2-methyl-5,7-dihydrofuro-[3,4-d]-pyrimidine

2-methyl-5,7-dihydrofuro-[3,4-d]-pyrimidine is a heterocyclic organic compound characterized by a bicyclic structure combining furan and pyrimidine rings. It appears as a colorless to pale substance and bears the molecular formula C₇H₈N₂O with a molecular weight of approximately 136.15 g/mol. This compound is also known by synonyms including 5,7-dihydro-2-methylfuro[3,4-d]pyrimidine and 2-methyl-5H,7H-furo[3,4-d]pyrimidine. Sensory examination reveals sweet popcorn-like odor and flavor notes when diluted appropriately. It is registered in chemical databases such as PubChem. Industrial interest is primarily informational since the compound is not applied commercially in the fragrance or flavor sectors but may be referenced for sensory evaluation or chemical research purposes.

This compound is not naturally known to occur in biological systems or common natural extracts. Its detectable popcorn odor attributes suggest it could conceptually relate to aroma compounds formed during thermal processing or Maillard-type reactions. However, 2-methyl-5,7-dihydrofuro-[3,4-d]-pyrimidine is currently an informational reference substance only and is not employed in fragrance or flavor formulations. Regulatory frameworks such as FEMA (US) list this compound without assigned usage levels, reflecting its absence from commercial flavor and fragrance uses. Researchers in flavor chemistry might study it to understand sensory profiles, but practical applications remain unestablished.

The compound's structural features give it moderate polarity due to nitrogen and oxygen heteroatoms in the fused ring system. It is predicted to be water-soluble with an estimated solubility of approximately 57,130 mg/L at 25 °C, indicating significant hydrophilicity. This property could influence its behaviour in aqueous formulations or analytical preparations. The molecular weight near 136 Da and bicyclic structure suggest moderate volatility, consistent with volatile flavor or odor compounds. The lack of GHS hazard classifications implies no significant acute toxicity according to current assessments. These properties collectively indicate a compound suited for laboratory study rather than practical formulation inclusion.

	2-methyl-5,7-dihydrofuro[3,4-d]pyrimidine
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	21554588
Pubchem (sid):	315565376

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
information only not used for fragrances or flavors
Recommendation for 2-methyl-5,7-dihydrofuro-[3,4-d]-pyrimidine usage levels up to:
	not for fragrance use.
Recommendation for 2-methyl-5,7-dihydrofuro-[3,4-d]-pyrimidine flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

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Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :21554588

National Institute of Allergy and Infectious Diseases:Data

2-methyl-5,7-dihydrofuro[3,4-d]pyrimidine