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phenoxyacetic acid

Chemical Structure

General Material Information

Preferred name phenoxyacetic acid
Trivial Name Phenoxyacetic acid
Short Description 2-(phenoxy)acetic acid
Formula C8 H8 O3
CAS Number 122-59-8
FEMA Number 2872
Flavis Number 8.049
ECHA Number 204-556-7
FDA UNII YRC253429Q
Nikkaji Number J5.358I
Beilstein Number 0907949
MDL MFCD00004296
COE Number 2005
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1026 phenoxyacetic acid
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 122-59-8 ; PHENOXYACETIC ACID
Synonyms
  • acetic acid, 2-phenoxy-
  • acetic acid, phenoxy-
  • glycol acid phenyl ether
  • glycolic acid phenyl ether
  • glycollic acid phenyl ether
  • phenoxacetic acid
  • phenoxy acetic acid
  • phenoxy-acetic acid
  • 2-( phenoxy)acetic acid
  • 2-phenoxyacetic acid
  • phenoxyaceticacid
  • phenoxyethanoic acid
  • o- phenyl glycolic acid
  • ortho- phenyl glycolic acid
  • o- phenylglycolic acid
  • 2-(phenoxy)acetic acid
  • 2-Phenoxyacetic acid
  • POA
  • NSC 9810
  • 2-Phenyloxyacetic acid

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Perfumer & Flavorists Start search
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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C02181
HMDB (The Human Metabolome Database):HMDB31609
FooDB:FDB008245
Export Tariff Code:2918.17.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 152.14935302734
Melting Point 99 to 103°C @ 760 mm Hg
Vapor Pressure 0.001 mmHg @ 25 °C
Flash Point TCC Value 115 °C TCC
logP (o/w) 1.34
Solubility
alcohol Yes
water, 12000 mg/L @ 10 °C (exp) Yes
water No

Organoleptic Properties

Odor Type: Honey
sour, sweet
General comment At 1.00 % in propylene glycol. sour sweet

Occurrences

Potential Uses

Applications
Flavoring purposes Chocolate cocoa
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
2 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 1500 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 94, 1990.

intravenous-mouse LD50 1000 mg/kg
Pharmazie. Vol. 18, Pg. 642, 1963.

oral-mouse LD50 3750 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981.

oral-rabbit LD50 > 200 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979.

intraperitoneal-rat LD50 323 mg/kg
Travaux de la Societe de Pharmacie de Montpellier. Vol. 34, Pg. 121, 1974.

unreported-guinea pig LD50 1400 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for phenoxyacetic acid usage levels up to:
0.2000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 30.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -2.20000
beverages(nonalcoholic): -0.37000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -2.20000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 53 (FGE.53): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and one phenoxyethyl ester evaluated in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 53, Revision 1 (FGE.53Rev1): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) FGE.23Rev1 (2008)
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):122-59-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :19188
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(phenoxy)acetic acid
Chemidplus:0000122598
EPA/NOAA CAMEO:hazardous materials
RTECS:AJ2230000 for cas# 122-59-8