano-ate.
Revised molecular basis of the promiscuous carboxylic acid perhydrolase activity in serine hydrolases.
Design, synthesis, and biological activities of some branched carbasugars: construction of a substituted 6-oxabicyclo[3.2.1]nonane skeleton.
Characteristics of products from fast pyrolysis of fractions of waste square timber and ordinary plywood using a fluidized bed reactor.
Unraveling the mechanism of the photodeprotection reaction of 8-bromo- and 8-chloro-7-hydroxyquinoline caged acetates.
Conformations and reactions of bicyclo[3.2.1]oct-6-en-8-ylidene.
18F-labeled pyrazolo[1,5-a]pyrimidine derivatives: synthesis from 2,4-dinitrobenzamide and tosylate precursors and comparative biological evaluation for tumor imaging with positron emission tomography.
Transferable force field for carboxylate esters: application to fatty acid methylic ester phase equilibria prediction.
[(2R,3S,5R)-3-Acet-oxy-5-(5-formyl-2,4-dioxo-1,2,3,4-tetra-hydro-pyrimidin-1-yl)-2,3,4,5-tetra-hydro-furan-2-yl]methyl acetate.
High-resolution infrared spectrum of jet-cooled methyl acetate in the C=O stretching region: internal rotations of two inequivalent methyl tops.
(Acetoxy)(2-methylphenyl)methyl acetate.
Methyl 2-amino-5-bromo-benzoate.
[(2R,3S,6S)-3-Acet-yloxy-6-(1-phenyl-1H-1,2,3-triazol-4-yl)-3,6-dihydro-2H-pyran-2-yl]methyl acetate.
Quantifying temperature and flow rate effects on the performance of a fixed-bed chromatographic reactor.
Effects of peptide backbone amide-to-ester bond substitution on the cleavage frequency in electron capture dissociation and collision-activated dissociation.
Kinetics and products of the reaction of OH radicals with 3-methoxy-3-methyl-1-butanol.
(3-Phenyl-sulfanyl-1-phenyl-sulfonyl-1H-indol-2-yl)methyl acetate.
Methyl 2-[2-(2,6-dichloro-4-nitro-anilino)-3,5-dinitro-phen-yl]acetate.
Benefits of β-xylanase for wheat biomass conversion to bioethanol.
Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis.
Fuel-specific influences on the composition of reaction intermediates in premixed flames of three C5H10O2 ester isomers.
The effect of chemical surface treatments on the flexural strength of repaired acrylic denture base resin.
Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy.
First metal complexes of 6,6'-dihydroxy-2,2'-bipyridine: from molecular wires to applications in carbonylation catalysis.
Influence of surface chemistry on the adsorption of oxygenated hydrocarbons on activated carbons.
Deuteromycols A and B, two benzofuranoids from a Red Sea marine-derived Deuteromycete sp.
Comment on "A glycerol-free process to produce biodiesel by supercritical methyl acetate technology: an optimization study via response surface methodology".
[Ab initio calculations of vibrational frequencies and structures of ion pairs of perchlorate].
An engineered methanogenic pathway derived from the domains Bacteria and Archaea.
Understanding the factors affecting the activation of alkane by Cp'Rh(CO)2 (Cp' = Cp or Cp*).
Catalysis of transesterification by a nonfunctionalized metal-organic framework: acido-basicity at the external surface of ZIF-8 probed by FTIR and ab initio calculations.
Direct synthesis of ethanol from dimethyl ether and syngas over combined H-Mordenite and Cu/ZnO catalysts.
Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study.
Transesterification/acetylation of long chain alcohols with alkyl acetate.
Simultaneous enzymatic synthesis of FAME and triacetyl glycerol from triglycerides and methyl acetate.
[(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma.
[Immobilized lipase-catalyzed synthesis of biodiesel from crude cottonseed oil].
Formulation and in vitro evaluation of ketoprofen in palm oil esters nanoemulsion for topical delivery.
Thermal reconditioning characteristics of a respirator cartridge for organic vapors using humid air as the desorption gas.
Enantioselective carbonyl allylation, crotylation, and tert-prenylation of furan methanols and furfurals via iridium-catalyzed transfer hydrogenation.
Fabrication of nanostructured poly(3-thiophene methyl acetate) within poly(vinylidene fluoride) matrix: new physical and conducting properties.
Impact of a synbiotic food on the gut microbial ecology and metabolic profiles.
Oxidation products of sulfamethoxazole in ozonated secondary effluent.
Synthesis of rapeseed biodiesel using short-chained alkyl acetates as acyl acceptor.
