We have found 46587 results matching your criteria.
Please wait while we search...

General Material Information

Preferred name (E)-cinnamaldehyde
Trivial Name trans-Cinnamaldehyde
Short Description trans-3-phenyl-2-propenal
Formula C9 H8 O
CAS Number 14371-10-9
FEMA Number 2286
FDA UNII SR60A3XG0F
Nikkaji Number J43.393D
Beilstein Number 1071571
MDL MFCD00007000
Bio Activity Summary External link
NMR Predictor External link
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
Synonyms
  • trans- cinnamaldehyde
  • (E)- cinnamic aldehyde
  • trans- cinnamic aldehyde
  • (E)-3-phenyl-2-propenal
  • trans-3-phenyl-2-propenal
  • (E)-3-phenylprop-2-enal
  • 2-propenal, 3-phenyl-, (2E)-
  • (E)-3-phenylprop-2-enal
  • 2-Propenal, 3-phenyl-, (2E)-
  • Cinnamaldehyde, (E)-
  • 2-Propenal, 3-phenyl-, (E)-
  • (2E)-3-Phenyl-2-propenal
  • trans-Cinnamaldehyde
  • trans-Cinnamic aldehyde
  • trans-3-Phenyl-2-propenal
  • trans-Cinnamylaldehyde
  • (E)-3-Phenylpropenal
  • E-Cinnamyl aldehyde
  • trans-3-Phenylpropenal
  • trans-Benzenepropenal
  • (E)-3-Phenylacrolein
  • (E)-3-Phenylprop-2-enone
  • (E)-3-Phenylprop-2-en-1-al

US / EU / FDA / JECFA / FEMA / Scholar / Patents

Google Scholar Start search
Google Books Start search
Google Patents Start search
Perfumer & Flavorists Start search
EU Patents Start search
PubMeb Start search
NCBI Start search

