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dimethyl sulfoxide

General Material Information

Preferred name	dimethyl sulfoxide
Trivial Name	Dimethyl sulfoxide
Short Description	methyl sulfoxide
Formula	C2 H6 O S
CAS Number	67-68-5
FEMA Number	3875
Flavis Number	12.175
ECHA Number	200-664-3
FDA UNII	YOW8V9698H
Nikkaji Number	J1.933J
Beilstein Number	0506008
MDL	MFCD00002089
xLogP3-AA	-0.60 (est)
Bio Activity Summary	External link
NMR Predictor	External link
JECFA Food Flavoring	507 methylsulfinylmethane
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	67-68-5 ; DIMETHYL SULFOXIDE
Synonyms	demsodrox dermasorb dimethyl sulfoxide USP grade dimethyl sulphoxide dimethyl-sulfoxide dimethyli sulfoxidum dimethylsulfoniumolate dimethylsulfoxide DMSO dolicur dromisol hyadur methane, 1,1'-sulfinylbis- ( methanesulfinyl)methane methyl sulfinyl methane methyl sulfoxide ( methylsulfinyl)methane methylsulfinylmethane rimso 50 sclerosol somipront sulfinyl bis(methane) sulfinylbismethane sulfinyldimethane sulfoxide, dimethyl sulphoxide, dimethyl syntexan topsym Methane, 1,1′-sulfinylbis- Methane, sulfinylbis- 1,1′-Sulfinylbis[methane] SQ 9453 Dimexide DMS 70 DMS 90 Infiltrina Dipirartril-tropico Durasorb Dimexidum Gamasol 90 Kemsol Domoso Demavet Herpid Demeso NSC 763 Demasorb DMSO Evol MeSH ID: D004121

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Literature & References

	methylsulfinylmethane
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	67-68-5
Pubchem (cid):	679
Pubchem (sid):	134970726
Flavornet:	67-68-5
Pherobase:	View

