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(±)-camphor
General Material Information
| Preferred name | (±)-camphor |
| Trivial Name | (±)-Camphor |
| Short Description | DL-camphor |
| Formula | C10 H16 O |
| CAS Number | 76-22-2 |
| Deleted CAS Number | 21368-68-3 |
| FEMA Number | 4513 |
| ECHA Number | 200-945-0 |
| FDA UNII | 5TJD82A1ET |
| Nikkaji Number | J4.364H |
| Beilstein Number | 1907611 |
| MDL | MFCD00074738 |
| COE Number | 140 |
| xLogP3-AA | 2.20 (est) |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 21368-68-3 ; DL-CAMPHOR |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C18369 |
| HMDB (The Human Metabolome Database): | Search |
| FooDB: | FDB029685 |
| Export Tariff Code: | 2914.29.3100 |
| MedlinePlusSupp: | View |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •grades: technical (synthetic); usp. •alcanfor •natricaria camphor •root bark oil •twenty grams of vicks vaporub, 10 ml of campho-phenique, and 16 ml of vicks vaposteam each contain about 1 g of camphor. •preparations of camphor for local application include camphor spirit (10% in alcohol) and camphorated parachlorophenol (35% parachlorophenol and 65% camphor)andas a 0.1 to 3% lotion •trade names: balmosa cream (camphor 4%, menthol 2%, methyl salicylate 4%, capsicum oleoresin 0.035%); boots vapor rub; earex (almond oil 33.33%, arachis oil 33.33%, camphor oil 33.33%); mentholatum vapor rub (camphor 9%, menthol 1.35%, methyl salicylate 0.33%); nasciodine (iodine 1.26%, menthol 0.59%, methyl salicylate 3.87%, turpentine oil 3.87%, camphor 3.87%); nicobrevin (methyl valerate 100 mg, quinine 15 mg, camphor 10 mg, eucalyptus oil 10 mg); pr heat spray (camphor 0.62%, methyl salicylate 1.24%, ethyl nicotinate 1.1%); radian-b -liniment and spray (menthol 1.4%, camphor 0.6%, ammonium salicylate 1%, salicylic acid 0.54%), -rub (menthol 2.54%, camphor 1.43%, methyl salicylate 0.42%, capsicin 0.042%), -cream (camphor 1.43%, menthol 2.54%, methyl salicylate 0.42%, oleoresin capsicum 0.005%); tixylix inhalant (camphor 60 mg, menthol 2 mg, turpentine oil 50 mg, eucalyptus oil 20 mg); vicks inhaler (camphor 41.54%, menthol 41.54%, siberian pine needle oil 4.65%); vicks sinex (oxymetazoline 0.05%, menthol 0.025%, camphor 0.015%, eucalyptus oil 0.0075%); vicks vaporub (menthol 2.82%, camphor 5.46%, eucalyptus oil 1.35%, turpentine oil 4.71%). •non-proprietary preparations: camphor linctus compound (camphor spirit compound 1 ml, glycerol 1.5 ml, tolu syrup to 5 ml); camphor liniment (camphor 20% ww in arachis oil) (a.k.a. camph. lin; camphorated oil); camphor spirit (camphor 10 g, alcohol to 100 ml); camphor spirit compound (camphor 300 mg, benzoic acid 500 mg, anise oil 0.3 ml, alcohol (60%) to 100 ml); concentrated camphor water (camphor 4 g, alcohol (90%) 60 ml, water to 100 ml). | |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 152.23672485352 |
| Melting Point | 176 to 177°C @ 760 mm Hg |
| Boiling Point | 204 to 205°C @ 760 mm Hg |
| Boiling Point | 120 to 121°C @ 50 mm Hg |
| Vapor Pressure | 0.65 mmHg @ 25 °C |
| Vapor Density | 5.2 |
| Flash Point TCC Value | 64.44 °C TCC |
| logP (o/w) | 2.38 |
| Solubility | |
| alcohol | Yes |
| water, 1600 mg/L @ 25 °C (exp) | Yes |
Organoleptic Properties
| Odor Type: Camphoreous | |
| camphoreous | |
| General comment | At 10.00 % in dipropylene glycol. camphoreous |
| Flavor Type: Camphoreous | |
| camphoreous | |
| General comment | Camphoreous |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Other purposes | Denaturants, Film formers, Plasticisers |
| Cosmetic purposes | Denaturants, Fragrance, Plasticisers |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. R 40 - Limited evidence of a carcinogenic effect. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-mouse LD50 1310 mg/kg Shika Gakuho. Journal of Dentistry. Vol. 75, Pg. 934, 1975. intraperitoneal-mouse LD50 3000 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: REGIDITY American Journal of Pathology. Vol. 30, Pg. 857, 1954. intraperitoneal-cat LDLo 400 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. unreported-child LDLo 100 mg/kg Yakkyoku. Pharmacy. Vol. 31, Pg. 1499, 1980. oral-child TDLo 51 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD American Journal of Emergency Medicine. Vol. 7, Pg. 41, 1989. oral-dog LDLo 800 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. unreported-man LDLo 29 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-rabbit LDLo 2000 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: REGIDITY American Journal of Pathology. Vol. 30, Pg. 857, 1954. intraperitoneal-rat LDLo 900 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 275, 1939. | |
| Dermal Toxicity: | |
| subcutaneous-rat LD50 70 mg/kg "Ueber die Pharmakologische Wirkung eines dem Pentamethylentetrazol Vol. -, Pg. -, 1934. subcutaneous-frog LDLo 240 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903. subcutaneous-mouse LDLo 200 mg/kg BEHAVIORAL: EXCITEMENT "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933. | |
| Inhalation Toxicity: | |
| inhalation-mouse LCLo 400 mg/m3/3H BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 22(11), Pg. 83, 1957. | |
Safety in use information
| Category: | |||
| flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for (±)-camphor usage levels up to: | |||
| 4.0000 % in the fragrance concentrate. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 24 | |||
| Click here to view publication 24 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 1.00000 | 10.00000 | |
| beverages(nonalcoholic): | 0.01000 | 0.20000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 20.00000 | 100.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | 1.00000 | 10.00000 | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | 0.02000 | 2.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 5.00000 | 50.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Authority (EFSA) reference(s): |
| Camphor in flavourings and other food ingredients with flavouring properties - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):76-22-2 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :2537 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 2717 |
| WGK Germany:1 |
| 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one |
| Chemidplus:0000076222 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:76-22-2 |