cedrol methyl ether

Cedrol methyl ether is a bicyclic sesquiterpene ether with the molecular formula C₁₆H₂₈O. This compound is also known by the trade name cedramber (IFF) and several synonyms reflecting its stereochemistry. It appears as a clear liquid with notable odor characteristics of dry woody cedar and a rich ambergris-like amber note. The scent is medium in strength with remarkable substantivity, maintaining presence for over five days at full concentration. Cedrol methyl ether is typically derived through synthetic transformation of sesquiterpenoid precursors sourced from essential oils of cedars or analogous botanicals. For detailed chemical information, see its PubChem entry. It is widely used as a fragrance ingredient due to its warm, woody character and its role in deepening amber accords.

Cedrol methyl ether occurs primarily as a synthetic fragrance ingredient inspired by the natural sesquiterpene cedrol, which occurs in certain cedarwood oils. It finds application extensively in perfumery as a woody amber fixative, providing a persistent dry cedar note and an animalic ambergris nuance. Its synergy with other amber ingredients such as methyl cedryl ketone (MCK) and Ambrofix enhances complexity and longevity in fragrance compositions. It is commonly employed in blends mimicking ambergris, patchouli, and leather accords, often in luxury perfumes. According to IFRA (Global) standards, cedrol methyl ether is recommended for fragrance use up to 2.0% concentration in concentrates. It is not authorized for flavoring purposes but may occasionally be used to emulate guaiacwood notes in aromatic applications. Its uses span fine fragrances, functional perfumery, and complex fantasy blends.

Cedrol methyl ether exhibits a relatively high molecular weight of 236.4 g/mol and considerable lipophilicity with an estimated logP of 6.1, indicating its strong affinity for lipid phases in formulations. The compound is a clear liquid at room temperature with a boiling point ranging from 268 to 269 °C at atmospheric pressure, reflecting its moderate volatility suitable for prolonged scent diffusion. It has a specific gravity near 0.975 at 25 °C and a refractive index between 1.494 and 1.498 at 20 °C. Its vapor pressure is low (0.013 mmHg at 25 °C), consistent with its high substantivity on skin and substrate. The flash point is measured at 212 °F (approximately 100 °C), denoting moderate flammability precautions. Cedrol methyl ether is soluble in alcohol and slightly soluble in water (~1.4 mg/L). Stability data indicate compatibility with various product types including soaps, detergents, and shampoos when stored in cool, dry conditions away from heat and light.

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Safety information

European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for cedrol methyl ether usage levels up to:
	2.0000 % in the fragrance concentrate.
Recommendation for cedrol methyl ether flavor usage levels up to:
	not for flavor use.

Safety references

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EPA Substance Registry Services (TSCA):19870-74-7

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Laboratory Chemical Safety Summary :88288

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

Chemidplus:0019870747