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2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide

Chemical Structure

General Material Information

Preferred name 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide
Trivial Name 2-(4-Methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)acetamide
Short Description acetamide, 2-(4-methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)-
Formula C17 H17 N3 O2 S
CAS Number 1374760-95-8
FEMA Number 4809
Flavis Number 16.133
FDA UNII OW22Q34GIJ
Nikkaji Number J3.484.487I
xLogP3-AA 3.20 (est)
NMR Predictor External link
JECFA Food Flavoring 2237 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
Synonyms
  • acetamide, 2-(4-methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)-
  • 2-(4-methyl phenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl) acetamide
  • 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide
  • 2-(4-Methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)acetamide
  • 2-(4-Methylphenoxy)-N-1H-pyrazol-5-yl-N-(2-thienylmethyl)acetamide
  • FEMA 4809
  • N-(1H-Pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide
  • 2-(p-Tolyloxy)-N-(1H-pyrazol-3-yl)-N-[(thien-2-yl)methyl]acetamide
  • Freezestorm

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 327.40689086914
Melting Point 115 to 116.5°C @ 760 mm Hg
Solubility
water, 21.91 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Flavor Type: Cooling
cooling
General comment Cooling

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide usage levels up to:
not for fragrance use.
Threshold of Concern:90 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 27. Update in publication number(s): 28
Click here to view publication 27
average usual ppmaverage maximum ppm
baked goods: 3.0000015.00000
beverages(nonalcoholic): 1.000003.00000
beverages(alcoholic): 2.000006.00000
breakfast cereal: 3.0000015.00000
cheese: --
chewing gum: 75.00000150.00000
condiments / relishes: 3.0000015.00000
confectionery froastings: 5.0000030.00000
egg products: 3.0000015.00000
fats / oils: 3.0000015.00000
fish products: --
frozen dairy: 1.000003.00000
fruit ices: 1.000003.00000
gelatins / puddings: 1.000003.00000
granulated sugar: --
gravies: 3.0000015.00000
hard candy: 5.0000015.00000
imitation dairy: 1.000003.00000
instant coffee / tea: 1.000003.00000
jams / jellies: 1.000003.00000
meat products: 3.0000015.00000
milk products: 1.000003.00000
nut products: 1.000003.00000
other grains: --
poultry: 3.0000015.00000
processed fruits: 1.000003.00000
processed vegetables: 3.0000015.00000
reconstituted vegetables: 3.0000015.00000
seasonings / flavors: 3.0000015.00000
snack foods: 3.0000015.00000
soft candy: 5.0000015.00000
soups: 3.0000015.00000
sugar substitutes: --
sweet sauces: 5.0000015.00000

Safety references

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion of Flavouring Group Evaluation 411 (FGE.411): 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide from chemical group 30 (miscellaneous substances)
View page or View pdf

EPI System: View
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EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :67516108
National Institute of Allergy and Infectious Diseases:Data
2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide
Chemidplus:1374760958