phenyl glycol diacetate

Phenyl glycol diacetate, also known by its IUPAC name 1-phenyl-1,2-ethanediol diacetate, is an organic ester with a molecular formula of C₁₂H₁₄O₄. This compound appears as a clear liquid and is characterized by a floral odor reminiscent of gardenia, muguet, and hyacinth, combined with balsamic and honey-like undertones. It is recognized under various synonyms including (2-acetyl oxy-1-phenyl ethyl) acetate and beta-hydroxyphenethyl alcohol diacetate. Phenyl glycol diacetate is sourced mainly through synthetic esterification processes involving phenyl-substituted ethanediols and acetic acid derivatives. For chemical reference, this compound is cataloged in public chemical databases such as PubChem. It finds primary application in fragrance formulations where its floral-balsam notes contribute to the olfactory complexity of perfumes and cosmetics.

Phenyl glycol diacetate does not occur naturally in significant amounts but is predominantly produced synthetically for use in fragrance applications. It is valued for imparting floral accords, including gardenia, hyacinth, lily of the valley, balsam, and vetiver nuances. Its use is especially relevant in fine fragrances and personal care products. According to IFRA (Global) standards, usage levels are typically recommended up to 10% in fragrance concentrates to ensure safety and olfactory performance. Phenyl glycol diacetate is not approved for flavor applications. Its moderate volatility and characteristic scent profile make it a versatile component in complex fragrance blends.

Phenyl glycol diacetate manifests as a moderately dense liquid with a specific gravity ranging approximately from 1.116 to 1.125 at temperatures of 20 to 25 °C. The refractive index falls between 1.492 and 1.497 at 20 °C, indicating its optical density. It exhibits a low vapor pressure of about 0.001 mmHg at 25 °C, producing low volatility and good persistence in formulations. The compound possesses an estimated partition coefficient (log P) around 1.5 to 1.8, indicating a balance of lipophilicity suitable for fragrance solubility in oils and alcohols. Its flash point is about 100 °C (212 °F), implying relative stability under typical handling conditions. Solubility studies show phenyl glycol diacetate is soluble in alcohol solvents and has limited water solubility (approximately 607.4 mg/L at 25 °C). These properties influence its formulation compatibility and olfactory release profile in consumer products.

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Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for phenyl glycol diacetate usage levels up to:
	10.0000 % in the fragrance concentrate.
Recommendation for phenyl glycol diacetate flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

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Toxicology Citations:Search

EPA Substance Registry Services (TSCA):6270-03-7

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :95008

National Institute of Allergy and Infectious Diseases:Data

(2-acetyloxy-1-phenylethyl) acetate

Chemidplus:0006270037