Literature & References

(E)-3-phenylprop-2-enal
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):637511
Pubchem (sid):134990107
Flavornet:14371-10-9
Pherobase:View
Publications by Info
Cinnamaldehyde
Publications by PubMed
Changes in Quality Characteristics of Pork Patties Containing Multilayered Fish Oil Emulsion during Refrigerated Storage.
Appetite-enhancing Effects of trans-Cinnamaldehyde, Benzylacetone and 1-Phenyl-2-butanone by Inhalation.
Cinnamomum cassia Suppresses Caspase-9 through Stimulation of AKT1 in MCF-7 Cells but Not in MDA-MB-231 Cells.
Effect of 2-Propanol on the Transfer Hydrogenation of Aldehydes by Aqueous Sodium Formate using a Rhodium(I)-sulfonated Triphenylphosphine Catalyst.
Synergism between carvacrol or thymol increases the antimicrobial efficacy of soy sauce with no sensory impact.
trans-Cinnamaldehyde stimulates mitochondrial biogenesis through PGC-1α and PPARβ/δ leading to enhanced GLUT4 expression.
Antibiofilm activity of trans-cinnamaldehyde, p-coumaric, and ferulic acids on uropathogenic Escherichia coli.
Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum).
Preparation of Chitosan-Alginate Nanoparticles for Trans-cinnamaldehyde Entrapment.
Application of Volatile Antifungal Plant Essential Oils for Controlling Pepper Fruit Anthracnose by Colletotrichum gloeosporioides.
Evaluation of the combined effect of thymol, carvacrol and (E)-cinnamaldehyde on Amblyomma sculptum (Acari: Ixodidae) and Dermacentor nitens (Acari: Ixodidae) larvae.
The Effect of Chemical Composition and Bioactivity of Several Essential Oils on Tenebrio molitor (Coleoptera: Tenebrionidae).
Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates.
Controlling Aspergillus flavus and Aspergillus parasiticus growth and aflatoxin production in poultry feed using carvacrol and trans-cinnamaldehyde.
Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance.
Identification of Aroma-active Compounds in Essential Oil from Uncaria Hook by Gas Chromatography- Mass Spectrometry and Gas Chromatography-Olfactometry.
Joint Experimental, in Silico, and NMR Studies toward the Rational Design of Iminium-Based Organocatalyst Derived from Renewable Sources.
Structure determination of trans-cinnamaldehyde by broadband microwave spectroscopy.
Efficacy of fumigation with Trans-cinnamaldehyde and eugenol in reducing Salmonella enterica serovar Enteritidis on embryonated egg shells.
Fumigant Activity of 6 Selected Essential Oil Compounds and Combined Effect of Methyl Salicylate And Trans-Cinnamaldehyde Against Culex pipiens pallens.
A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde.
Effect of a Vietnamese Cinnamomum cassia essential oil and its major component trans-cinnamaldehyde on the cell viability, membrane integrity, membrane fluidity, and proton motive force of Listeria innocua.
In-feed supplementation of trans-cinnamaldehyde reduces layer-chicken egg-borne transmission of Salmonella enterica serovar enteritidis.
In vitro evaluation of the activity of thiosemicarbazone derivatives against mycotoxigenic fungi affecting cereals.
Efficacies of nisin A and nisin V semipurified preparations alone and in combination with plant essential oils for controlling Listeria monocytogenes.
The antisenescence effect of trans-cinnamaldehyde on adipose-derived stem cells.
Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds.
Identification of character-impact odorants in a cola-flavored carbonated beverage by quantitative analysis and omission studies of aroma reconstitution models.
Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target.
Reduction of Salmonella on turkey breast cutlets by plant-derived compounds.
Antibacterial Mode of Action of Cinnamomum verum Bark Essential Oil, Alone and in Combination with Piperacillin, Against a Multi-Drug-Resistant Escherichia coli Strain.
Fumigant, contact, and repellent activities of essential oils against the darkling beetle, Alphitobius diaperinus.
[Chemical constituents of Jasminum giraldii and their antioxidant activity].
Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: reactivity and molecular details of the enzyme-substrate and enzyme-product interaction.
Repellent and insecticidal effects of the essential oil of Kaempferia galanga rhizomes to Liposcelis bostrychophila (Psocoptera: Liposcelidae).
In vitro biological evaluation of eight different essential oils against Trypanosoma cruzi, with emphasis on Cinnamomum verum essential oil.
Stable isotope labeling method for the investigation of protein haptenation by electrophilic skin sensitizers.
Enhanced toxicity of binary mixtures of Bacillus thuringiensis subsp. israelensis and three essential oil major constituents to wild Anopheles sinensis (Diptera: Culicidae) and Aedes albopictus (Diptera: Culicidae).
Cinnamaldehyde and cuminaldehyde thiosemicarbazones and their copper(II) and nickel(II) complexes: a study to understand their biological activity.
Antibacterial activities of plant-derived compounds and essential oils toward Cronobacter sakazakii and Cronobacter malonaticus.
Plant-derived antimicrobials reduce E. coli O157:H7 virulence factors critical for colonization in cattle gastrointestinal tract in vitro.
Activity of Cinnamomum osmophloeum leaf essential oil against Anopheles gambiae s.s.
Sub-inhibitory concentrations of trans-cinnamaldehyde attenuate virulence in Cronobacter sakazakii in vitro.
Seed-mediated synthesis of bimetallic ruthenium-platinum nanoparticles efficient in cinnamaldehyde selective hydrogenation.
Recombinant S. cerevisiae expressing Old Yellow Enzymes from non-conventional yeasts: an easy system for selective reduction of activated alkenes.
Effects of chitosan-essential oil coatings on safety and quality of fresh blueberries.
Chemical composition of essential oils from four Vietnamese species of piper (piperaceae).
A simple QuEChERS-like extraction approach for molecular chemical characterization of organic aerosols: application to nitrated and oxygenated PAH derivatives (NPAH and OPAH) quantified by GC-NICIMS.
Somatosensory and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers.
Carvacrol and trans-cinnamaldehyde reduce Clostridium difficile toxin production and cytotoxicity in vitro.
Inhibitory effect of combinations of caprylic acid and nisin on Listeria monocytogenes in queso fresco.
Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury.
Impacts of sample preparation methods on solubility and antilisterial characteristics of essential oil components in milk.
Rapid inactivation of Salmonella Enteritidis on shell eggs by plant-derived antimicrobials.
The volatile profiles of a rare apple (Malus domestica Borkh.) honey: shikimic acid-pathway derivatives, terpenes, and others.
Efficacy of plant-derived antimicrobials as antimicrobial wash treatments for reducing enterohemorrhagic Escherichia coli O157:H7 on apples.
Investigation of activity of monoterpenes and phenylpropanoids against immature stages of Amblyomma cajennense and Rhipicephalus sanguineus (Acari: Ixodidae).
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats.
Inhibitory effects of Cinnamomum burmannii Blume stem bark extract and trans-cinnamaldehyde on nasopharyngeal carcinoma cells; synergism with cisplatin.
Stimulation of suicidal erythrocyte death by trans-cinnamaldehyde.
Safety assessment of standardised methanol extract of Cinnamomum burmannii.
Repellency of cassia bark, eucalyptus, and star anise oils and their major constituents to Leptotrombidium pallidum (Acari: Trombiculidae).
An improved bioassay facilitates the screening of repellents against cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae).
Antibiofilm effect of plant derived antimicrobials on Listeria monocytogenes.
Methods for thermal stability enhancement of leaf essential oils and their main constituents from indigenous cinnamon (Cinnamomum osmophloeum).
