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laevo-glutamine

Chemical Structure

General Material Information

Preferred name laevo-glutamine
Trivial Name L-Glutamine
Short Description (2S)-2,5-diamino-5-oxopentanoic acid
Formula C5 H10 N2 O2
CAS Number 56-85-9
FEMA Number 3684
Flavis Number 17.007
ECHA Number 200-292-1
FDA UNII 0RH81L854J
Nikkaji Number J9.170G
Beilstein Number 1723797
MDL MFCD00008044
COE Number 17007
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1430 L-glutamine
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 56-85-9 ; L-GLUTAMINE
Synonyms
  • (2S)-2-amino-4-carbamoyl butanoic acid
  • (2S)-2-amino-4-carbamoylbutanoic acid
  • (2S)-2,5-diamino-5-oxopentanoic acid
  • (2S)-2,5-diamino-5-oxopentanoic acid
  • (S)-(+)-glutamine
  • (S)-2,5-diamino-5-oxo-pentanoic acid
  • (S)-2,5-diamino-5-oxopentanoic acid
  • 2-aminoglutaramic acid, L-
  • 2,5-diamino-5-oxopentanoic acid, (S)-
  • ajipure glutamine
  • cebrogen
  • glutamic acid 5-amide
  • glutamic acid amide
  • glutamine-S
  • glutamine, L-
  • L-aminoglutaramic acid
  • L-glutamic acid 5-amide
  • L-glutamic acid g-amide
  • L-glutamic acid gamma-amide
  • L-glutamic acid-5-amide
  • L-glutamid
  • L-glutamide
  • L-glutamin
  • L-glutamine
  • L-glutamine (fermented)
  • L-glutamine FCC
  • L-(+)-glutamine
  • L-2-aminoglutaramic acid
  • L-2-aminoglutaramidic acid
  • laevo-glutamic acid gamma-amide
  • laevo-glutamic acid-5-amide
  • laevo-glutamide
  • laevo-(+)-glutamine
  • laevo-2-aminoglutaramidic acid
  • levoglutamid
  • levoglutamide
  • levoglutamina
  • miglu-P
  • nutrestore
  • pentanoic acid, 2,5-diamino-5-oxo-, (S)-
  • stimulina
  • Glumin
  • Glutamine
  • L-Glutamic acid γ-amide
  • γ-Glutamine
  • 2-Aminoglutaramic acid
  • Glumin (amino acid)
  • NSC 27421
  • Aesgen 14
  • Acustasin
  • Saforis
  • Endari
  • 12: PN: WO2021055880 SEQID: 13 claimed protein
  • 47: PN: WO2022204326 SEQID: 81 claimed protein
  • MeSH ID: D005973

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00064
HMDB (The Human Metabolome Database):HMDB00641
FooDB:FDB012164
YMDB (Yeast Metabolome Database):YMDB00002
Export Tariff Code:2924.19.8000
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 130.14709472656
Melting Point 185 to 205°C @ 760 mm Hg
Flash Point TCC Value 93.33 °C TCC
logP (o/w) -1.576 est
Solubility
propylene glycol Yes
water, 4.221e+004 mg/L @ 25 °C (est) Yes
water, 4.13E+04 mg/L @ 25 °C (exp) Yes

Organoleptic Properties

Odor Type: Milky
milky, custard, cocoa, oily
Odor strength none
Luebke, William tgsc, (2007) At 100.00 %. very mild milky custard cocoa oily
Flavor Type: Sweet
sweet
General comment Slightly sweet

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-man TDLo 27 mg/kg/1W-I
BEHAVIORAL: EUPHORIA
American Journal of Psychiatry. Vol. 141, Pg. 1302, 1984.

oral-mouse LD50 21700 mg/kg
Drugs in Japan Vol. 6, Pg. 228, 1982.

oral-rat LD50 7500 mg/kg
Drugs in Japan Vol. 6, Pg. 228, 1982.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
special dietary and nutritional additives
Recommendation for laevo-glutamine usage levels up to:
not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 13.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
Click here to view publication 13
average usual ppmaverage maximum ppm
baked goods: -350.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -350.00000
milk products: --
nut products: -350.00000
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: -350.00000
snack foods: --
soft candy: -350.00000
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Amino acids from chemical group 34 Flavouring Group Evaluation 26, Revision 1 - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 79, (FGE.79)[1] - Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
View page or View pdf

Safety and efficacy of l-glutamine produced using Corynebacterium glutamicum NITE BP-02524 for all animal species
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):56-85-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5961
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(2S)-2,5-diamino-5-oxopentanoic acid
Chemidplus:0000056859
RTECS:MA2275100 for cas# 56-85-9