Publications by Info
Dimethylsulfoxide (DMSO)
Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.)
Publications by PubMed
Non-animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties.
Effect of sodium chloride on efficiency of cisplatinum dissolved in dimethyl sulfoxide: an in vitro study.
Effects of nuclear receptor transactivation on boar taint metabolism and gene expression in porcine hepatocytes.
Effect of type of oil and addition of delta-tocopherol on model flavor compound stability during storage.
The level of MXR1 gene expression in brewing yeast during beer fermentation is a major determinant for the concentration of dimethyl sulfide in beer.
Influence of some technological parameters on the formation of dimethyl sulfide, 2-mercaptoethanol, methionol, and dimethyl sulfone in port wines.
Characterization of odorant compounds of mussels (Mytilus edulis) according to their origin using gas chromatography-olfactometry and gas chromatography-mass spectrometry.
A comparison of the mutagenicity of mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (K1R4F).
Comparative genotoxicity testing of mainstream whole smoke from cigarettes which burn or heat tobacco.
Developmental toxicity assay using high content screening of zebrafish embryos.
5-Amino-6-benzoyl-8-nitro-2,3-di-hydro-1H-spiro-[imidazo[1,2-a]pyridine-7,3'-indolin]-2'-one dimethyl sulfoxide monosolvate.
A novel method for the rapid detection of benzo(a)pyrene in liquid milk by dimethyl sulfoxide selectively enhanced synchronous fluorescence spectrometry.
Per-O-acetylation of cellulose in dimethyl sulfoxide with catalyzed transesterification.
Validation and application of an improved method for the rapid determination of proline in grape berries.
Limitations of waterborne exposure of fish early life stages to BDE-47.
Improving size-exclusion chromatography separation for glycogen.
Improved stability of trans-resveratrol in aqueous solutions by carboxymethylated (1,3/1,6)-β-D-glucan.
Bis[μ-N-(pyridin-2-ylmeth-yl)pyridin-3-amine-κ(2) N:N']disilver(I) bis-(perchlorate) dimethyl sulfoxide disolvate.
Dual-Component System Dimethyl Sulfoxide/LiCl as a Solvent and Catalyst for Homogeneous Ring-Opening Grafted Polymerization of ε-Caprolactone onto Xylan.
Synthesis, Characterization, and Antimicrobial Activity of Kojic Acid Grafted Chitosan Oligosaccharide.
Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells.
Organic synthesis of maize starch-based polymer using Rhizopus oryzae lipase, scale up, and its characterization.
Synthesis, Characterization, and Bioactivity of Schiff Bases and Their Cd(2+), Zn(2+), Cu(2+), and Ni(2+) Complexes Derived from Chloroacetophenone Isomers with S-Benzyldithiocarbazate and the X-Ray Crystal Structure of S-Benzyl- β -N-(4-chlorophenyl)methylenedithiocarbazate.
Dietary safety of cycloastragenol from Astragalus spp.: subchronic toxicity and genotoxicity studies.
Extraction, isolation and characterisation of phytoglycogen from su-1 maize leaves and grain.
Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice.
Challenges in analysis of high-molar mass dextrans: comparison of HPSEC, AsFlFFF and DOSY NMR spectroscopy.
An approach for prominent enhancement of the quality of konjac flour: dimethyl sulfoxide as medium.
Effect of Cytochalasin B, Lantrunculin B, Colchicine, Cycloheximid, Dimethyl Sulfoxide and Ion Channel Inhibitors on Biospeckle Activity in Apple Tissue.
Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms.
Kinetic study of aroxyl radical scavenging and α-tocopheroxyl regeneration rates of pyrroloquinolinequinol (PQQH2, a reduced form of pyrroloquinolinequinone) in dimethyl sulfoxide solution: finding of synergistic effect on the reaction rate due to the coexistence of α-tocopherol and PQQH2.
Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway.
DHA sensitizes FaO cells to tert-BHP-induced oxidative effects. Protective role of EGCG.
Chemical state of heterocyclic aromatic amines in grilled beef: evaluation by in vitro digestion model and comparison of alkaline hydrolysis and organic solvent for extraction.
Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro.
Preparation of reference stocks suitable for evaluation of alternative NAT-based mycoplasma detection methods.
Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cells.
T-2 toxin is hydroxylated by chicken CYP3A37.
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis.
Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin--modulation by Nrf2.
New inhibitors of nitric oxide production from the seeds of Myristica fragrans.
Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling.
Combined effects of fungal alkaloids on intestinal motility in an in vitro rat model.
Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation.
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.
Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells.
Matrix-derived combination effect and risk assessment for estragole from basil-containing plant food supplements (PFS).
Inhibitory kinetics of chlorocinnamic acids on mushroom tyrosinase.
Inhibitory activities of some vitamins on the formation of cholesterol oxidation products in beef patties.
New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line.
Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.
Absorption of resveratrol by vascular endothelial cells through passive diffusion and an SGLT1-mediated pathway.
Czech ethanol-free propolis extract displays inhibitory activity against a broad spectrum of bacterial and fungal pathogens.
Intestinal absorption of lysozyme, an egg-white allergen, in rats: kinetics and effect of NSAIDs.
Currently used pesticides and their mixtures affect the function of sex hormone receptors and aromatase enzyme activity.
Buckwheat trypsin inhibitor enters Hep G2 cells by clathrin-dependent endocytosis.
Solvent effects and improvements in the deoxyribose degradation assay for hydroxyl radical-scavenging.
Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice.
Immunostimulatory activity of polysaccharides from Cheonggukjang.
Oral administration of chitin and chitosan prevents peanut-induced anaphylaxis in a murine food allergy model.
Activation of the PI3K-AKT-mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation.