In vitro sensitivity of poultry Brachyspira intermedia isolates to essential oil components and in vivo reduction of Brachyspira intermedia in rearing pullets with cinnamaldehyde feed supplementation.
Inactivation of Listeria monocytogenes on frankfurters by plant-derived antimicrobials alone or in combination with hydrogen peroxide.
Controlled silanization-amination reactions on the Ti6Al4V surface for biomedical applications.
Assessment of the acaricidal activity of carvacrol, (E)-cinnamaldehyde, trans-anethole, and linalool on larvae of Rhipicephalus microplus and Dermacentor nitens (Acari: Ixodidae).
Use of plant-derived antimicrobials for improving the safety of poultry products.
Induction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydes.
Enhancement of antimycotic activity of amphotericin B by targeting the oxidative stress response of Candida and cryptococcus with natural dihydroxybenzaldehydes.
Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum.
Plant-derived antimicrobials reduce Listeria monocytogenes virulence factors in vitro, and down-regulate expression of virulence genes.
In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum.
Efficacy of trans-cinnamaldehyde against Psoroptes cuniculi in vitro.
Reduction of Salmonella enterica serovar enteritidis colonization in 20-day-old broiler chickens by the plant-derived compounds trans-cinnamaldehyde and eugenol.
Kinetics of thermal destruction of Salmonella in ground chicken containing trans-cinnamaldehyde and carvacrol.
One-pot deposition of palladium on hybrid TiO2 nanoparticles and catalytic applications in hydrogenation.
The cinnamon-oil ingredient trans-cinnamaldehyde fails to target Campylobacter jejuni strain KC 40 in the broiler chicken cecum despite marked in vitro activity.
A study of four antioxidant activities and major chemical component analyses of twenty-five commonly used essential oils.
Application of liquid chromatography-direct-electron ionization-MS in an in vitro dermal absorption study: quantitative determination of trans-cinnamaldehyde.
Reagent precoated targets for rapid in-tissue derivatization of the anti-tuberculosis drug isoniazid followed by MALDI imaging mass spectrometry.
Microencapsulated antimicrobial compounds as a means to enhance electron beam irradiation treatment for inactivation of pathogens on fresh spinach leaves.
Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger.
Measuring the penetration of a skin sensitizer and its delivery vehicles simultaneously with confocal Raman spectroscopy.
Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice.
Proteomic analysis of the mode of antibacterial action of trans-cinnamaldehyde against Cronobacter sakazakii 415.
Poly (DL-lactide-co-glycolide) (PLGA) nanoparticles with entrapped trans-cinnamaldehyde and eugenol for antimicrobial delivery applications.
Contact and fumigant toxicity of cinnamaldehyde and cinnamic acid and related compounds to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae).
Antifungal activity of α-methyl trans cinnamaldehyde, its ligand and metal complexes: promising growth and ergosterol inhibitors.
Trans-cinnamaldehyde decreases attachment and invasion of uropathogenic Escherichia coli in urinary tract epithelial cells by modulating virulence gene expression.
Effect of trans-cinnamaldehyde on inhibition and inactivation of Cronobacter sakazakii biofilm on abiotic surfaces.
Fumigant toxicity of cassia and cinnamon oils and cinnamaldehyde and structurally related compounds to Dermanyssus gallinae (Acari: Dermanyssidae).
Further antinociceptive effects of myricitrin in chemical models of overt nociception in mice.
Inactivation of Salmonella spp. on tomatoes by plant molecules.
Effect of trans-cinnamaldehyde on reducing resistance to environmental stresses in Cronobacter sakazakii.
Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of site-saturated libraries.
Reduction of Escherichia coli O157:H7 viability on leafy green vegetables by treatment with a bacteriophage mixture and trans-cinnamaldehyde.
Enantioselective synthesis of α-methyl carboxylic acids from readily available starting materials via chemoenzymatic dynamic kinetic resolution.
Composition, antimicrobial activity and in vitro cytotoxicity of essential oil from Cinnamomum zeylanicum Blume (Lauraceae).
Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.
Hydrogenation of Unsaturated Carbonyl Compounds on non-Calcined LDHs. I. Synthesis and Characterization of ZnNiCuAl Hydrotalcite-like Materials.
Enhancing the thermal destruction of Escherichia coli O157:H7 in ground beef patties by trans-cinnamaldehyde.
Effect of subinhibitory concentrations of plant-derived molecules in increasing the sensitivity of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 to antibiotics.
Chemical constituents and antimicrobial activities of Canthium horridum.
Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells.
Fumigant toxicity of essential oils to the German cockroach (Dictyoptera: Blattellidae).
Continuous two-phase flow miniaturised bioreactor for monitoring anaerobic biocatalysis by pentaerythritol tetranitrate reductase.
Antibiofilm effect of trans-cinnamaldehyde on uropathogenic Escherichia coli.
Active paraffin-based paper packaging for extending the shelf life of cherry tomatoes.
Inactivation of Escherichia coli O157:H7 in apple juice and apple cider by trans-cinnamaldehyde.
Topical toxicity of essential oils to the German cockroach (Dictyoptera: Blattellidae).
Constituents of cinnamon inhibit bacterial acetyl CoA carboxylase.
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention.
Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties.
Antityrosinase and antimicrobial activities of trans-cinnamaldehyde thiosemicarbazone.
Effect of selected antimicrobial compounds on the radiosensitization of Salmonella Typhi in ground beef.
Optimization of a phenylacetaldehyde-based attractant for common green lacewings (Chrysoperla carnea s.l.).
Antibacterial effect of plant-derived antimicrobials on major bacterial mastitis pathogens in vitro.
Encapsulation performance of proteins and traditional materials for spray dried flavors.
Toxicity of cassia and cinnamon oil compounds and cinnamaldehyde-related compounds to Sitophilus oryzae (Coleoptera: Curculionidae).
Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress.
Inactivation of Enterobacter sakazakii in reconstituted infant formula by trans-cinnamaldehyde.
HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.
Reduction of Escherichia coli O157:H7 in cattle drinking-water by trans-cinnamaldehyde.
Bis (trans-cinnamaldehyde) ethylene diimine dibromonickel (II) complex as a neutral carrier for salicylate-selective liquid membrane and coated graphite sensors.
Asymmetric synthesis of alpha-amino acids: preparation and alkylation of monocyclic iminolactones derived from alpha-methyl trans-cinnamaldehyde.
Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.
Insecticidal activities of leaf essential oils from Cinnamomum osmophloeum against three mosquito species.
Controllable synthesis of VSB-5 microspheres and microrods: growth mechanism and selective hydrogenation catalysis.
Effect of food characteristics, storage conditions, and electron beam irradiation on active agent release from polyamide-coated LDPE films.
Fumigant toxicity of cassia bark and cassia and cinnamon oil compounds to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae).
Trans-cinnamaldehyde from Cinnamomum zeylanicum bark essential oil reduces the clindamycin resistance of Clostridium difficile in vitro.
Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway.
Supercritical CO2 extract of Cinnamomum zeylanicum: chemical characterization and antityrosinase activity.
