woody cyclohexanone

Woody cyclohexanone, also known by its trivial name 4-(1-ethoxyethenyl)-3,3,5,5-tetramethylcyclohexanone, is a synthetic fragrance molecule with the molecular formula C₁₄H₂₄O₂. It appears as a liquid and is recognized for its distinctive woody odor that includes amber and tobacco undertones. The compound is commonly called kephalis, among other synonyms, and is widely used in perfumery as a heart or base note ingredient. It is listed in chemical registries such as PubChem (CID 118292). Sourced mainly by industrial synthesis, woody cyclohexanone is valued for its versatility in creating rich, warm fragrance profiles.

Woody cyclohexanone is not naturally occurring but is synthesized for use as a fragrance agent. It serves as a key ingredient in perfuming agents where it imparts medium-strength, warm woody, amber, herbal, and tobacco notes. The odorant blends well with floral components such as jasmine, rose, and violet, as well as woody-aldehydic and masculine accords. It is known for its high substantivity, lasting up to 96 hours at 100% concentration. This compound is included under the fragrance material safety guidelines established by IFRA (Global), which supports its controlled use in cosmetic formulations.

With a molecular weight of approximately 224.34 g/mol, woody cyclohexanone has a moderate estimated octanol-water partition coefficient (log P) of 4.05, indicating significant lipophilicity. Its vapor pressure at 25 °C is low, measured at 0.003 mmHg, reflecting low volatility. The compound has good solubility in alcohol and moderate solubility in water, at about 261 mg/L at 20 °C. Its flashpoint is around 122 °C (261 °F) by Tag Closed Cup method, suggesting relative stability under typical handling conditions. Woody cyclohexanone exhibits good stability in alcoholic solutions and soaps but shows moderate to poor stability in alkaline or bleach-containing environments. Such properties influence its formulation versatility, particularly in diffusion-based and perfuming products.

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Safety information

European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
10 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg Food and Chemical Toxicology. Vol. 20, Pg. 835, 1982.
Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg Food and Chemical Toxicology. Vol. 20, Pg. 835, 1982.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for woody cyclohexanone usage levels up to:
	8.0000 % in the fragrance concentrate.
Recommendation for woody cyclohexanone flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

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EPA Substance Registry Services (TSCA):36306-87-3

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :118292

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

4-(1-ethoxyethenyl)-3,3,5,5-tetramethylcyclohexan-1-one

Chemidplus:0036306873