Chemical equilibrium probed by two-dimensional IR spectroscopy: hydrogen bond dynamics of methyl acetate in water.
A glycerol-free process to produce biodiesel by supercritical methyl acetate technology: an optimization study via Response Surface Methodology.
Vibrational dynamics of hydrogen-bonded complexes in solutions studied with ultrafast infrared pump-probe spectroscopy.
Dynamic solvent effects on the thermal isomerization of zinc dithizonate.
Enzymatic conversion of sunflower oil to biodiesel in a solvent-free system: process optimization and the immobilized system stability.
Solvent-dependent conformation of amylose tris(phenylcarbamate) as deduced from scattering and viscosity data.
Origin of the change in solvation enthalpy of the peptide group when neighboring peptide groups are added.
Methyl 9H-carbazole-9-acetate.
{6-[2,5-Bis(chloro-meth-yl)-3,4-dihydroxy-tetra-hydro-furan-2-yl-oxy]-3-chloro-4,5-dihydr-oxy-3,4,5,6-tetra-hydro-2H-pyran-2-yl}methyl acetate dihydrate.
Methyl 2-(3-benzoyl-thio-ureido)acetate.
(2-Methyl-1-phenyl-sulfonyl-1H-indol-3-yl)phenyl-methyl acetate.
Kinetic modeling of methyl butanoate in shock tube.
Selective HOESY experiments for stereochemical determinations.
[Degradation of methyl tert-butyl ether (MTBE) by O3/H2O2].
Theoretical studies of the reaction of hydroxyl radical with methyl acetate.
Lipase-catalyzed biodiesel production with methyl acetate as acyl acceptor.
Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus.
Effect of oxidant-to-substrate ratios on the degradation of MTBE with Fenton reagent.
Synthesis of (2-oxoindolin-3-ylidene)methyl acetates involving a C-H functionalization process.
Dimethyl 3-acetyl-3-(1,3-benzothia-zol-2-yl)penta-nedioate.
Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries.
Investigation of N-hydroxythalidomide in vitro stability and comparison to other N-substituted derivatives.
Comprehensive separation of secondary metabolites in natural products by high-speed counter-current chromatography using a three-phase solvent system.
Specificity of sites within eight-membered ring zeolite channels for carbonylation of methyls to acetyls.
Isomer-specific fuel destruction pathways in rich flames of methyl acetate and ethyl formate and consequences for the combustion chemistry of esters.
Influence of inorganic ions on MTBE degradation by Fenton's reagent.
Degradation of methyl tertiary-butyl ether (MTBE) by anodic Fenton treatment.
Liquid chromatography/fluorescence method for emamectin B1a and desmethylamino-emamectin B1a residues in lobster tissue.
Anaerobic central metabolic pathways in Shewanella oneidensis MR-1 reinterpreted in the light of isotopic metabolite labeling.
Novel acetone metabolism in a propane-utilizing bacterium, Gordonia sp. strain TY-5.
Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating.
Three-phase solvent systems for comprehensive separation of a wide variety of compounds by high-speed counter-current chromatography.
Production of volatile compounds by Rhizopus oligosporus during soybean and barley tempeh fermentation.
Joint QTAIM and Hirshfeld study of the sigma and pi charge distribution and electron delocalization in carbonyl compounds: a comparative study with the resonance model.
Investigations on the polymorphism and pseudopolymorphism of triamcinolone diacetate.
Acaricidal activities of extracts of Kochia scoparia against Tetranychus urticae, Tetranychus cinnabarinus, and Tetranychus viennensis (Acari: Tetranychidae).
Analysing selected VVOCs in indoor air with solid phase microextraction (SPME): a case study.
[Biodegradation of methyl and ethyl acetates by immobilized Pseudomonas esterophilus cells].
Selective cleavage of methoxy protecting groups in carbohydrates.
Low-temperature dynamic light scattering. I. Structural reorganization and physical gel formation in cellulose triacetate/methyl acetate dilute solution at -99 - 45 degrees C.
Selective carbonylation of dimethyl ether to methyl acetate catalyzed by acidic zeolites.
Vibrational relaxation studies in methyl acetate: role of microenvironment and hydrodynamic forces.
Interaction of arsine with hemoglobin in arsine-induced hemolysis.
(2,3,4,4-Tetramethylcyclopentyl)methyl acetate, a sex pheromone from the obscure mealybug: first example of a new structural class of monoterpenes.