Susceptibility and intrinsic tolerance of Pseudomonas aeruginosa to selected plant volatile compounds.
Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs.
Pollinator and herbivore attraction to cucurbita floral volatiles.
Antibacterial properties and major bioactive components of cinnamon stick (Cinnamomum burmannii): activity against foodborne pathogenic bacteria.
A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents.
Diabrotica flight in time and space as monitored with a high capacity trap placed in Zea mays fields of Illinois, USA.
Terminating red imported fire ants using Cinnamomum osmophloeum leaf essential oil.
Nematicidal Activity of Cassia and Cinnamon Oil Compounds and Related Compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae).
Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo.
Gas-chromatographic method for quantifying carvacrol, thymol, terpinen-4-ol, transl anethole, eugenol and trans-cinnamaldehyde in media simulating pig gut conditions.
Antiplatelet and antithrombotic activities of essential oil from wild Ocotea quixos (Lam.) Kosterm. (Lauraceae) calices from Amazonian Ecuador.
Antimicrobial effect of trans-cinnamaldehyde, (-)-perillaldehyde, (-)-citronellal, citral, eugenol and carvacrol on airborne microbes using an airwasher.
Synthesis of the C29-C37 bicyclic ether core of (+)-sorangicin A.
Repellency of Cinnamomum cassia bark compounds and cream containing cassia oil to Aedes aegypti (Diptera: Culicidae) under laboratory and indoor conditions.
Composition of the essential oil of rootstock from Cimicifuga simplex.
Cinnamaldehyde inhibits phenylalanine ammonia-lyase and enzymatic browning of cut lettuce.
Influence of antimicrobial compounds and modified atmosphere packaging on radiation sensitivity of Listeria monocytogenes present in ready-to-use carrots (Daucus carota).
Combined effects of antimicrobial coating, modified atmosphere packaging, and gamma irradiation on Listeria innocua present in ready-to-use carrots (Daucus carota).
Lewis acid mediated reactions of aldehydes with styrene derivatives: synthesis of 1,3-dihalo-1,3-diarylpropanes and 3-chloro-1,3-diarylpropanols.
Ovicidal and adulticidal activities of Cinnamomum zeylanicum bark essential oil compounds and related compounds against Pediculus humanus capitis (Anoplura: Pediculicidae).
In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes.
(R)-Goniothalamin: total syntheses and cytotoxic activity against cancer cell lines.
Formation of secondary organic aerosol by reactive condensation of furandiones, aldehydes, and water vapor onto inorganic aerosol seed particles.
Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia.
The chemical composition of some Lauraceae essential oils and their antifungal activities.
Highly enantioselective michael addition of silyl nitronates to alpha,beta-unsaturated aldehydes catalyzed by designer chiral ammonium bifluorides: efficient access to optically active gamma-nitro aldehydes and their enol silyl ethers.
Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice.
NTP toxicology and carcinogenesis studies of trans-cinnamaldehyde (CAS No. 14371-10-9) in F344/N rats and B6C3F1 mice (feed studies).
Protein binding and metabolism influence the relative skin sensitization potential of cinnamic compounds.
Phosphorylated 1,6-diphenyl-1,3,5-hexatriene.
Simulating secondary organic aerosol activation by condensation of multiple organics on seed particles.
In vitro effect of essential oils from Cinnamomum aromaticum, Citrus limon and Allium sativum on two intestinal flagellates of poultry, Tetratrichomonas gallinarum and Histomonas meleagridis.
Cinnamic compound metabolism in human skin and the role metabolism may play in determining relative sensitisation potency.
Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase.
Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase.
Comparison of adult corn rootworm (Coleoptera: Chrysomelidae) sampling methods.
General Synthesis of Polysubstituted Benzo[b]furans.
Stimulatory effect of trans-cinnamaldehyde on norepinephrine secretion in cultured pheochromocytoma (PC-12) cells.
Selective growth inhibitor toward human intestinal bacteria derived from Pulsatilla cernua root.
Combined effect of antimicrobial coating and gamma irradiation on shelf life extension of pre-cooked shrimp (Penaeus spp.).
Phytochemical constituents of Artemisia stolonifera.
Local anaesthetic activity of monoterpenes and phenylpropanes of essential oils.
High-performance liquid chromatography method for the quantification of non-radiolabelled cinnamic compounds in analytes derived from human skin absorption and metabolism experiments.
Phytochemical constituents of Artemisia japonica ssp. littoricola.
Tandem addition beta-lithiation-alkylation sequence on alpha,beta-unsaturated aldehydes.
Cinnamaldehyde content in foods determined by gas chromatography-mass spectrometry.
Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol.
Insecticidal and fumigant activities of Cinnamomum cassia bark-derived materials against Mechoris ursulus (Coleoptera: attelabidae).
Inhibition of fungal cell wall synthesizing enzymes by trans-cinnamaldehyde.
Stimulatory effect of trans-cinnamaldehyde on noradrenaline secretion in guinea-pig ileum myenteric nerve terminals.
The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides.
Novel substrates of yeast alcohol dehydrogenase-3. 4-dimethylamino-cinnamaldehyde and chloroacetaldehyde.
Selective Oxygen Transfers with Iron(III) Porphyrin Nitrite.
Phenylpropanoids as attractants for adult Stomoxys calcitrans (Diptera:Muscidae).
Studies on trans-cinnamaldehyde II: Mechanisms of cytotoxicity in rat isolated hepatocytes.
Rapid, specific and sensitive method for isoniazid determination in serum.
In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis.
Indole as an olfactory synergist for volatile kairomones for diabroticite beetles.
Studies on trans-cinnamaldehyde. 1. The influence of dose size and sex on its disposition in the rat and mouse.
The effect of food chemicals on cell aging of human diploid cells in in vitro culture.
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.
Inhibition and inactivation of monoamine oxidase by 3-amino-1-phenyl-prop-1-enes.
Evolution of diabroticite rootworm beetle (Chrysomelidae) receptors for Cucurbita blossom volatiles.
Cinnamyl derivatives and monoterpenoids as nonspecific ovipositional deterrents of the onion fly.
Neoplastic transformation of Chinese hamster cells in vitro after treatment with flavoring agents.
Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.
Effects of the antimutagen cinnamaldehyde on reversion and survival of selected Salmonella tester strains.
Isolation of a Highly Sweet Constituent from Cinnamomum osmophloeum Leaves1.
Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program.
High-performance liquid chromatographic-fluorometric determination of cinnamaldehyde in perfume, cologne and toilet water.
A fluorometric assay of trans-cinnamaldehyde in cinnamon.
Geometric specificity of alcohol dehydrogenases and its potential for separation of trans and cis isomers of unsaturated aldehydes.
Inhibition of Aspergillus growth and aflatoxin release by derivatives of benzoic acid.
Mutagenicity of vinyl compounds in Salmonella typhimurium.
Enzymes catalysing conjugations of glutathione with alpha-beta-unsaturated carbonyl compounds.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00903
HMDB (The Human Metabolome Database):HMDB03441
FooDB:FDB008782
Export Tariff Code:2912.29.5000
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
Formulations/Preparations:
•perfume grade, fcc, 98% min purity. •chief ingredient (up to 90%) of oil of cinnamon. •cinnacure a3005; active ingredient 30.00% cinnamaldehyde •cinnacure ready to use; active ingredient 0.255% cinnamaldehyde

