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ortho-salicylic acid
General Material Information
| Preferred name | ortho-salicylic acid |
| Trivial Name | Salicylic acid |
| Short Description | 2-hydroxybenzoic acid |
| Formula | C7 H6 O3 |
| CAS Number | 69-72-7 |
| FEMA Number | 3985 |
| Flavis Number | 8.112 |
| ECHA Number | 200-712-3 |
| FDA UNII | O414PZ4LPZ |
| Nikkaji Number | J2.370A |
| Beilstein Number | 0774890 |
| MDL | MFCD00002439 |
| COE Number | 10165 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 958 2-hydroxybenzoic acid |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 69-72-7 ; SALICYLIC ACID |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| 2-hydroxybenzoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 69-72-7 |
| Pubchem (cid): | 338 |
| Pubchem (sid): | 135269852 |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00805 |
| HMDB (The Human Metabolome Database): | HMDB01895 |
| FooDB: | FDB000882 |
| YMDB (Yeast Metabolome Database): | YMDB01322 |
| Export Tariff Code: | 2918.29.0800 |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: salicylic acid formulations: salicylic acid formulations: preparation dose (%) product manufacturer fostex medicated cleansing bar bristol-myers salicylic acid cleansing bar stiefel cream fostex medicated cleansing cream bristol-myers deep cleansing shower gel glaxosmithkline neutrogena clear pore treatment neutrogena propa ph peel-off acne mask stri-dex clear gel maximum strength (with sd alcohol 9.3%) blistex hydrisalic (with sd alcohol 40b and propylene glycol) pedinol clear away gel (with alcohol 57.6% ww, ether 16.4% ww in flexible collodion) schering-plough compound w gel (with alcohol 57.6% and ether 16.42% in flexible collodion) medtech duoplant gel (with alcohol 67.5% in flexible collodion) schering-plough lotion salac acne medication-cleanser (with benzyl alcohol) bioglan sebasorb (with attapulgite activated 10%) summers ointment mg 217 sal-acid triton plaster trans-ver-sal (with propylene glycol) clear away schering-plough clear away plantar system schering-plough compound w one step pads medtech freezone pads medtech mediplast beiersdorf sal-acid pedinol pledgets (saturated with solution) oxy balance daily cleansing pads (with sd alcohol 40b 40% and propylene glycol) glaxosmithkline stri-dex regular strength pads (with sd alcohol 28%) blistex stri-dex sensitive skin pads (with sd alcohol 28% and aloe) blistex noxzema 2-in-1 pads extra strength procter & gamble oxy balance maximum daily cleansing pads (with sd alcohol 40b 50% and propylene glycol) glaxosmithkline stayclear deep cleaning pads boots stri-dex pads maximum strength (with sd alcohol 40 44%) blistex stri-dex super scrub pads (with sd alcohol 54%) blistex shampoo ionil plus (with sd alcohol 40 12%) healthpoint dhs sal shampoo person & covey neutrogena tsal maximum strength neutrogena solution propa ph cleanser (with sd alcohol 40 25% and aloe) propa ph normalsensitive astringent cleanser sebucare lotion (with alcohol 61%) bristol-myers squibb multi-action astringent (with alcohol 38.8%) glaxosmithkline noxzema 2-in-1 astringent procter & gamble propa ph foaming face wash propa ph maximum strength astringent cleanser stayclear zone-controlled clearstick boots gordofilm (in flexible collodian) gordon clear away liquid (with 17% sd alcohol 32, ether 52% in flexible collodion) schering-plough compound w solution (with alcohol 21.2% and ether 63.5% in flexible collodion) medtech duofilm (with alcohol sd 32 17% and ether 52% in flexible collodion) schering-plough occlusal-hp (with isopropyl alcohol 63% in a polyacrylic vehicle) bioglan off-ezy wart remover (with alcohol 21% and ether 65% in flexible collodion) salactic film (with isopropyl alcohol 2.7% in a flexible collodion) pedinol sal-plant gel (with isopropyl alcohol 2.5% in flexible collodion) pedinol wart-off (with alcohol 26.35% in flexible collodion) pfizer freezone (with alcohol 20.5% and ether 65.5% in flexible collodion) medtech | |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 138.12242126465 |
| Melting Point | 158 to 161°C @ 760 mm Hg |
| Boiling Point | 336 to 337°C @ 760 mm Hg |
| Vapor Pressure | 1 mmHg @ 114 °C |
| Vapor Density | 4.8 |
| Flash Point TCC Value | 100 °C TCC |
| logP (o/w) | 2.26 |
| Solubility | |
| alcohol | Yes |
| water, 3808 mg/L @ 25 °C (est) | Yes |
| water, 2240 mg/L @ 25 °C (exp) | Yes |
Organoleptic Properties
| Odor Type: Nutty | |
| phenolic, nutty | |
| General comment | At 100.00 %. faint phenolic nutty |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Castoreum |
| Other purposes | Antidandruff agents, Bacteriostatic, Fungicide, Hair conditioning, Keratolytics, Preservatives, Skin conditioning |
| Cosmetic purposes | Antidandruff agents, Fragrance, Hair conditioning, Keratolytics, Preservatives, Skin conditioning |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 891 mg/kg BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971 oral-mouse LD50 480 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959. oral-rabbit LD50 1300 mg/kg Drugs in Japan Vol. 6, Pg. 291, 1982. intraperitoneal-rat LD50 157 mg/kg BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992. oral-mouse LD50 908 mg/kg (Sado, 1973) gavage-rat LD50 1050 mg/kg (Hasegawa et al., 1989) oral-cat LD50 400 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959. intraperitoneal-mouse LD50 300 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gendai no Rinsho. Vol. 3, Pg. 675, 1969. intravenous-mouse LD50 184 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 > 10000 mg/kg BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971 skin-rat LD50 > 2000 mg/kg LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl subcutaneous-mouse LD50 520 mg/kg BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: CHANGE IN RATE Archives Internationales de Pharmacodynamie et de Therapie. Vol. 38, Pg. 9, 1930. subcutaneous-rabbit LDLo 6000 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935. skin-man TDLo 57 mg/kg SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR JAMA, Journal of the American Medical Association. Vol. 244, Pg. 660, 1980. | |
| Inhalation Toxicity: | |
| inhalation-rat LC50 > 900 mg/m3/1H BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971 inhalation-mammal (species unspecified) LC50 > 300 mg/m3 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992. | |
Safety in use information
| Category: | |||
| stabilizing agents | |||
| Recommendation for ortho-salicylic acid usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.024 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.03 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 20 | |||
| Click here to view publication 20 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | - | |
| beverages(nonalcoholic): | 5.00000 | 50.00000 | |
| beverages(alcoholic): | 10.00000 | 100.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 10.00000 | 100.00000 | |
| fruit ices: | 10.00000 | 100.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | 10.00000 | 100.00000 | |
| meat products: | - | - | |
| milk products: | 5.00000 | 50.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):69-72-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :338 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WGK Germany:1 |
| 2-hydroxybenzoic acid |
| Chemidplus:0000069727 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:69-72-7 |