rose pyran

Rose pyran, also known by several synonyms including doremol and doremox (Firmenich), is a chemical compound with the molecular formula C₁₂H₁₆O. It belongs to the class of tetrahydro-2H-pyrans, characterized by a saturated six-membered ring containing one oxygen atom. This compound exhibits a medium-strength floral odor with fresh rose, green, herbal, and phenolic notes, contributing complexity and refinement to fragrance blends. It is a notable ingredient for imparting diffusive rosy effects in perfumery. The compound is documented under standardized chemical databases such as PubChem and is typically synthesized or isolated for use as a fragrance agent. Its physical appearance corresponds to a clear, colorless liquid with specific organoleptic and physicochemical properties.

Rose pyran is primarily utilized as a fragrance agent in the cosmetic and personal care industries. It complements various floral blends and is known to combine well with herbal, aromatic, citrus, and fruity notes, enhancing the complexity of scents. The compound is applied widely in perfuming agents including fine fragrances, shampoos, and shower gels. According to IFRA (Global) standards, usage recommendations permit rose pyran concentrations up to 5% in fragrance concentrates. This regulation supports safe incorporation while maintaining desired olfactory characteristics. The compound’s natural biological occurrence is limited, and its application relies on synthetic or semi-synthetic production routes tailored for commercial fragrance formulations.

Rose pyran has an estimated molecular weight of 176.26 and a moderate lipophilicity indicated by a logP value near 3.3, which facilitates its solubility in organic solvents like alcohol. Its specific gravity at 25 °C ranges approximately from 0.98 to 0.99, consistent with a dense liquid. The compound boils between 265 and 266 °C at standard atmospheric pressure (760 mm Hg), evidencing a relatively high boiling point for volatility control in formulations. Vapor pressure measures 0.015 mmHg at 25 °C, indicating low volatility but sufficient diffusion for fragrance release. Rose pyran is soluble in alcohol and marginally soluble in water with an estimated solubility around 61 mg/L at 25 °C. Its flash point is around 93 °C (200 °F), a consideration for handling and safety. Stability data suggest compatibility across multiple product types, including detergents, softeners, and fine fragrances, with usage levels adjusted to maintain odor integrity.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View
Wikipedia:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for rose pyran usage levels up to:
	5.0000 % in the fragrance concentrate.
Recommendation for rose pyran flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :3024003

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

4-methyl-2-phenyloxane

Chemidplus:0094201737