Olfactory coding in Drosophila larvae investigated by cross-adaptation.
Determination of in situ-generated dimethyldioxirane from an aqueous matrix using selected ion monitoring.
Parallel synthesis: a new approach for developing analytical internal standards. Application to the analysis of patulin by gas chromatography-mass spectrometry.
Production of volatile compounds in cheese by Pseudomonas fragi strains of dairy origin.
The full evaporation technique: a promising alternative for residual solvents analysis in solid samples.
Oxidation kinetics and effect of pH on the degradation of MTBE with Fenton reagent.
Hemiortho esters and hydrotrioxides as the primary products in the low-temperature ozonation of cyclic acetals: an experimental and theoretical investigation.
Air-water transfer of MTBE, its degradation products, and alternative fuel oxygenates: the role of temperature.
Computational studies of nucleophilic substitution at carbonyl carbon: the S(N)2 mechanism versus the tetrahedral intermediate in organic synthesis.
(+/-)-(4-Oxo-4H-chromen-2-yl)(phenyl)methyl acetate.
The processing and characterization of animal-derived bone to yield materials with biomedical applications: part 1: modifiable porous implants from bovine condyle cancellous bone and characterization of bone materials as a function of processing.
Degradation of MTBE in dilute aqueous solution by gamma radiolysis.
Double- and triple-consecutive O-insertion into tert-butyl and triarylmethyl structures.
Evaluation of the methyl ester O-methyl acetate derivative of muramic acid for the determination of peptidoglycan in environmental samples by ion-trap GC-MS-MS.
Effect of oil substitution in chiral microemulsion electrokinetic chromatography.
Sampling and analysis of volatile organic compounds in bovine breath by solid-phase microextraction and gas chromatography-mass spectrometry.
Chemical oxidative degradation of methyl tert-butyl ether in aqueous solution by Fenton's reagent.
Stereoselective synthesis of 1,2-disubstituted beta-amino alcohols by nucleophilic addition to N-tert-butanesulfinyl alpha-alkoxyaldimines.
MTBE oxidation byproducts from the treatment of surface waters by ozonation and UV-ozonation.
Separation and determination of methyl tert-butyl ether and its degradation products by a laboratory-constructed micro-cryogenic chromatographic oven.
A novel enzymatic route for biodiesel production from renewable oils in a solvent-free medium.
Synthesis of 2,4-disubstituted thiazoles from (Z)-(2-acetoxyvinyl)phenyl-lambda3-iodanes: nucleophilic substitution of alpha-lambda3-iodanyl ketones with thioureas and thioamides.
Determination of c9,t11-CLA in major human plasma lipid classes using a combination of methylating methodologies.
Mechanism of formation of hydrogen trioxide (HOOOH) in the ozonation of 1,2-diphenylhydrazine and 1,2-dimethylhydrazine: an experimental and theoretical investigation.
Photocatalytic oxidation of gaseous 2-chloroethyl ethyl sulfide over TiO2.
Degradation mechanism of t-butyl methyl ether (MTBE) in atmospheric droplets.
A convergent approach to the marine natural product eleutherobin: synthesis of key intermediates and attempts to produce the basic skeleton.
Mechanisms of transformation of the antioxidant kaempferol into depsides. Gamma-radiolysis study in methanol and ethanol.
Expression and characterization of a novel enantioselective lipase from Acinetobacter species SY-01.
Alcoholysis of acylpalladium(II) complexes relevant to the alternating copolymerization of ethene and carbon monoxide and the alkoxycarbonylation of alkenes: the importance of Cis-coordinating phosphines.
Rational determination of charge distributions for free energy calculations.
Lewis base activation of lewis acids. Addition of silyl ketene acetals to aldehydes.
Reductive activation of dioxygen for degradation of methyl tert-butyl ether by bifunctional aluminum.
Cooperative C-H...O hydrogen bonding in CO(2)-Lewis base complexes: implications for solvation in supercritical CO(2).
Isolation and characterization of process-related impurities in linezolid.
Kinetics of heat-assisted persulfate oxidation of methyl tert-butyl ether (MTBE).
Gas-phase reactivity of the O=P(OCH3)2+ phosphonium ion with aliphatic esters in a quadrupole ion trap. Spontaneous elimination of ketenes.
