(S)-(+)-2-octanol

(S)-(+)-2-Octanol is a chiral secondary alcohol with the molecular formula C₈H₁₈O. It appears as a liquid and is characterized by a distinct mushroom-like odor described as oily, fatty, creamy, with subtle grape nuances. The compound is known by multiple synonyms including (2S)-octan-2-ol, S-(+)-2-octanol, and D-(+)-octan-2-ol. It is catalogued under the controlled vocabulary identifier CHEBI:37870. Derived primarily through stereoselective chemical synthesis, (S)-(+)-2-octanol is predominantly utilized for informational and research purposes. Commercial use in fragrances or flavorings is not established, partially due to its sensory profile and regulatory status. Detailed chemical and safety data are accessible through reputable chemical databases, supporting academic and industrial research needs.

(S)-(+)-2-Octanol does not occur widely in nature but may be found in trace amounts within certain biological systems due to its octanol backbone. Its main application is informational; it is not used in fragrance or flavor formulations. This compound is assessed under REACH (EU) regulations and other chemical safety standards but lacks authorization for consumer product flavors or perfumes. The mushroom-like odor suggests potential sensory interest; however, its practical use remains confined to academic studies and reference in stereochemical research. The absence of commercial utilization reflects both regulatory decisions and the compound's niche chemical characteristics.

(S)-(+)-2-Octanol exhibits moderate hydrophobicity with an estimated logP of approximately 2.7, indicating balanced solubility between aqueous and organic phases. Its specific gravity ranges narrowly from 0.82 to 0.823 at 20 °C, denoting a slightly lighter-than-water liquid. Refractive index measurements between 1.424 and 1.427 at 20 °C support optical characterization. Vapor pressure is low, approximately 0.306 mmHg at 25 °C, which correlates with its relatively high boiling point. It is soluble in alcohols and shows limited but measurable solubility in water around 990 to 1280 mg/L at 25 °C. The compound’s flash point is estimated near 71 °C, reflecting moderate flammability. These properties affect handling, storage, and potential incorporation into chemical formulations, despite its restricted use.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
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(IUPAC):	Periodic Table of the Elements
CHEBI:	View
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2905.16.0010
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Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
information only not used for fragrances or flavors
Recommendation for (S)-(+)-2-octanol usage levels up to:
	not for fragrance use.
Recommendation for (S)-(+)-2-octanol flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):6169-06-8

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :2723888

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

(2S)-octan-2-ol

Chemidplus:0006169068