rebaudioside C

General Material Information

Trivial Name	rebaudioside C
Short Description	dulcoside B
Formula	C44 H70 O22
CAS Number	63550-99-2
FEMA Number	4720
FDA UNII	FE0M8Z5L2E
MDL	MFCD02752304
xLogP3-AA	-2.30 (est)
NMR Predictor	External link
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	63550-99-2 ; REBAUDIOSIDE C
Synonyms	1-O-[(5xi,8alpha,9xi,10alpha,13alpha)-13-{[6-deoxy-alpha-D-mannopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranosyl]oxy}-18-oxokaur-16-en-18-yl]-D-glucopyranose dulcoside B rebaudioside C natural RP44

US / EU / FDA / JECFA / FEMA / Scholar / Patents

Google Scholar	Start search
Google Books	Start search
Google Patents	Start search
Perfumer & Flavorists	Start search
EU Patents	Start search
PubMeb	Start search
NCBI	Start search

Literature & References

NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	3085268
Pubchem (sid):	135233038

Publications by Google Patents
Rebaudioside C and Its Stereoisomers as Natural Product Sweetness Enhancers
Methods for using rebaudioside c as a flavor enhancer
High-Purity Rebaudioside C And Process For Purification Of The Same
Publications by US Patents
8,889,841 - Method for purifying rebaudioside C
8,691,879 - Methods for using rebaudioside C as a flavor enhancer
Publications by PubMed
[Biological conversion of stevioside to steviol by Aspergillus aculeatus and the purification of rebaudioside A].
Hydrogenation of the exocyclic olefinic bond at C-16/C-17 position of ent-kaurane diterpene glycosides of Stevia rebaudiana using various catalysts.
Simultaneous analysis of steviol and steviol glycosides by liquid chromatography with ultraviolet detection on a mixed-mode column: application to Stevia plant material and Stevia-containing dietary supplements.
Stevia rebaudiana Bertoni as a source of bioactive compounds: the effect of harvest time, experimental site and crop age on steviol glycoside content and antioxidant properties.
Catalytic Hydrogenation of the Sweet Principles of Stevia rebaudiana, Rebaudioside B, Rebaudioside C, and Rebaudioside D and Sensory Evaluation of Their Reduced Derivatives.
Large-scale profiling of diterpenoid glycosides from Stevia rebaudiana using ultrahigh performance liquid chromatography/tandem mass spectrometry.
Novel CNGA3 and CNGB3 mutations in two Pakistani families with achromatopsia.
Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra-high-performance liquid chromatography-mass spectrometry.
Molecular characterization and phylogenetic analysis of the complete genome of a porcine sapovirus from Chinese swine.
Protective effect and granuloma down-modulation promoted by RP44 antigen a fructose 1,6 bisphosphate aldolase of Schistosoma mansoni.
Monitoring stevioside in soju by high-performance liquid chromatography and liquid chromatography/mass spectrometry.
Seroprevalence of human granulocytic ehrlichiosis infection in Belgium.
Rebaudioside F, a diterpene glycoside from Stevia rebaudiana.
Western blot analysis of sera reactive to human monocytic ehrlichiosis and human granulocytic ehrlichiosis agents.
Comparison of two recombinant major outer membrane proteins of the human granulocytic ehrlichiosis agent for use in an enzyme-linked immunosorbent assay.
Expression of interleukin-1beta, tumor necrosis factor alpha, and interleukin-6 in human peripheral blood leukocytes exposed to human granulocytic ehrlichiosis agent or recombinant major surface protein P44.
Pulsed-field gel electrophoresis is more efficient than ribotyping and random amplified polymorphic DNA analysis in discrimination of Pasteurella haemolytica strains.
Cloning and expression of the 44-kilodalton major outer membrane protein gene of the human granulocytic ehrlichiosis agent and application of the recombinant protein to serodiagnosis.
Publications by Leffingwell & Associates
Flavor Properties of FEMA GRAS List 25 flavor chemicals

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	HMDB34947
FooDB:	FDB013540
Export Tariff Code:	3301.29.6000
FDA Listing of Food Additive Status:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Suppliers

BOC Sciences	Carbosynth
Layn Natural ingredients	Matrix Scientific
Nacalai USA	Penta International
PureCircle	Sigma-Aldrich
Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	951.02429199219
Flash Point TCC Value	310.5 °C TCC
logP (o/w)	-0.851 est
Solubility
alcohol	Yes
water, 12.48 mg/L @ 25 °C (est)	Yes
water	No

Organoleptic Properties

Flavor Type: Sweet
sweet, sugar
General comment	Sweet

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
sweeteners, flavor enhancers
Recommendation for rebaudioside C usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 25. Update in publication number(s): 26
Click here to view publication 25
		average usual ppm	average maximum ppm
baked goods:		100.00000	400.00000
beverages(nonalcoholic):		100.00000	400.00000
beverages(alcoholic):		50.00000	150.00000
breakfast cereal:		200.00000	400.00000
cheese:		-	-
chewing gum:		1000.00000	1000.00000
condiments / relishes:		-	-
confectionery froastings:		100.00000	300.00000
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		100.00000	300.00000
fruit ices:		100.00000	300.00000
gelatins / puddings:		50.00000	300.00000
granulated sugar:		-	-
gravies:		50.00000	100.00000
hard candy:		-	-
imitation dairy:		80.00000	200.00000
instant coffee / tea:		-	-
jams / jellies:		50.00000	300.00000
meat products:		-	-
milk products:		100.00000	400.00000
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		50.00000	100.00000
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

EPI System: View

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :3085268

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

Chemidplus:0063550992