Evidence for the HOOO(-) anion in the ozonation of 1,3-dioxolanes: hemiortho esters as the primary products.
Magnitudes and chemical consequences of R(3)N(+)-C-H...O[double bond]C hydrogen bonding.
Simultaneous determination of fuel oxygenates and BTEX using direct aqueous injection gas chromatography mass spectrometry (DAI-GC/MS).
Evolution of the aroma profile of sherry wine vinegars during an experimental aging in wood.
Removal of acetone and methylacetate mixtures from waste gases by a trickle-bed air biofilter.
Conformation-dependent reaction thermochemistry: study of lactones and lactone enolates in the gas phase.
Catalytic, enantioselective aldol additions to ketones.
Evidence for HOOO radicals in the formation of alkyl hydrotrioxides (ROOOH) and hydrogen trioxide (HOOOH) in the ozonation of C-H bonds in hydrocarbons.
Kinetics and products of reactions of MTBE with ozone and ozone/hydrogen peroxide in water.
MTBE oxidation by conventional ozonation and the combination ozone/hydrogen peroxide: efficiency of the processes and bromate formation.
Understanding the relative acyl-transfer reactivity of oxoesters and thioesters: computational analysis of transition state delocalization effects.
Quantum chemical study of ester aminolysis catalyzed by a single adenine: a reference reaction for the ribosomal peptide synthesis.
Treatment of methylacetate waste gas using a trickle-bed air biofilter.
New insight on the origin of the unusual acidity of Meldrum's acid from ab initio and combined QM/MM simulation study.
Palladium(II)-catalyzed oxidation of aldehydes and ketones. 1. Carbonylation of ketones with carbon monoxide catalyzed by palladium(II) chloride in methanol.
Separation of apple procyanidins into different degrees of polymerization by high-speed counter-current chromatography.
A theoretical study of the uncatalyzed and BF3-assisted Baeyer-Villiger reactions.
Fractionation of apple procyanidins according to their degree of polymerization by normal-phase high-performance liquid chromatography.
Substitutes for methylene chloride as dental softening agent.
17O NMR spectroscopic characterization and the mechanism of formation of alkyl hydrotrioxides (ROOOH) and hydrogen trioxide (HOOOH) in the low-temperature ozonation of isopropyl alcohol and isopropyl methyl ether: water-assisted decomposition
A versatile preparation of alpha,beta-unsaturated lactones from homoallylic alcohols.
A method for detecting breakthrough of organic solvent vapors in a charcoal tube using semiconductor gas sensors.
Trace-level determination of polar flavour compounds in butter by solid-phase extraction and gas chromatography-mass spectrometry.
Identification and quantitation of N-(carboxymethyl)valine adduct in hemoglobin by gas chromatography/mass spectrometry.
Uptake of 10 polar organic solvents during short-term respiration.
Synergistic insulinotropic action of succinate, acetate, and glucose esters in islets from normal and diabetic rats.
Insulinotropic action of alpha-D-glucose pentaacetate: functional aspects.
The Enantiospecific Synthesis of an Isoxazoline. A RGD Mimic Platelet GPIIb/IIIa Antagonist.
Bioconversion of 7-Aminocephalosporanic Acid by Intact Rhodotorula glutinis Cells.
Breakthrough times for vapors of organic solvents with low boiling points in steady-state and pulsating flows on respirator cartridges.
Effects of methanol on styrene metabolism among workers occupationally exposed at low concentrations.
Anaerobic biodegradation of methyl esters by Acetobacterium woodii and Eubacterium limosum.
Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin.
Sensitive method for determination of nicorandil in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
[Determination of berberine in biological specimen by high performance TLC and fluoro-densitometric method].
In vitro hydrolysis of methyl acetate, a limitation in application of head-space gas-chromatography in biological monitoring of exposure.
Diffusive personal sampler for methyl acetate monitoring.
Adsorption characteristics of organic solvent vapor on activated carbon under fluctuating vapor concentrations.
Eudragit E microspheres containing bacampicillin: preparation by solvent removal methods.
[Hygienic evaluation and standardization of ester level in reservoir water].
1H NMR spin-echo spectroscopy of human erythrocytes. Transformation of exogenous compounds.