Proteomic-based identification of multiple pathways underlying n-butylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells.
Synthesis and characterization of dextrin monosuccinate.
Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats.
Promising properties of a formate dehydrogenase from a methanol-assimilating yeast Ogataea parapolymorpha DL-1 in His-tagged form.
High-throughput screening of a collection of known pharmacologically active small compounds for identification of Candida albicans biofilm inhibitors.
Impact of food to microorganism (F/M) ratio and colloidal chemical oxygen demand on nitrification performance of a full-scale membrane bioreactor treating thin film transistor liquid crystal display wastewater.
Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JC.
Quercetin and epigallocatechin-3-gallate effect on the anisotropy of model membranes with cholesterol.
Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice.
Opposing--activating or inhibitory--effects of cimetidine and daidzein on human ADH1C activity depending on substrates and solvents.
The effect of nonylphenol on the motility and viability of bovine spermatozoa in vitro.
Rapid synthesis of cellulose esters by transesterification of cellulose with vinyl esters under the catalysis of NaOH or KOH in DMSO.
[Simultaneous extraction and determination of nine chemically synthetic anticoccidial drug multi-residues in chicken meat using high performance liquid chromatography-tandem mass spectrometry].
A low molecular mass cutinase of Thielavia terrestris efficiently hydrolyzes poly(esters).
The selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions.
Triflumizole is an obesogen in mice that acts through peroxisome proliferator activated receptor gamma (PPARγ).
Effect of ionic liquid pretreatment on the structure of hemicelluloses from corncob.
Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test.
Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model.
An improved high-throughput Nile red fluorescence assay for estimating intracellular lipids in a variety of yeast species.
Characterization and solvent engineering of wheat β-amylase for enhancing its activity and stability.
Convenient and efficient approach to the permanent or reversible conjugation of RNA and DNA sequences with functional groups.
Vitrification of immature bovine cumulus-oocyte complexes: effects of cryoprotectants, the vitrification procedure and warming time on cleavage and embryo development.
Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine.
Solvent selection and optimization of α-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Tyr-NH2 using mixture design and response surface methodology.
The cryoprotectant used, its concentration, and the equilibration time are critical for the successful cryopreservation of rabbit sperm: DIMETHylacetamide versus dimethylsulfoxide.
Erythrocyte membranes convert monomeric ferriprotoporphyrin IX to β-hematin in acidic environment at malarial fever temperature.
A novel and efficient colorimetric chemosensor for detection and determination of biologically important ions in DMSO/H2O media using bromo pyrogallol red chemosensors with analytical applications.
Ionic liquids as solvents for dissolution of corn starch and homogeneous synthesis of fatty-acid starch esters without catalysts.
Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia.
Supramolecular polymeric chemosensor for biomedical applications: design and synthesis of a luminescent zinc metallopolymer as a chemosensor for adenine detection.
Application of molecularly imprinted hydrogel for the preparation of lactose-free milk.
A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers.
Protection of L-methionine against H₂O₂-induced oxidative damage in mitochondria.
Role of ErbB2 mediated AKT and MAPK pathway in gall bladder cell proliferation induced by argemone oil and butter yellow. Argemone oil and butter yellow induced gall bladder cell proliferation.
Effect of daidzein-low-calorie diet on body weight, serum levels of glucose, resistin, and high sensitive C-reactive protein in high fat, high calorie diet induced rats.
Evaluation of the cytotoxicity of cigarette smoke condensate by a cellular impedance biosensor.
Differential modifying effects of food additive butylated hydroxytoluene toward radiation and 4-nitro-quinoline 1-oxide-induced genotoxicity in yeast.
Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells.
Protective effect of Ginkgo biloba L. leaf extract against glyphosate toxicity in Swiss albino mice.
A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.
New (1)h NMR procedure for the characterization of native and modified food-grade starches.
An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Design and characterization of protein-quercetin bioactive nanoparticles.
Interstitial cystitis/painful bladder syndrome.
Heteronuclear single-quantum coherence nuclear magnetic resonance (HSQC NMR) characterization of acetylated fir (Abies sachallnensis MAST) wood regenerated from ionic liquid.
The effects of commercially available preservative-free FDA-approved triamcinolone (Triesence®) on retinal cells in culture.
Genipa americana (Rubiaceae) fruit extract affects mitogen-activated protein kinase cell pathways in human trophoblast-derived BeWo cells: implications for placental development.
Adsorption behavior of the catechins and caffeine onto polyvinylpolypyrrolidone.
New water resistant biomaterial biocide film based on guar gum.
Novel determination of the total phenolic content in crude plant extracts by the use of 1H NMR of the -OH spectral region.
Curdlan complexes as a potential food-grade delivery system: genistein case study.
Five pseudopolymorphs and a cocrystal of nitrofurantoin.
High-throughput cryopreservation of spermatozoa of blue catfish (Ictalurus furcatus): Establishment of an approach for commercial-scale processing.
Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening.
[Mechanism of interaction between risperidone and tea catechin(1)complex formation of risperidone with epigallocatechin gallate].
Antidiabetic effect of essential oil from Artemisia sieberi growing in Jordan in normal and alloxan induced diabetic rats.
Photochemical and phototoxic properties of ethyl 1,4-dihydro-8-nitro-4-oxoquinoline-3-carboxylate, a new quinoline derivative.
Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway.
Identification of a New Natural Vasorelaxatant Compound, (+)-Osbeckic Acid, from Rutin-free Tartary Buckwheat Extract.
Modification of pineapple peel fiber as metal ion adsorbent through reaction with succinic anhydride in pyridine and dimethyl sulfoxide solvents.
Effects of organic solvents on the reverse transcription reaction catalyzed by reverse transcriptases from avian myeloblastosis virus and Moloney murine leukemia virus.
Determination of melamine and cyanuric acid in powdered milk using injection-port derivatization and gas chromatography-tandem mass spectrometry with furan chemical ionization.
Separation and purification of xylose oligomers using centrifugal partition chromatography.
Effect of intraperitoneal injection of curcumin on food intake in a goldfish model.
Assessment of the genotoxicity of three cryoprotectants used for human oocyte vitrification: dimethyl sulfoxide, ethylene glycol and propylene glycol.
Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience.
[Expression and characterization of lipase LpsA2 from Streptomyces avermitilis].
Microbial inhibitory and radical scavenging activities of cold-pressed terpeneless Valencia orange (Citrus sinensis) oil in different dispersing agents.
Isolation of cellulolytic enzyme lignin from wood preswollen/dissolved in dimethyl sulfoxide/n-methylimidazole.
Volume reduction of nonaqueous media contaminated with a highly halogenated model compound using superoxide.
Anti-mutagenic lichen extract has double-edged effect on azoxymethane-induced colorectal oncogenesis in C57BL/6J mice.
Saccharomyces cerevisiae and Candida albicans stimulate cytokine secretion from human neutrophil-like HL-60 cells differentiated with retinoic acid or dimethylsulfoxide.
Changes of headspace volatiles in milk with riboflavin photosensitization.
An exploratory NMR nutri-metabonomic investigation reveals dimethyl sulfone as a dietary biomarker for onion intake.
Quantitation of S-methylmethionine in raw vegetables and green malt by a stable isotope dilution assay using LC-MS/MS: comparison with dimethyl sulfide formation after heat treatment.
Isolation, cloning and characterization of a tyrosinase with improved activity in organic solvents from Bacillus megaterium.
Characterization of starch by size-exclusion chromatography: the limitations imposed by shear scission.
Sequential injection fluorimetric determination of Sn in juices of canned fruits.
Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide.
A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.
Dissolution of beech and spruce milled woods in LiCl/DMSO.
Cell viability of normal human skin fibroblast and fibroblasts derived from granulation tissue: effects of nutraceuticals.
The roles of actin cytoskeleton and microtubules for membrane recycling of a food vacuole in Tetrahymena thermophila.
Octadecylsilyl silica column method for extraction of messenger RNA.
Identification of free radical intermediates in oxidized wine using electron paramagnetic resonance spin trapping.
Thermal generation of stable SO4*- spin trap adducts with super-hyperfine structure in their EPR spectra: an alternative EPR spin trapping assay for radical scavenging capacity determination in dimethylsulphoxide.
High-molar-mass hyaluronan behavior during testing its radical scavenging capacity in organic and aqueous media: effects of the presence of manganese(II) ions.
Proposed mechanism of inactivating Escherichia coli O157:H7 by ultra-high pressure in combination with tert-butylhydroquinone.
Preoperative embolization of cerebral arteriovenous malformations with onyx.
Assessment of the extent of starch dissolution in dimethyl sulfoxide by 1H NMR spectroscopy.
The effects of boric acid on sister chromatid exchanges and chromosome aberrations in cultured human lymphocytes.
Changes in toxicity and Ah receptor agonist activity of suspended particulate matter during flood events at the rivers Neckar and Rhine - a mass balance approach using in vitro methods and chemical analysis.
Suitability of cryoprotectants and impregnation protocols for embryos of Japanese whiting Sillago japonica.
Inactivation of barotolerant strains of Listeria monocytogenes and Escherichia coli O157:H7 by ultra high pressure and tert-butylhydroquinone combination.
Bioassay directed identification of natural aryl hydrocarbon-receptor agonists in marmalade.
A novel pretreatment approach for fast determination of organochlorine pesticides in biotic samples.
Production of cercosporin toxin by the phytopathogenic Cercospora fungi is affected by diverse environmental signals.
Cryopreservation of human limbal stem cells ex vivo expanded on amniotic membrane.
The effects of food protector biphenyl on sister chromatid exchange, chromosome aberrations, and micronucleus in human lymphocytes.
Role of Campylobacter jejuni respiratory oxidases and reductases in host colonization.
Dose formulation and analysis of diapocynin.
[Changes in H2O2 and salicylic acid contents as well as plasma membrane H+-ATPase activity and their relations in pea leaves during thermotolerance induction].
Effect of type of oil and addition of delta-tocopherol on model flavor compound stability during storage.
A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice.
Colorimetric determination of pure Mg(2+)-dependent phosphatidate phosphatase activity.
Interstitial cystitis/painful bladder syndrome.
Chicken nucleated blood cells as a cellular model for genotoxicity testing using the comet assay.
Inhibitory effect of dimethyl sulfoxide (DMSO) on necrosis and oxidative stress caused by D-galactosamine in the rat liver.
Quantitative analysis of cotton (Gossypium hirsutum) lint trash by fluorescence spectroscopy.
Effect of dimethyl sulphoxide on oxidative stress, activation of mitogen activated protein kinase and necrosis caused by thioacetamide in the rat liver.
Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats.
Oral developmental toxicity study of methylsulfonylmethane in rats.
Methylsulfonylmethane (MSM) ingestion causes a significant resonance in proton magnetic resonance spectra of brain and cerebrospinal fluid.
Construction of a dimethyl sulfoxide sensor based on dimethyl sulfoxide reductase immobilized on a au film electrode.
