We have found
46590
results matching your criteria.
Please wait while we search...
WS-3
General Material Information
| Preferred name | WS-3 |
| Trivial Name | N-Ethyl-p-menthane-3-carboxamide |
| Short Description | N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide |
| Formula | C13 H25 N O |
| CAS Number | 39711-79-0 |
| FEMA Number | 3455 |
| Flavis Number | 16.013 |
| ECHA Number | 254-599-0 |
| FDA UNII | 6S7S02945H |
| Nikkaji Number | J261.435I |
| MDL | MFCD00130071 |
| COE Number | 2298 |
| xLogP3-AA | 3.50 (est) |
| NMR Predictor | External link |
| JECFA Food Flavoring | 1601 N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 39711-79-0 ; N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| Leffingwell: | Chirality or Article |
| N-ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 39711-79-0 |
| Pubchem (cid): | 62907 |
| Pubchem (sid): | 135020214 |
| Publications by Info | |
| aliphatic and aromatic amines and amides | |
| Publications by PubMed | |
| Release kinetics of actives from chewing gums into saliva monitored by direct analysis in real time mass spectrometry. | |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB37834 |
| FooDB: | FDB016984 |
| Export Tariff Code: | 2924.29.9500 |
| ChemSpider: | View |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 211.34844970703 |
| Melting Point | 91 to 93°C @ 760 mm Hg |
| Vapor Pressure | 8.5E-5 mmHg @ 25 °C |
| Flash Point TCC Value | 100 °C TCC |
| logP (o/w) | 3.717 est |
| Solubility | |
| alcohol | Yes |
| water, 21.38 mg/L @ 25 °C (est) | Yes |
| water | No |
Organoleptic Properties
| Odor Type: Minty | |
| mentholic, minty, alcoholic, cooling | |
| Odor strength | low |
| Luebke, William tgsc, (2009) | At 25.00 % in dipropylene glycol. mild mentholic minty |
| Mosciano, Gerard P&F 25, No. 6, 26, (2000) | At 10.00 %. Virtually odorless being slightly alcoholic and cooling |
| Flavor Type: Cooling | |
| mentholic, cooling, minty, eucalyptus, camphoreous | |
| Luebke, William tgsc, (2009) | Mentholic cooling minty eucalyptus camphoreous |
| Mosciano, Gerard P&F 25, No. 6, 26, (2000) | At 10.00 - 100.00 ppm. Intense lingering cooling trigeminal effect. The cooling sensation slowly but steadily grows to a lingering cooling mouth feel with a slightly camphoraceous and minty character |
| General comment | INTENSE LINGERING COOLING EFFECT |
Potential Uses
| Applications | |
| Flavoring purposes | Beverage , Mint , Spice , Tonic |
| Other purposes | Oral care agents |
| Cosmetic purposes | Tonic |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 36 - Irritating to eyes. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| flavoring agents | |||
| Recommendation for WS-3 usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.40 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 127.00 (μg/capita/day) | ||
| Threshold of Concern: | 90 (μg/person/day) | ||
| Structure Class: | III | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 9. Update in publication number(s): 18, 25 | |||
| Click here to view publication 9 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | - | |
| beverages(nonalcoholic): | 10.00000 | 10.00000 | |
| beverages(alcoholic): | 10.00000 | 10.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 1400.00000 | 2000.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | 10.00000 | 10.00000 | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 10.00000 | 10.00000 | |
| fruit ices: | 10.00000 | 10.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 100.00000 | 150.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | 10.00000 | 10.00000 | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | 66.00000 | 100.00000 | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):39711-79-0 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :62907 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| N-ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide |
| Chemidplus:0039711790 |