(E)-cinnamyl isovalerate

(E)-cinnamyl isovalerate is a synthetic organic ester classified under the chemical formula C14H18O2 and has a molecular weight of approximately 218.3. It appears as a clear, colorless liquid with notable sensory properties characterized by medium intensity spicy odor combined with sweet nuances reminiscent of melon, cherry, green apple, and blueberry. The compound is also recognized for its fruity flavor profile featuring notes of pineapple, cherry, melon, and other fruit accords. Synonyms include butanoic acid, 3-methyl-, (2E)-3-phenyl-2-propen-1-yl ester, and trans-cinnamyl isovalerate. The ester is referenced in authoritative chemical databases such as PubChem. It is typically synthesized for use in flavor and fragrance formulations rather than sourced directly from natural extracts.

(E)-cinnamyl isovalerate is not commonly found as a natural metabolite but is synthesized for application primarily as a flavor and fragrance agent. It is used to impart complex fruity and spicy characteristics to formulations aimed at simulating or enhancing aromas such as apple, apricot, blueberry, cherry, grape, maple, melon, peach, pear, pineapple, plum, rose, rose tea rose, spice, and strawberry notes. Additionally, its flavor properties are exploited in products resembling bread, pepper (including Tabasco-style pepper), and walnut. The compound is regulated under standards such as FEMA (US), which supports its use within prescribed safety limits in flavor and fragrance products.

(E)-cinnamyl isovalerate exhibits a moderate molecular weight and displays physical properties significant for its formulation roles. It is a liquid with a specific gravity close to 0.991 to 0.996 at 25°C and a refractive index ranging from 1.518 to 1.524 at 20°C. The boiling point occurs between 313 and 315°C at standard atmospheric pressure, indicating relative thermal stability. The flash point is approximately 230°F (about 110°C), classifying it as combustible but manageable under typical handling conditions. It has an estimated logP value of 4.013, indicating a lipophilic character contributing to its solubility in alcohol and fixed oils, while water solubility remains very low. At 25°C, vapor pressure is very low (0.00026 mmHg), supporting long substantivity in fragrance applications. Solubility profiles reflect compatibility with alcohol and fixed oils but poor solubility in water, propylene glycol, and glycerin. The acid value is controlled below 3 KOH/g to ensure chemical stability and purity.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2915.60.0000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for (E)-cinnamyl isovalerate usage levels up to:
	8.0000 % in the fragrance concentrate.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :5355855

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

[(E)-3-phenylprop-2-enyl] 3-methylbutanoate

Chemidplus:0000140272

RTECS:EK7902515 for cas# 69121-78-4