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 132.16195678711
Specific gravity @ 20 °C
Pounds per Gallon 8.756 to 8.797
Refractive Index 1.619 to 1.625 @ 20 °C
Vapor Pressure 0.027 mmHg @ 25 °C
Flash Point TCC Value 71.11 °C TCC
logP (o/w) 1.82
Solubility
alcohol Yes
water, 2150 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Spicy
sweet, spicy, candy, cinnamon, warm
General comment At 10.00 % in dipropylene glycol. sweet spice candy cinnamon red hots warm
Flavor Type: Spicy
cinnamon, spicy
General comment Cinnamon spicy

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 21/41 - Harmful in contact with skin, risk of serious damage to eyes.
R 38 - Irritating to skin.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 24 - Avoid contact with skin.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Sensitization
IFRA fragrance material specification:
The concentration of Cinnamic aldehyde in the finished cosmetic product should not exceed 0.1%.
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.02 %
Category 2: Products applied to the axillae
0.02 %
Category 3: Products applied to the face/body using fingertips
0.05 %
Category 4: Products related to fine fragrance
0.05 %
Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.05 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
Category 5D: Baby Creams, baby Oils and baby talc
Category 6: Products with oral and lip exposure
0.40 %
Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
0.40 %
Category 7B: Leave-on products applied to the hair with some hand contact
Category 8: Products with significant anogenital exposure
0.05 %
Category 9: Products with body and hand exposure, primarily rinse off
0.05 %
Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
0.05 %
Category 10B: Household aerosol/spray products
Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
See Note %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

