vanilla cresol

Vanilla cresol, also known as 2-ethoxy-4-methylphenol and by its trade name Ultravanil, is an aromatic phenolic compound characterized by the molecular formula C₉H₁₂O₂. This compound presents as a clear fragrance ingredient notable for its medium-strength vanilla odor with sweet, woody, and slightly phenolic notes. It is utilized in aroma formulations for its distinctive vanilla absolute character but possesses a faintly burnt undertone. Vanilla cresol is synthesized or derived through chemical modification of cresol derivatives and is listed under authoritative chemical databases including PubChem, facilitating controlled vocabulary referencing. Its sensory profile and chemistry make it valuable in perfumery as a lasting scent enhancer, especially when combined with other vanillic aroma chemicals.

Vanilla cresol is not typically found as a naturally occurring compound but is produced through organic synthesis for use in fragrance-related applications. It serves as a key functional component in perfuming agents, contributing to amber, heliotrope, moss, oriental, vanilla, and woody aromatic profiles. When employed in formulations, it can enhance the longevity and depth of vanilla notes and works synergistically with vanillin and ethyl vanillin. Compliance with IFRA (Global) standards ensures safe use concentrations in consumer products. Vanilla cresol’s properties make it suitable as a boosting agent in complex perfume compositions and fine fragrance products.

Vanilla cresol exhibits moderate volatility with a boiling point ranging from 243 to 244°C at standard atmospheric pressure, consistent with a molecular structure that supports stability in fragrance blends. It has an estimated log P value of approximately 2.4, indicating moderate hydrophobicity and suitable solubility in alcohols while being only slightly soluble in water. The compound's specific gravity near 1.066 at 25°C supports its integration into liquid formulations. A flash point of 93°C reflects a relatively safe handling profile under typical manufacturing conditions. Its vapor pressure at room temperature is low, which contributes to its substantivity in perfumes, lasting up to several hundred hours when undiluted. Its chemical stability extends to formulations with moderately higher pH levels, allowing it to maintain aroma integrity. These properties influence formulation strategies and application techniques within the fragrance industry.

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Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. R 43 - May cause sensitisation by skin contact. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Acute toxicity, Oral (Category 4), H302 Acute toxicity, dermal (Category 4), H312 Skin irritation (Category 2), H315 Serious eye damage/eye irritation (Category 2A), H320 Acute toxicity, Inhalation (Category 4), H332 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
GHS Label elements, including precautionary statements
Pictogram
Signal word	Warning
Hazard statement(s)
H302 - Harmful if swallowed H312 - Harmful in contact with skin H315 - Causes skin irritation H320 - Causes eye irritation H332 - Harmful if inhaled H335 - May cause respiratory irritation
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P264 - Wash skin thouroughly after handling. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302 + P352 - IF ON SKIN: wash with plenty of soap and water. P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention. P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Dermal sensitization and systemic toxicity
	View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.0087 %
Category 2: Products applied to the axillae
0.0053 %
Category 3: Products applied to the face/body using fingertips
0.017 %
Category 4: Products related to fine fragrance
0.099 %
	Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.025 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.017 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.025 %
Category 5D: Baby Creams, baby Oils and baby talc
0.0058 %
Category 6: Products with oral and lip exposure
0.0087 %
	Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
0.044 %
Category 7B: Leave-on products applied to the hair with some hand contact
0.044 %
Category 8: Products with significant anogenital exposure
0.0058 %
Category 9: Products with body and hand exposure, primarily rinse off
0.052 %
	Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
0.052 %
Category 10B: Household aerosol/spray products
0.052 %
	Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
0.0058 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
0.0058 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
4.20 %
	Notes:
IFRA FLAVOR REQUIREMENTS:
Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.
Recommendation for vanilla cresol flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

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EPA Substance Registry Services (TSCA):2563-07-7

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :75715

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

2-ethoxy-4-methylphenol

Chemidplus:0002563077