(Z)-12-musk decenone

(Z)-12-musk decenone, also known by synonyms such as (12Z)-oxacyclohexadec-12-en-2-one and (Z)-habanolide, is a macrocyclic musk chemical with the molecular formula C₁₅H₂₆O₂. This compound appears as a clear substance notable for its characteristic musk odor. Classified within organic lactones, it is widely employed in the fragrance industry due to its musk-like scent profile that enhances various perfume compositions. Its chemical structure includes a 16-membered ring lactone with a Z-configured double bond, which influences its volatility and odor potency. The compound is sourced through synthetic organic chemistry routes rather than from natural sources. Detailed information about its chemical identity is available in standard databases such as PubChem.

(Z)-12-musk decenone occurs as a synthetic musk used primarily in fragrance formulations to impart warm, animalic, and musky notes. It is widely recognized within fragrance and flavor regulatory frameworks, including the IFRA (Global) standards, which govern use limits for safety and product quality. Its musk scent lends complexity to perfumes with accords ranging from floral and woody to oriental and powdery themes. In addition to perfumery, the compound finds minor application in flavoring, although its use as a flavor additive is generally not recommended or authorized. Its versatility extends to use as a replacement for natural musk-like ingredients in various aroma blends, enhancing the sensory appeal and diffusion characteristics of consumer products.

(Z)-12-musk decenone is characterized by a relatively high boiling point near 383 to 384°C at standard atmospheric pressure, marking it as a thermally stable compound suitable for heated processes during formulation. It has an estimated logP of approximately 4.95, indicating considerable lipophilicity, which correlates with limited water solubility—measured near 1.859 mg/L at 25°C—and good solubility in alcohols. These features influence its behavior in formulations, favoring oil-based or solvent-containing systems where it can be effectively dispersed. The estimated flash point of 161°C (322°F) suggests moderate flammability risk under controlled use conditions. These physicochemical traits are pivotal when determining compatibility and stability in complex fragrance matrices.

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Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for (Z)-12-musk decenone flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

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Toxicology Citations:Search

EPA Substance Registry Services (TSCA):111879-79-9

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

(12Z)-1-oxacyclohexadec-12-en-2-one

Chemidplus:0111879799