For this material, for pragmatic reasons, restrictive levels allowed by the QRA for certain categories but actually being higher than those already in place before applying the QRA, will temporarily not be implemented until the end of a 5 year monitoring phase. At the end of the 5 years the position will be reevaluated again.

(1) IFRA would recommend that any material used to impart perfume or flavour in products intended for human ingestion should consist of ingredients that are in compliance with appropriate regulations for foods and food flavourings in the countries of planned distribution and, where these are lacking, with the recommendations laid down in the Code of Practice of IOFI (International Organisation of the Flavor Industry). Further information about IOFI can be found on its website (www.iofi.org).

(2) Category 11 includes all non-skin contact or incidental skin contact products. Due to the negligible skin contact from these types of products there is no justification for a restriction of the concentration of this fragrance ingredient in the finished product.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -180.00000
beverages(nonalcoholic): -9.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -4900.00000
condiments / relishes: -20.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -7.70000
fruit ices: -7.70000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -700.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -60.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 214: alpha,beta-Unsaturated aldehydes and precursors from chemical subgroup 3.1 of FGE.19: Cinnamyl derivatives[1]
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :637511
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(E)-3-phenylprop-2-enal
Chemidplus:0014371109
EPA/NOAA CAMEO:hazardous materials
RTECS:GD6476000 for cas# 14371-10-9