A structurally novel inhibitor of cGMP phosphodiesterase with vasodilator activity.
Immobilization of lipase from Candida cylindraceae and its use in the synthesis of menthol esters by transesterification.
[Optic neuropathy induced by thinner sniffing].
An unusual case of toluene-induced metabolic acidosis.
The effect of water on enzyme action in organic media.
Rapid quantification of 11 prostanoids by combined capillary column gas chromatography and negative ion chemical ionization mass spectrometry: application to prostanoids released from normal human embryonic lung fibroblasts WI38 in a culture medium.
Acute optic neuropathy induced by thinner sniffing: inhalation of mixed organic solvent containing methyl alcohol and methyl acetate.
Semiautomated analysis of ethanol and acetate in human plasma by head space gas chromatography.
The catalytic mechanism of serine proteases. III. An Indo-ISCRF study of the methylacetate docking in alpha-chymotrypsin.
A comparative quantum chemical study of methyl acetate and S-methyl thioacetate. Toward an understanding of the biochemical reactivity of esters of coenzyme A.
Aprotic polar solvents inducing chromosomal malsegregation in yeast interfere with the assembly of porcine brain tubulin in vitro.
[Stability of esters in the blood in vitro].
A simple procedure for rapid transmethylation of glycerolipids and cholesteryl esters.
Gas chromatographic mass spectrometric determination of 1,2,3-propanetrioltrinitrate (nitroglycerin) in human plasma using the nitrogen-15 labelled compound as internal standard.
Synthesis of naphthoquinoles as potential antitumor agents related to jacaranone.
High-performance liquid chromatography of bile pigments: separation and characterization of the urobilinoids.
The use of organic solvents in mutagenicity testing.
Mass spectrometry of the metabolites of 2-ethyl-2,3-dihydro-5-benzofuranylacetic acid.
Correlation between flame geometry and the absorbance of some elements in the presence of organic solvents.
Sampling and analysis of acetic anhydride in air.
2-methyltetrahydrofuran--lithium hexafluoroarsenate: a superior electrolyte for the secondary lithium electrode.
Quantitative determination of praziquantel in body fluids by gas liquid chromatography.
[Gas chromatographic determination of acetic acid esters in the air].
Factors affecting methionine toxicity and its alleviation in the chick.
[Phe4, Val6]antamanide crystallized from methyl acetate/n-hexane. Conformation and packing.
Arrangement of water molecules in cavities and channels of the lattice of [Phe4Val6]antamanide dodecahydrate.
[Separation and determination, using a gas-chromatographic method, of vinyl acetate, methyl acetate and methyl alcohol in industrial environments].
Volatiles produced by microorganisms isolated from refrigerated chicken at spoilage.
Conformation of uncomplexed [Phe4, Val6] antamanide crystallized from nonpolar solvents.
Purification and characterization of the nocardial acetylesterase involved in 2-butanone degradation.
The nature of the metal-ligand bonding in the complexes of ionophores with alkali metal ions. A quantum mechanical study of the N,N-dimethyl acetamide and methyl acetate interaction with Na(+) and Li(+).
The oxidation products of crude mesobilirubinogen.
METHYL ACETATE.
[Trial use of alpha-phenyl-2-piperidine methyl acetate in postoperative awakening of patients].
[Effect of alpha-phenyl-2-piperidine methyl acetate (ritalin) on stupor].
[Clinical observations on the association of reserpine with phenyl-piperidyl-2-methyl acetate HCI (ritalin) in arterial hypertension].
[Determination of the concentration of solutions by means of a system of two solvents; analysis of binary mixtures of acetone, methanol and methyl-acetate by means of titrating them with water in the presence of furfurol].
STUDIES ON ENZYME ACTION : XXXV. LIPASE ACTIONS OF EXTRACTS OF TISSUES OF RABBITS AT DIFFERENT AGES.
Publications by J-Stage
Comparative Volatile Profiles in Soy Sauce According to Inoculated Microorganisms
Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery
Thermal Reconditioning Characteristics of a Respirator Cartridge for Organic Vapors Using Humid Air as the Desorption Gas
Acute Optic Neuropathy Induced by Thinner Sniffing : Inhalation of Mixed Organic Solvent Containing Methyl Alcohol and Methyl Acetate

