2-thienyl methanol

General Material Information

Preferred name	2-thienyl methanol
Trivial Name	2-Thiophenemethanol
Short Description	thiophen-2-ylmethanol
Formula	C5 H6 O S
CAS Number	636-72-6
FEMA Number	4642
ECHA Number	211-264-3
FDA UNII	279633QQ3D
Nikkaji Number	J82E
Beilstein Number	0383595
MDL	MFCD00005454
xLogP3-AA	0.90 (est)
Bio Activity Summary	External link
NMR Predictor	External link
JECFA Food Flavoring	2111 2-thienylmethanol
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	636-72-6 ; 2-THIENYLMETHANOL
Synonyms	2-( hydroxymethyl) thiophene 2-( hydroxymethyl)thiophene 2-hydroxymethylthiophene thenyl alcohol 2-thenyl alcohol ( thien-2-yl)methanol 2-thienyl carbinol 2-thienylmethan-1-ol 2-thienylmethanol thiophen-2-yl-methanol ( thiophen-2-yl)methanol thiophen-2-ylmethanol 2-thiophene methanol thiophene-2-methanol 2-thiophenemethanol 2-Thiophenemethanol 2-(Hydroxymethyl)thiophene 2-Thenyl alcohol 2-Thienylmethanol 2-Thienylmethyl alcohol 2-Thienylcarbinol (Thiophen-2-yl)methanol NSC 89695

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

	thiophen-2-ylmethanol
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	69467
Pubchem (sid):	135026334
Pherobase:	View

Publications by Perfumer & Flavorist
Organoleptic Characteristics of Flavor Materials
Publications by PubMed
Simple preparation of Pd-NP/polythiophene nanospheres for heterogeneous catalysis.
Synthesis, structure elucidation and identification of antiproliferative activities of a novel class of thiophene bioisosteres bearing the privileged 7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one scaffold.
The effect of methanol treatment on the performance of polymer solar cells.
Synthesis, photophysical properties and solvatochromism of meso-substituted tetramethyl BODIPY dyes.
Effects of hydrogen bond and solvent polarity on the C=O stretching of bis(2-thienyl)ketone in solution.
Gold nanoparticles incarcerated in nanoporous syndiotactic polystyrene matrices as new and efficient catalysts for alcohol oxidations.
Facile preparation of SERS-active nanogap-rich Au nanoleaves.
Interactions of diorganolead(IV) with 3-(2-thienyl)-2-sulfanylpropenoic acid and/or thiamine: chemical and in vitro and in vivo toxicological results.
A two-dimensional network formed by self-associating silver(I) perchlorate with 3-[4-(2-thienyl)-2H-cyclopenta[d]pyridazin-1-yl]benzonitrile.
Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive response.
Enantioselective HPLC of potentially CNS-active acidic amino acids with a Cinchona carbamate based chiral stationary phase.
Copper(I)-Fesulphos Lewis Acid catalysts for enantioselective Mannich-type reaction of N-sulfonyl imines.
Syntheses and ligand interconversions of copper(II) derivatives of the metalloligand [Pt2(mu-S)2(PPh3)4].
Kinin-induced anion-dependent secretion in porcine ileum: characterization and involvement of opioid- and cannabinoid-sensitive enteric neural circuits.
Copper(II) complexes of novel N-alkylated derivatives of cis,cis-1,3,5-triaminocyclohexane. 1. Preparation and structure.
Proton magnetic resonance studies of bradykinin antagonists.
Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	HMDB32993
FooDB:	FDB010982
YMDB (Yeast Metabolome Database):	YMDB01447
Export Tariff Code:	2934.90.5000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Suppliers

Axsyn	BOC Sciences
Parchem	Penta International
Santa Cruz Biotechnology	Sigma-Aldrich: Aldrich
TCI AMERICA	Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	114.16702270508
Specific gravity	@ 20 °C
Pounds per Gallon	10.038 to 10.122
Refractive Index	1.562 to 1.568 @ 20 °C
Boiling Point	206 to 207°C @ 760 mm Hg
Vapor Pressure	0.139 mmHg @ 25 °C
Flash Point TCC Value	110 °C TCC
logP (o/w)	0.87
Storage notes	Store under nitrogen.
Solubility
alcohol	Yes
water, 6.158e+004 mg/L @ 25 °C (est)	Yes

Organoleptic Properties

Odor Type: Savory
savory, coffee roasted coffee, coffee
General comment	At 0.10 % in propylene glycol. savory roasted coffee

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for 2-thienyl methanol usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
		average usual ppm	average maximum ppm
baked goods:		-	-
beverages(nonalcoholic):		-	-
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		0.00100	0.01000
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		0.00500	0.10000
soft candy:		-	-
soups:		0.00100	0.01000
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :69467

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

thiophen-2-ylmethanol

Chemidplus:0000636726