acetyl salicylic acid

General Material Information

Preferred name	acetyl salicylic acid
Trivial Name	Aspirin
Short Description	2-acetyloxybenzoic acid
Formula	C9 H8 O4
CAS Number	50-78-2
ECHA Number	200-064-1
FDA UNII	R16CO5Y76E
Nikkaji Number	J2.300K
Beilstein Number	779271
MDL	MFCD00002430
Bio Activity Summary	External link
NMR Predictor	External link
Synonyms	2-acetoxybenzenecarboxylic acid 2-acetoxybenzoic acid 2-acetyloxybenzoic acid 2-( acetyloxy)benzoic acid acesal acesan acetard acetyl salicylic acid USP acimetten asagran ascriptin aspirdrops aspirin aspirin 20-60 mesh USP aspirin 40-80 mesh USP aspirin USP aspropharm benaspir benzoic acid, 2-(acetyloxy)- cardioaspirina claradin clariprin decaten doril easprin globentyl kapsazal melhoral micristin miniasal o- acetylsalicylic acid o-( acetyloxy)benzoic acid ortho-acetyl salicylic acid ortho-acetylsalicylic acid pharmacin polopiryna premaspin rhodine NC RP salcetogen salospir solprin tasprin toldex triaminicin Rhodine Salicylic acid acetate 2-(Acetyloxy)benzoic acid Aceticyl Acetilum acidulatum Acetophen Acetosal Acetosalic acid Acetosalin o-Acetoxybenzoic acid Acetylin Acetylsal Acidum acetylsalicylicum Acylpyrin Aspirine Aspro Asteric A.S.A. Empirin Helicon Measurin Salacetin Saletin Xaxa Acetylsalicylic acid Rhonal Acenterine SP 189 ASA Duramax Ecotrin Entrophen Enterosarine Neuronika Endydol Acetisal Colfarit Acisal Dolean pH 8 AC 5230 o-Carboxyphenyl acetate Triple-sal Rheumintabletten Idragin Yasta Temperal Bialpirina 2-Carboxyphenyl acetate Novid Globoid O-Acetylsalicylic acid Acetysal Medisyl Caprin ECM Empirin Istopirin o-(Acetyloxy)benzoic acid Endosprin Aspro Clear Zorprin Aspirina 03 Aspirin Protect 100 Aspirin Protect 300 Coricidin Contrheuma Retard Aspalon Aspergum Bialpirinia Enterophen Solpyron Darvon Compound Extren Gelprin Nu-seals Supac Acetyonyl Persistin Coricidin D Salycylacetylsalicylic acid Crystar Ascoden 30 Asatard Entericin Albyl E Adiro Ewin Dominal NSC 27223 NSC 406186 Ascolong Aspirin-Direkt Asaflow Trombyl Magnecyl Lysoprin (pharmaceutical) Rhodine 2312 Astrix Mycropyrin Colsprin Ecosprin Cardioaspirin Anopyrin Ecopirin ThromboASS Coraspin Cardiomagnyl Angettes 75 Bayaspirin IWN 11 Rhodine 3118 Rhodine 3220 Zosprin Aspirina Rivo Durlaza Rodine 3220 Rhodine 3040 MeSH ID: D001241

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Literature & References

	2-acetyloxybenzoic acid
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	50-78-2
Pubchem (cid):	2244
Pubchem (sid):	134971785