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C17530
HMDB (The Human Metabolome Database):HMDB31523
FooDB:FDB008125
Export Tariff Code:2915.39.9000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•it is generally mixed with acetone & methyl alcohol when used as solvent. •grade: technical; cp chemical pure: a grade designation signifying a minimum of impurities; but not 100% purity •commonly sold in combination with methanol in an 8020 methyl acetatemethanol by-product blend

General Material Information

Preferred name methyl acetate
Trivial Name Methyl acetate
Short Description acetic acid, methyl ester
Formula C3 H6 O2
CAS Number 79-20-9
FEMA Number 2676
Flavis Number 9.023
ECHA Number 201-185-2
FDA UNII W684QT396F
Nikkaji Number J1.965H
Beilstein Number 1736662
MDL MFCD00008711
COE Number 213
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 125 methyl acetate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 79-20-9 ; METHYL ACETATE
Synonyms
  • acetic acid methyl ester
  • acetic acid, methyl ester
  • devoton
  • ethanoic acid methyl ester
  • nat. methyl acetate
  • methyl acetate natural
  • methyl acetate, high purity
  • methyl acetic ester
  • methyl ester of acetic acid
  • methyl ethanoate
  • methylacetate
  • tereton
  • NSC 405071

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 74.079223632812
Specific gravity @ 25 °C
Pounds per Gallon 7.755 to 7.838
Refractive Index 1.355 to 1.365 @ 20 °C
Melting Point -98 to -97°C @ 760 mm Hg
Boiling Point 56 to 58°C @ 760 mm Hg
Boiling Point 23 to 24°C @ 200 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 368.350006 mmHg @ 25 °C
Vapor Density 2.55
Flash Point TCC Value -9.44 °C TCC
logP (o/w) 0.18
Solubility
alcohol Yes
water, 243000 mg/L @ 20 °C (exp) Yes

Organoleptic Properties

Odor Type: Ethereal
ethereal, sweet, fruity, solvent, estery, winey, cognac, rummy
General comment At 10.00 % in dipropylene glycol. ether sweet fruity
Mosciano, Gerard P&F 19, No. 5, 79, (1994) Etherial and solvent-like, estry, fruity, winey, cognac and rum
Flavor Type: Ethereal
green, ethereal, fruity, fresh, rummy, whiskey
Mosciano, Gerard P&F 19, No. 5, 79, (1994) At 60.00 ppm. Green, etherial, fruity, fresh, rum and whiskey-like

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 11 - Highly flammable.
R 36 - Irritating to eyes.
R 66 - Repeated exposure may cause skin dryness or cracking.
R 67 - Vapours may cause frowsiness and dizziness.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 29 - Do not empty into drains.
S 33 - Take precautionary measures against static discharge.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
(Moreno, 1976c)

oral-rat LD50 6970 mg/kg
(Smyth et al., 1962)

oral-rabbit LD50 3700 mg/kg
(Munch,1972)

unreported-mammal (species unspecified) LD50 214 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(8), Pg. 107, 1968.

oral-rabbit LD50 3705 mg/kg
Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972.

oral-rat LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 859, 1979.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 859, 1979.

skin-guinea pig LD50 > 20 ml/kg
National Technical Information Service. Vol. OTS0556681

subcutaneous-cat LDLo 3000 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

skin-guinea pig LD50 > 20 mL/kg
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

subcutaneous-guinea pig LDLo 3000 mg/kg
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

skin-rabbit LDLo 8000 mg/kg
Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 18, Pg. 45, 1943.

Inhalation Toxicity:
inhalation-cat LCLo 67000 mg/m3/1H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

inhalation-human TCLo 15000 mg/m3
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: COUGH
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

inhalation-mouse LCLo 34000 mg/m3/4H
BEHAVIORAL: GENERAL ANESTHETIC
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

inhalation-rat LCLo 32000 ppm/4H
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

Safety in use information

Category:
cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for methyl acetate usage levels up to:
5.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 460.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -14.00000
beverages(nonalcoholic): -28.00000
beverages(alcoholic): -0.20000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -29.00000
fruit ices: -29.00000
gelatins / puddings: -0.10000
granulated sugar: --
gravies: --
hard candy: -11.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 2, Revision 1 (FGE.02) : Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species
View page or View pdf

Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):79-20-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6584
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WISER:UN 1231
WGK Germany:1
methyl acetate
Chemidplus:0000079209
EPA/NOAA CAMEO:hazardous materials
RTECS:79-20-9