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methyl ortho-anisate

Chemical Structure

General Material Information

Preferred name methyl ortho-anisate
Trivial Name Methyl 2-methoxybenzoate
Short Description methyl o-methoxybenzoate
Formula C9 H10 O3
CAS Number 606-45-1
FEMA Number 2717
Flavis Number 9.796
ECHA Number 210-118-6
FDA UNII SB18J2MCQL
Nikkaji Number J47.046E
Beilstein Number 2207356
MDL MFCD00008423
COE Number 2192
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 880 methyl o-methoxybenzoate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 606-45-1 ; METHYL O-METHOXYBENZOATE
Synonyms
  • o- anisic acid methyl ester
  • ortho- anisic acid methyl ester
  • benzoic acid, 2-methoxy-, methyl ester
  • dimethyl salicylate
  • 2-methoxy-benzoic acid methyl ester
  • 2-methoxybenzoic acid methyl ester
  • o- methoxybenzoic acid methyl ester
  • ortho- methoxybenzoic acid methyl ester
  • o- methoxymethyl benzoate
  • ortho- methoxymethyl benzoate
  • methyl 2-methoxybenzoate
  • methyl o-anisate
  • methyl o-methoxy benzoate
  • methyl o-methoxybenzoate
  • methyl ortho anisate
  • methyl ortho-methoxybenzoate
  • methyl salicylate o-methyl ether
  • methyl salicylate ortho-methyl ether
  • methyl-2-methoxy benzoate
  • o-Anisic acid, methyl ester
  • Benzoic acid, o-methoxy-, methyl ester
  • o-Methoxybenzoic acid methyl ester
  • 2-Methoxybenzoic acid methyl ester
  • NSC 406256
  • Methyl 2-anisate

US / EU / FDA / JECFA / FEMA / Scholar / Patents

Google Scholar Start search
Google Books Start search
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Perfumer & Flavorists Start search
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PubMeb Start search
NCBI Start search

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB32605
FooDB:FDB010545
Export Tariff Code:2918.99.3500
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 166.17630004883
Specific gravity @ 25 °C
Pounds per Gallon 9.619 to 9.644
Refractive Index 1.532 to 1.535 @ 20 °C
Melting Point 48 to 49°C @ 760 mm Hg
Boiling Point 254 to 255°C @ 760 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 0.029 mmHg @ 25 °C
Flash Point TCC Value 110 °C TCC
logP (o/w) 2.04
Solubility
alcohol Yes
dipropylene glycol Yes
water, 1160 mg/L @ 25 °C (est) Yes
water No
Stability
cream Unspecified
hair spray Unspecified
lipstick Unspecified
lotion Unspecified
non-discoloring in most media Unspecified
powder Unspecified
shampoo Unspecified
soap Unspecified

Organoleptic Properties

Odor Type: Herbal
herbal, floral, hyacinth, cananga, fruity, currant black currant
General comment At 100.00 %. herbal floral hyacinth cananga fruity blackcurrant

Occurrences

Potential Uses

Applications
Odor purposes Berry, Currant black currant, Fungus, Melon, Raspberry, Strawberry, Wintergreen
Flavoring purposes Nut, Savory, Soup, Spinach, Vegetable
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3800 mg/kg
(Moreno, 1982l)

oral-rat LD50 3800 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 385, 1988.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 385, 1988.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for methyl ortho-anisate usage levels up to:
1.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 49.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 8.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -40.00000
beverages(nonalcoholic): -12.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -9.00000
fruit ices: -9.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -30.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):606-45-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61151
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
methyl 2-methoxybenzoate
Chemidplus:0000606451
RTECS:DH3549000 for cas# 606-45-1