Publications by Info
Aspirin

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
Golm Metabolome Database:	Search
KEGG (GenomeNet):	C01405
HMDB (The Human Metabolome Database):	HMDB01879
FooDB:	FDB000894
Export Tariff Code:	2918.22.1000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: aspirin formulations: aspirin formulations: preparations dose (mg) product manufacturer pieces, chewing gum aspergum heritage, schering plough tablets aspirin adult low strength geri-care,mango-humphries aspirin low dose basic viatamins norwich aspirin chattem 325 with buffers magnaprin, improved rugby 325 with buffers magnaprin arthritis strength rugby norwich aspirin maximum strength chattem norwich aspirin maximum strength chattem tablets, chewable bayer children's chewable aspirin bayer aspirin childrens amerisourcebergen, cardinal health, chain drug marketing, eckerd, ivax, major, pdk, prime marketing, qualitest, rugby, url aspirin for children geri-care st. joseph aspirin low strength chewable mcneil tablets, delayed-release (enteric-coated) aspirin adult low strength amerisourcebergen aspirin adult low strength aspirin enteric coated advance aspirin low dose qualitest aspirin regimen aspirin regimen low strength cardinal health bayer aspirin regimen adult low strength bayer ecotrin adult low strength (with propylene glycol) glaxosmithkline ecotrin adult low strength (with propylene glycol) glaxosmithkline st. joseph adult low strength enteric coated tablets mcneil 81 with buffers ascriptin enteric regular strength novartis halfprin kramer aspirin for arthritis cardinal health bayer aspirin regimen regular strength caplets (with propylene glycol bayer ecotrin regular strength (with propylene glycol) glaxosmithkline genacote 325 with buffers ascriptin enteric regular strength novartis aspirin extra strength medicine shoppe aspirin maximum strength chain drug marketing ecotrin maximum strength (with propylene glycol) glaxosmithkline aspirin delayed release tablets time-cap, united research easprin harvest tablets, extended-release zorprin tablets, film-coated 81 with buffers women's aspirin plus calcium caplets (with calcium carbonate and crospovidone) bayer aspirin lite coated amerisourcebergen aspirin microthin coating cardinal health bayer aspirin caplets bayer genuine bayer aspirin tablets bayer 325 with buffers ascriptin regular strength novartis 325 with buffers ascriptin arthritis pain caplets novartis 325 with buffers bufferin tablets (with povidone and propylene glycol), novartis consumer health bayer aspirin extra strength caplets (with propylene glycol) bayer bayer aspirin extra strength gelcaplets (with parabens) bayer bayer aspirin extra strength tablets bayer 500 with buffers ascriptin maximum strength caplets novartis 500 with buffers bayer aspirin plus buffered extra strength caplets (with calcium carbonate and propylene glycol) bayer 500 with buffers bufferin arthritis strength caplets (with povidone and propylene glycol) bristol-myers 500 with buffers bufferin extra strength (with povidone and propylene glycol) novartis consumer health tablets, for solution alka-seltzer effervescent pain reliever and antacid (with citric acid 1 g and sodium bicarbonate 1.916 g) bayer alka-seltzer lemon-lime effervescent pain reliever and antacid (with aspartame citric acid 1 g and sodium bicarbonate 1.7 g) bayer alka-seltzer extra strength effervescent pain reliever and antacid (with citric acid 1 g and sodium bicarbonate 1.985 g) bayer rectal suppositories aspirin suppositories consolidated midland aspirin suppositories consolidated midland aspirin suppositories consolidated midland aspirin suppositories consolidated midland, paddock aspirin suppositories consolidated midland, paddock

Suppliers

Alfa Biotechnology	BOC Sciences
ECSA Chemicals	Glentham Life Sciences
Penta International	Sigma-Aldrich: Sigma
Glentham Life Sciences Ltd	Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	180.15956115723
Vapor Pressure	2.5E-5 mmHg @ 25 °C
Flash Point TCC Value	131.2 °C TCC
logP (o/w)	1.19
Solubility
water, 5295 mg/L @ 25 °C (est)	Yes
water, 4600 mg/L @ 25 °C (exp)	Yes

Occurrences

Safety Information

Safety information

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-child LDLo 104 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 2, Pg. 809, 1952. oral-child TDLo 10 mg/kg/1D-I LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Clinical Toxicology. Vol. 18, Pg. 247, 1981. oral-child TDLo 39 mg/kg/13D-I LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" American Journal of Diseases of Children. Vol. 139, Pg. 453, 1985. intravenous-dog LD50 681 mg/kg BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. oral-dog LD50 700 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971. oral-guinea pig LD50 1075 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. oral-hamster LD50 3500 mg/kg Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. oral-human TDLo 480 mg/kg/7D-I BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 281, 1975. oral-human TDLo 669 mg/kg/11D LIVER: LIVER FUNCTION TESTS IMPAIRED American Journal of Hospital Pharmacy. Vol. 35, Pg. 330, 1978. oral-human TDLo 1050 mg/kg/14D VASCULAR: OTHER CHANGES Clinical Pharmacology and Therapeutics Vol. 67, Pg. 530, 2000. oral-human TDLo 2880 mg/kg/8W SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 631, 1983. oral-mammal (species unspecified) LD50 1750 mg/kg Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985. unreported-man LDLo 294 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man TDLo 857 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA Human Toxicology. Vol. 7, Pg. 161, 1988. oral-man TDLo 1625 mg/kg BEHAVIORAL: COMA Clinical Pediatrics Vol. 24, Pg. 678, 1985. oral-man TDLo 13036 mg/kg/5Y SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: OTHER CHANGES MUSCULOSKELETAL: JOINTS Annals of Internal Medicine. Vol. 126, Pg. 665, 1997. intraperitoneal-mouse LD50 167 mg/kg United States Patent Document. Vol. #4376771 oral-mouse LD50 250 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. unreported-mouse LD50 1350 mg/kg United States Patent Document. Vol. #5240918 oral-rabbit LD50 1010 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 43, 1980. intraperitoneal-rat LD50 340 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62, Pg. 11, 1966. oral-rat LD50 200 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969.
Dermal Toxicity:
subcutaneous-mouse LD50 1020 mg/kg Chemical and Pharmaceutical Bulletin. Vol. 28, Pg. 1237, 1980.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
pharmaceuticals / chemical synthisis
Recommendation for acetyl salicylic acid usage levels up to:
	not for fragrance use.

Recommendation for acetyl salicylic acid flavor usage levels up to:
	not for flavor use.