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.
Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats.
Alkamide stability in Echinacea purpurea extracts with and without phenolic acids in dry films and in solution.
Pro-oxidant activity of oleuropein determined in vitro by electron spin resonance spin-trapping methodology.
Rational design of aziridine-containing cysteine protease inhibitors with improved potency: studies on inhibition mechanism.
An accurate and reproducible method for the quantitative analysis of isoflavones and their metabolites in rat plasma using liquid chromatography/mass spectrometry combined with photodiode array detection.
Iron chelation by the powerful antioxidant flavonoid quercetin.
Quantification of trace volatile sulfur compounds in milk by solid-phase microextraction and gas chromatography-pulsed flame photometric detection.
Helically chiral ferrocene peptides containing 1'-aminoferrocene-1-carboxylic acid subunits as turn inducers.
Antihyperlipidemic and antidiabetic effects of umbelliferone in streptozotocin diabetic rats.
Perinatal asphyxia syndrome in a quarter horse foal.
Left otitis media/interna and right maxillary sinusitis in a Percheron mare.
Antimutagenic activity of Sesbania javanica Miq. flower DMSO extract and its major flavonoid glycoside.
Rice starch, amylopectin, and amylose: molecular weight and solubility in dimethyl sulfoxide-based solvents.
Radioprotective-antimutagenic effects of rosemary phenolics against chromosomal damage induced in human lymphocytes by gamma-rays.
Effect of 17beta-oestradiol on transepithelial calcium transport in human intestinal-like Caco-2 cells and its interactions with 1,25-dihydroxycholecalciferol and 9-cis retinoic acid.
Rapid high-throughput assessment of aerobic bacteria in complex samples by fluorescence-based oxygen respirometry.
Production, properties and application to biocatalysis of a novel extracellular alkaline phenol oxidase from the thermophilic fungus Scytalidium thermophilum.
NMDA receptors mediate feeding elicited by neuropeptide Y in the lateral and perifornical hypothalamus.
Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats.
Safety assessment of food-contact paper and board using a battery of short-term toxicity tests: European union BIOSAFEPAPER project.
Functional barriers: properties and evaluation.
Chemical composition and structural features of the macromolecular components of plantation Acacia mangium wood.
Stable polymeric microballoons as multifunctional device for biomedical uses: synthesis and characterization.
Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Reactive oxygen species produced upon photoexcitation of sunscreens containing titanium dioxide (an EPR study).
Ability of possible DMS precursors to release DMS during wine aging and in the conditions of heat-alkaline treatment.
Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation.
Dietary exposure to Aroclor 1254 alters gene expression in Xenopus laevis frogs.
Extraction and characterization of original lignin and hemicelluloses from wheat straw.
Acrylonitrile-induced toxicity and oxidative stress in isolated rat colonocytes.
Utilization of amylose-lipid complexes as molecular nanocapsules for conjugated linoleic Acid.
Direct detection of bacterial pathogens in representative dairy products using a combined bacterial concentration-PCR approach.
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells.
Inhibitory effects of lignans on the activity of human matrix metalloproteinase 7 (matrilysin).
Effects of substrate pretreatment and water activity on lipase-catalyzed cellulose acetylation in organic media.
Concise preparation of the (3E,5Z)-alkadienyl system. New approach to the synthesis of principal insect sex pheromone constituents.
An in vitro study on antimicrobial activity of propolis from Mugla province of Turkey.
Gastric oxidative stress and hemorrhagic ulcer in Salmonella typhimurium-infected rats.
Multimodal therapy for interstitial cystitis.
NMR regulatory analysis: determination and characterization of Chinese-herb aristolochic acids.
Characterization of potato leaf starch.
Effect of dimethyl sulfoxide in the treatment of sheep experimentally infected with Ehrlichia ruminantium.
Lipase-catalyzed cellulose acetylation in aqueous and organic media.
Vitamin C protects against in vitro cytotoxicity of cypermethrin in rat hepatocytes.
Reversible and irreversible emission of methanethiol and dimethyl disulfide from anaerobically stored broccoli.
Effects of fluoride on Xenopus embryo development.
Polar organic solvent added to an aqueous solution changes hydrolytic property of lipase.
Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids.
Evaluation of the Tg.AC assay: specificity testing with three noncarcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components.
Inhibition of diphenolase activity of tyrosinase by vitamin b(6) compounds.
Inhibitory effects of (S)- and (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acids on tyrosinase activity.
Direct conversion of tert-beta-bromo alcohols to ketones with zinc sulfide and DMSO.
Permeabilization and in situ adsorption studies during growth and coumarin production in hairy root cultures of Cichorium intybus L.
Influence of some technological parameters on the formation of dimethyl sulfide, 2-mercaptoethanol, methionol, and dimethyl sulfone in port wines.
Redox signaling in the growth and development of colonial hydroids.
Evaluation of the No Observed Adverse Effect Level of Solvent Dimethyl Sulfoxide in Drosophila melanogaster.
Evidence for Escherichia coli O157:H7 attachment to water distribution pipe materials by scanning electron microscopy.
Toxicity of methylsulfonylmethane in rats.
Factors affecting the uptake of DMSO by the eggs and embryos of medaka, Oryzias latipes.
Examination of a vehicle for use with water soluble materials in the murine local lymph node assay.
Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytes.
Rheology of hyaluronan solutions under extensional flow.
Detection of genetically modified coho salmon using polymerase chain reaction (PCR) amplification.
Effect of dimethyl sulfoxide on the structure and the functional properties of horseradish peroxidase as observed by spectroscopy and cyclic voltammetry.
