| Preferred name | advantame |
| Trivial Name | (3R)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-[3-(3-hydroxy-4-methoxy-phenyl)propylamino]-4-oxo-butanoic acid hydrate |
| Short Description | N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl-alpha-L-phenylalanine methyl ester, monohydrate |
| Formula | C24 H32 N2 O8 |
| CAS Number | 714229-20-6 |
| FEMA Number | 4716 |
| FDA UNII | 3ZA6810AWX |
| NMR Predictor | External link |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 714229-20-6 ; ADVANTAME |
| Synonyms |
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| Google Scholar | Start search |
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| Perfumer & Flavorists | Start search |
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| (3R)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-[3-(3-hydroxy-4-methoxy-phenyl)propylamino]-4-oxo-butanoic acid hydrate | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 56843846 |
| Pubchem (sid): | 135268538 |
| Publications by Google Patents | |
| Sweetener compositions and uses thereof | |
| Publications by US Patents | |
| 8,945,652 - High-potency sweetener for weight management and compositions sweetened therewith | |
| Publications by EU Patents | |
| ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS | |
| NOVEL ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS | |
| Publications by Leffingwell & Associates | |
| Flavor Properties of FEMA GRAS List 25 flavor chemicals | |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | Search |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Material listed in food chemical codex | No |
| Molecular weight | 476.5266418457 |
| Flash Point TCC Value | N/a |
| Solubility | |
| alcohol | Yes |
| water, 12.48 mg/L @ 25 °C (est) | Yes |
| water | No |
| Flavor Type: Sweet | |
| sweet, sugar |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| sweeteners, flavor enhancers | |||
| Recommendation for advantame usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 25. Update in publication number(s): 29 | |||
| Click here to view publication 25 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 20.00000 | 20.00000 | |
| beverages(nonalcoholic): | 1.35000 | 1.50000 | |
| beverages(alcoholic): | 3.00000 | 3.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 40.00000 | 50.00000 | |
| condiments / relishes: | 3.00000 | 3.00000 | |
| confectionery froastings: | 3.75000 | 3.75000 | |
| egg products: | - | - | |
| fats / oils: | 3.00000 | 3.00000 | |
| fish products: | - | - | |
| frozen dairy: | 0.90000 | 1.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | 3.75000 | 3.75000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | 0.75000 | 0.75000 | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | 0.90000 | 1.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | 3.75000 | 3.75000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Authority (EFSA) reference(s): |
| Scientific Opinion on the safety of advantame for the proposed uses as a food additive View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :56843846 |
| National Institute of Allergy and Infectious Diseases:Data |
| (3R)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-[3-(3-hydroxy-4-methoxy-phenyl)propylamino]-4-oxo-butanoic acid hydrate |
| Chemidplus:0714229206 |