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General Material Information

Preferred name (1R,2S)-(-)-ephedrine hydrochloride
Trivial Name (-)-Ephedrine hydrochloride
Short Description (1R,2S)-2-(methylamino)-1-phenyl-1-propanol hydrochloride (1:1)
Formula C10 H16 Cl N O
CAS Number 50-98-6
Deleted CAS Number 14992-57-5
ECHA Number 200-074-6
FDA UNII NLJ6390P1Z
Beilstein Number 3630391
MDL MFCD00066127
Bio Activity Summary External link
NMR Predictor External link
Synonyms
  • (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol; hydrochloride
  • (-)-ephedrine hydrochloride
  • (1R,2S)-ephedrine hydrochloride
  • (1R,2S)-(-)-2-methylamino-1-phenyl-1-propanol hydrochloride
  • (1R,2S)-2-(methylamino)-1-phenyl-1-propanol hydrochloride (1:1)
  • (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol hydrochloride (1:1)
  • (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride
  • (1R,2S)-a-[1-( methylamino)ethyl]benzyl alcohol hydrochloride
  • [R-(R*,S*)]-a-[1-(methylamino)ethyl]benzenemethanol hydrochloride
  • altusin
  • benzenemethanol, a-[(1S)-1-(methylamino)ethyl]-, (aR)-, hydrochloride (1:1)
  • bronkotabs
  • ephedroguent
  • ephedronguent
  • L- erythro-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride
  • L-erythro-ephedrine hydrochloride
  • primatene tablets
  • quadrinal
  • sanedrine
  • tedral
  • Benzenemethanol, α-[(1S)-1-(methylamino)ethyl]-, hydrochloride (1:1), (αR)-
  • Ephedrine, hydrochloride, (-)-
  • Benzenemethanol, α-[1-(methylamino)ethyl]-, hydrochloride, [R-(R*,S*)]-
  • Benzenemethanol, α-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (αR)-
  • Ephedrine hydrochloride
  • l-Ephedrine hydrochloride
  • l-α-[1-(Methylamino)ethyl]benzyl alcohol hydrochloride
  • Ephedrinium chloride
  • (-)-Ephedrin hydrochloride
  • CPDD 0047
  • Ephedral
  • (1R,2S)-(-)-2-Ephedrinium hydrochloride
  • Enurace

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D01386
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.40.5000
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 201.6957244873
Vapor Pressure 0.00865 mmHg @ 25 °C
Flash Point TCC Value 85.6 °C TCC
logP (o/w) 1.054 est
Solubility
water, 2.50E+05 mg/L @ 25 °C (exp) Yes
water, 1e+006 mg/L @ 25 °C (est) Yes

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 60 mg/kg
CARDIAC: OTHER CHANGES
Medecine Vol. 9, Pg. 59, 1930.

intravenous-dog LDLo 70 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Medecine Vol. 9, Pg. 59, 1930.

parenteral-frog LDLo 440 mg/kg
Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925.

intravenous-guinea pig LD50 98 mg/kg
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.

intraperitoneal-hamster LDLo 350 mg/kg
CARDIAC: OTHER CHANGES
Medecine Vol. 9, Pg. 59, 1930.

intraperitoneal-mouse LD50 242 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 135, 1967.

intravenous-mouse LD50 95 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.

oral-mouse LD50 400 mg/kg
Journal of Medicinal Chemistry. Vol. 9, Pg. 966, 1966.

parenteral-mouse LDLo 500 mg/kg
Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925.

intramuscular-rabbit LD50 175 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

intravenous-rabbit LD50 65 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.

intraperitoneal-rat LD50 165 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

intravenous-rat LD50 69 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 33, Pg. 80, 1944.

Dermal Toxicity:
subcutaneous-dog LDLo 220 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Medecine Vol. 9, Pg. 59, 1930.

subcutaneous-frog LDLo 400 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Medecine Vol. 9, Pg. 59, 1930.

subcutaneous-guinea pig LD50 192 mg/kg
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.

subcutaneous-mouse LD50 40870 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946.

subcutaneous-rabbit LD50 165 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.

subcutaneous-rat LD50 1150 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
pharmaceuticals / chemical synthisis
Recommendation for (1R,2S)-(-)-ephedrine hydrochloride usage levels up to:
not for fragrance use.
Recommendation for (1R,2S)-(-)-ephedrine hydrochloride flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):50-98-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :65326
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride
Chemidplus:0000050986
RTECS:KB1750000 for cas# 50-98-6