Simple cryoprotection and cell dissociation techniques for application of the comet assay to fresh and frozen rat tissues.
The influence of the solvents DMSO and ethanol on the genotoxicity of alpha,beta-unsaturated aldehydes in the SOS chromotest.
Plasma membrane aquaporins in the motor cells of Samanea saman: diurnal and circadian regulation.
Formation of methanethiol and dimethyl disulfide in crushed tissues of broccoli florets and their inhibition by freeze-thawing.
Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media.
Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin.
DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus.
Improvement of megakaryocytic progenitor culture for toxicological investigations.
Effect of dimethylsulfoxide on hydrolysis of lipase.
Modification of octamer binding transcriptional factor is related to H2B histone gene repression during dimethyl sulfoxide-dependent differentiation of HL-60 cells.
Origin of multiexponential T(2) relaxation in muscle myowater.
Rapid and specific detection of hydroxyl radical using an ultraweak chemiluminescence analyzer and a low-level chemiluminescence emitter: application to hydroxyl radical-scavenging ability of aqueous extracts of Food constituents.
Characterization of odorant compounds of mussels (Mytilus edulis) according to their origin using gas chromatography-olfactometry and gas chromatography-mass spectrometry.
Effect of Inula viscosa extract on chitin synthesis in dermatophytes and Candida albicans.
Characterization of a solvent resistant and thermostable aminopeptidase from the hyperthermophillic bacterium, Aquifex aeolicus.
Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (Procyanidins) from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds.
Antimutagenicity of the purple pigment, hordeumin, from uncooked barley bran-fermented broth.
Induction of unscheduled DNA synthesis in primary human urothelial cells by the mycotoxin ochratoxin A.
Antimicrobial Effects of Propolis Extracts on Escherichia coli and Staphylococcus aureus Strains Resistant to Various Antibiotics and Some Microorganisms.
Surface partitioning studies of N-methylcarbamate-treated post-harvest crops using SFE-HPLC-postcolumn reaction-fluorescence.
Cryopreservation of isolated fish blastomeres: effects of cell stage, cryoprotectant concentration, and cooling rate on postthawing survival
Isomerization of trans-astaxanthin to cis-isomers in organic solvents.
Free radical scavenging activity of grape seed extract and antioxidants by electron spin resonance spectrometry in an H(2)O(2)/NaOH/DMSO system.
Evaluation of free radical scavenging activities of antioxidants with an H(2)O(2)/NaOH/DMSO system by electron spin resonance.
Determination of solution conformations of PrP106-126, a neurotoxic fragment of prion protein, by 1H NMR and restrained molecular dynamics.
Teratogenicity of thujaplicin in ICR mice.
Biocompatibility of a biodegradable in situ forming implant system in rhesus monkeys.
Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats, utilization of stable isotopes and inductively-coupled plasma mass spectrometry technique.
Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers.
Adhesion of Aeromonas hydrophila to water distribution system pipes after different contact times.
Selective induction of type 2 cytokines following topical exposure of mice to platinum salts.
Effects of hydrolysis of milk glycerides on the antimutagenicity of a hexane extract of milk.
Comparison of the effects of the antimetastatic compound ImH[trans-RuCl4(DMSO)Im] (NAMI-A) on the arthritic rat and on MCa mammary carcinoma in mice.
Procedure for detecting and confirming pentobarbital residues in dog food by gas chromatography/mass spectrometry.
Antimutagenic properties of probiotic bacteria and of organic acids.
Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship?
Residue avoidance after topical application of veterinary drugs and parasiticides.
Furaltadone cytotoxicity on three cell lines in the presence or absence of DMSO: comparison with furazolidone.
Determination of PCB metabolites in Canadian human milk.
Selective suppression of in vitro T-dependent humoral immunity by synthetic food additive antioxidants.
Determination of reserpine and chlorothiazide in commercial tablets by liquid chromatography with fluorescence and UV absorbance detectors in series.
Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.
Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.
Antimutagenicity of an acetone extract of yogurt.
Mechanism of solvent-induced thermal stabilization of alpha-amylase from Bacillus amyloliquefaciens.
Structural stability of lipase from wheat germ.
Low levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide.
Enzymatic/chemical analysis of dietary fiber.
Immunoassay monitoring of polychlorinated biphenyls (PCBs) in the Great Lakes.
Native ordered structure of welan polysaccharide: conformational transitions and gel formation in aqueous dimethyl sulphoxide.
Contribution of phenolic and quinonoid structures in the mutagenicity of the edible mushroom Agaricus bisporus.
Transformation of BALB/c-3T3 cells: III. Development of a co-culture clonal survival assay for quantification of chemical cytotoxicity in high-density cell cultures.
Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures.
Oxygen radical formation during prostaglandin H synthase-mediated biotransformation of butylated hydroxyanisole.
Preparation and characterization of some alpha-D-glucans containing 3,6-anhydro D-glucose.
Regulation of G418 selection efficiency by cell-cell interaction in transfection.
Consequences of chemical modifications on the free radical reactions of human hemoglobin.
The covalent binding of acetaminophen to cellular nucleic acids as the result of the respiratory burst of neutrophils derived from the HL-60 cell line.
Percutaneous absorption of benzyl acetate through rat skin in vitro. 2. Effect of vehicle and occlusion.
Analysis of solvent control and 1-nitrosopyrene-induced Chinese hamster ovary cell mutants by Southern and northern blots and the polymerase chain reaction.
Iron-mediated oxidative DNA damage detected by fluorometric analysis of DNA unwinding in isolated rat liver nuclei.
Serum glucose and insulin responses to an insulin-containing ophthalmic solution administered topically in clinically normal cats.
Decreased incidence of diphenylamine-induced renal papillary necrosis in Syrian hamsters given dimethylsulphoxide.
Structure of oxidatively damaged nucleic acid adducts. 3. Tautomerism, ionization and protonation of 8-hydroxyadenosine studied by 15N NMR spectroscopy.
Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.
A comparison of the HL-60 cell line and human granulocytes to effect the bioactivation of arylamines and related xenobiotics. The binding of 2-aminofluorene to nucleic acids as the result of the respiratory burst.
Toxicity of dimethyl sulfoxide as a solvent in bioassay system with HeLa cells evaluated colorimetrically with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide.
15N nuclear magnetic resonance studies on the tautomerism of 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and other C8-substituted guanine nucleosides.
Tissue accumulation of lipoprotein associated toxaphene in normo- and hypolipidemic mice.
Effect of polymyxin B nonapeptide and polymyxin B sulphate on trichothecene mycotoxin sensitivity of yeasts using a conductimetric instrument.
Permeability of human granulocytes to dimethyl sulfoxide.
Recovery of soluble dietary fiber is dependent on the method of analysis.
Differential effects of dehydroepiandrosterone and clofibrate on the binding of 7,12-dimethyl benz(a)anthracene to hepatic DNA in vivo--a preliminary study.
Effects of a brain-enhanced chemical delivery system for estradiol on body weight and food intake in intact and ovariectomized rats.
Metallothionein response to stress in rats: role in free radical scavenging.
Cholesterol-induced atherosclerosis in the rabbit: effect of dimethyl sulfoxide on existing lesions.
Modulation of cyclic AMP and autoregulation of renal blood flow, analysed by the use of forskolin and 1-methyl-3-isobutylxanthine.
Chronic weight loss in lean and obese rats with a brain-enhanced chemical delivery system for estradiol.
Inhibition of cholesterol-induced atherosclerosis in rabbits by dimethyl sulfoxide.
The effect of dimethyl sulfoxide on cholesterol and bile acid metabolism in rats.
Some modification to the media for rapid automated detection of salmonellas by conductance measurement.
Comparison of penetration and metabolism of [3H]diacetoxyscirpenol, [3H]verrucarin A and [3H]T-2 toxin in skin.
Dimethyl sulfoxide (DMSO): a review.
Studies on germinal effects of quercetin, a naturally occurring flavonoid.
Beta-carotene as an inhibitor of benzo(a)pyrene and mitomycin C induced chromosomal breaks in the bone marrow of mice.
Dimethyl sulfoxide as a vehicle for food allergy patch tests.
DMSO, hobby shops and the FDA: the diffusion of a health policy dilemma.
Long lasting behavioral effects of dimethyl sulfoxide and the "peripheral" toxicant p-bromophenylacetylurea.
Liquid chromatographic determination of trace residues of polynuclear aromatic hydrocarbons in smoked foods.
Differentiation induction of murine erythroleukemia cells by butylated hydroxytoluene.
Brine shrimp (Artemia salina) nauplii as a teratogen test system.
Negative Ames tests of epoxide fatty methyl esters derived from hemolysis of linoleic acid hydroperoxides.
The status of dimethyl sulfoxide from the perspective of the Food and Drug Administration.
Survival of Campylobacter jejuni inoculated into ground beef.
Dimethyl sulfoxide. Controversy and current status--1981. Council on scientific affairs.
Hepatic effects of R-goitrin in Sprague-Dawley rats.
Dimethyl sulfoxide (DMSO)--an overview.
Natural occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains, and beverages.
A method for determining the maximum tolerated dose for in vivo cytogenetic analysis.
Use of DMSO for unapproved indications.
Playing politics at the FDA's expense.
Effect of sample transport systems on survival of bacteria in ground beef.
Teratology studies in mice exposed to municipal drinking-water concentrates during organogenesis.
The relationship between energy-dependent phagocytosis and the rate of oxygen consumption in Tetrahymena.
Effects of dimethyl sulfoxide on Tetrahymena pyriformis GL. Fine structural changes and their reversibility.
Citrinin mycotoxicosis in the mouse.
Provocative testing for food allergy diagnosis.
High-pressure liquid chromatographic analysis of urea herbicides in foods.
Evaluation and confirmation of an alkylation-gas-liquid chromatographic method for the determination of carbamate and urea herbicides in foods.
Instability of methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl) in various solvents.
Specific oxidation of methionine to methionine sulfoxide by dimethyl sulfoxide.
[Toxicity of food additives. -I. Injury of the membrance and inhibition of lipid peroxidation induced by BHA on the liver mitochondria and lysosomes of the rat. Role of the solvents used for solubilization of the compound].
Correlation between the carcinogenicities of nitrofuran derivatives and their destructive actions on sebaceous glands of mouse skin.
Summary of the dimethyl sulfoxide conference.
Opening remarks.
Discussion paper: dimethyl sulfoxide as a cryoprotective agent for platelet preservation by freezing.
Drugs and trends; the "unproven" "proven" drug.
Oxidation of amino acids by dimethyl sulfoxide.
Function of lipophilic acids as antimicrobial food additives.
Food supply as a factor in the survival of frozen thawed and rotifers.
Dimethylsulphoxide: a fallen idol.
Government responsibilities in the development of new drugs.
The development of drugs and the responsibilities involved.
Effects of DMSO on blood and vascular endothelium.
The future of therapy.
A comparison of fibrous-residue determinations by the official (A.O.A.C.) method and the dimethylsulphoxide method.
Dimethylsulphoxide: its uses and toxicology.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
FDA Indirect Additives used in Food Contact Substances:	View
CHEBI:	View
CHEMBL:	View
UM BBD:	Search
KEGG (GenomeNet):	C11143
HMDB (The Human Metabolome Database):	HMDB02151
FooDB:	FDB000764
Export Tariff Code:	2930.90.9190
MedlinePlusSupp:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
FAO:	Methylsulfinylmethane
Formulations/Preparations: •dimethyl sulfoxide is presently available as rimso-5, in a 50% aqueous solution. •u.s. - 50% [rimso-50; generic]; canada - 50% [rimso-50].

Suppliers

Arkema	Aromiens International
Augustus Oils	BOC Sciences
Charkit Chemical	Connect Chemicals
Covalent Chemical	ECSA Chemicals
EMD Millipore	Glentham Life Sciences
Indis NV	Penta International
Santa Cruz Biotechnology	Shiva Chemicals and Pharmaceuticals
Sigma-Aldrich	Synerzine
SysKem Chemie	TCI AMERICA
Tengzhou Jitian Aroma Chemiclal	Augustus Oils Ltd
Charkit Chemical Corporation	Glentham Life Sciences Ltd
Penta International Corporation	Synerzine, Inc.

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	78.134017944336
Specific gravity	@ 25 °C
Pounds per Gallon	9.045 to 9.087
Refractive Index	1.469 to 1.48 @ 20 °C
Melting Point	17 to 19°C @ 760 mm Hg
Boiling Point	189 to 190°C @ 760 mm Hg
Vapor Pressure	0.61 mmHg @ 25 °C
Vapor Density	2.7
Flash Point TCC Value	83.89 °C TCC
logP (o/w)	-1.35
Solubility
alcohol	Yes
oil	Yes
water, 1e+006 mg/L @ 25 °C (est)	Yes

Organoleptic Properties

Odor Type: Alliaceous
fatty, oily, cheesy, garlic, mushroom, salty
General comment	At 0.10 % in dipropylene glycol. fatty oily cheesy garlic mushroom
Mosciano, Gerard P&F 24, No. 6, 10, (1999)	At 100.00 %. Fatty, oily, cheesy, over-cooked stir-fry, salty and garlic, mushroom, garlic with a cracker and soy nuance
Flavor Type: Fatty
fatty, salty, garlic, creamy, corn
Mosciano, Gerard P&F 24, No. 6, 10, (1999)	At 40.00 ppm. Fatty, salty, garlic and cream corn

Occurrences

Potential Uses

Applications	multipurpose additives
Flavoring purposes	Cheese, Corn, Dairy, Garlic, Mushroom
Cosmetic purposes	Not used anymore

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 23 - Do not breath vapour. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M,F] 20000 mg/kg (Brown et al., 1963) gavage-mouse LD50 [sex: M,F] 20000 mg/kg (Brown et al., 1963) oral-mouse LD50 [sex: M,F] 21400 mg/kg (Willson et al., 1965) oral-rat LD50 [sex: M,F] 28300 mg/kg (Willson et al., 1965) oral-mouse LD50 [sex: M,F] 16500 mg/kg (Sommer & Tauberger, 1964) oral-rat LD50 [sex: M,F] 19700 mg/kg (Sommer & Tauberger, 1964) oral-mouse LD50 3100 mg/kg (Fishman et al., 1969) oral-rat LD50 14500 mg/kg (Fishman et al., 1969) oral-bird - wild LD50 100 mg/kg Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. intravenous-cat LDLo 200 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1571, 1978. oral-chicken LD50 12000 mg/kg Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963. intravenous-dog LD50 2500 mg/kg CARDIAC: OTHER CHANGES KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES Cancer Chemotherapy Reports. Vol. 31, Pg. 7, 1963. oral-dog LD50 > 10000 mg/kg Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967. intraperitoneal-guinea pig LDLo > 5500 mg/kg Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963. oral-guinea pig LDLo > 11000 mg/kg Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963. oral-mammal (species unspecified) LD50 21400 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974. intravenous-man TDLo 606 mg/kg LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 2, Pg. 1004, 1980. intraperitoneal-mouse LD50 2500 mg/kg Russian Pharmacology and Toxicology Vol. 35, Pg. 300, 1972. intravenous-mouse LD50 3100 mg/kg SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969. oral-mouse LD50 7920 mg/kg Chimica Therapeutica. Vol. 3, Pg. 10, 1968. unreported-mouse LD50 12000 mg/kg United States Patent Document. Vol. #4767763 intraperitoneal-rat LD50 8200 mg/kg Food and Chemical Toxicology. Vol. 22, Pg. 665, 1984. intravenous-rat LD50 5360 mg/kg BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: DYSPNEA Toxicology and Applied Pharmacology. Vol. 7, Pg. 104, 1965. oral-rat LD50 14500 mg/kg SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969. unreported-rat LD50 1300 mg/kg National Technical Information Service. Vol. AD-A159-418
Dermal Toxicity:
skin-rat LD50 40000 mg/kg National Technical Information Service. Vol. AD-A159-418 subcutaneous-rat LD50 12000 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1050, 1964. subcutaneous-mouse LD50 14000 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: HEMATURIA Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967. skin-mouse LD50 50000 mg/kg Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967. skin-rat LD50 40000 gm/kg Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
multipurpose additives
Recommendation for dimethyl sulfoxide usage levels up to:
	not for fragrance use.

Maximised Survey-derived Daily Intakes (MSDI-EU):		ND (μg/capita/day)
Structure Class:		III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 18
Click here to view publication 18
		average usual ppm	average maximum ppm
baked goods:		0.10000	5.00000
beverages(nonalcoholic):		0.10000	5.00000
beverages(alcoholic):		-	-
breakfast cereal:		0.10000	5.00000
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		0.10000	5.00000
fruit ices:		-	-
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		0.10000	5.00000
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		0.10000	5.00000
milk products:		0.10000	5.00000
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		100.00000	1000.00000
snack foods:		-	-
soft candy:		0.10000	5.00000
soups:		0.10000	5.00000
sugar substitutes:		-	-
sweet sauces:		0.10000	5.00000

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20
View page or View pdf

Flavouring Group Evaluation 74 (FGE.74)[1]: Consideration of Simple Aliphatic Sulphides and Thiols evaluated by JECFA (61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08 (2008)
View page or View pdf

Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf

Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf

Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
View page or View pdf

EPI System: View

ClinicalTrials.gov:search

Daily Med:search

NIOSH International Chemical Safety Cards:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):67-68-5

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry