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4-hydroxymethyl-pyridine

Chemical Structure

General Material Information

Preferred name 4-hydroxymethyl-pyridine
Trivial Name 4-Pyridinemethanol
Short Description 4-pyridylcarbinol
Formula C6 H7 N O
CAS Number 586-95-8
ECHA Number 209-590-6
FDA UNII Search
Nikkaji Number J85.689D
Beilstein Number 107850
MDL MFCD00006442
Bio Activity Summary External link
NMR Predictor External link
Synonyms
  • 4-hydroxymethyl pyridine
  • 4-( hydroxymethyl)pyridine
  • 4-hydroxymethylpyridine
  • 4-picolyl alcohol
  • gamma- picolyl alcohol
  • 4-pyridin-4-ylmethanol
  • 4-pyridinecarbinol
  • 4-pyridinemethanol
  • 4-pyridyl carbinol
  • 4-pyridylcarbinol
  • 4-pyridylmethanol
  • pyridin-4-ylmethanol
  • 4-Pyridinemethanol
  • 4-(Hydroxymethyl)pyridine
  • 4-Pyridylcarbinol
  • 4-Pyridylmethanol
  • γ-Picolyl alcohol
  • 4-Pyridinecarbinol
  • 4-Picolyl alcohol
  • 4-Pyridylmethyl alcohol
  • (Pyridin-4-yl)methanol
  • NSC 126907
  • NSC 26024
  • NSC 49167
  • 4-(Hydroxymethylene)pyridine

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

pyridin-4-ylmethanol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):11472
Pubchem (sid):134975976
Publications by US Patents
3,952,024 - Furfurylthioacetone
Certain 2,5-dimethyl-3-thiopyrazines
Publications by PubMed
The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine.
Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI).
Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines.
Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria.
Chelation-assisted transformation: synthesis of 1,4-dicarboxylate esters by the Rh-catalyzed carbonylation of internal alkynes with pyridin-2-ylmethanol.
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.
Recognition of DNA modified by trans-[PtClNH(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex.
Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine.
The thermal and light induced spin transition in [FeL2](BF4)2 (L = 2,6-dipyrazol-1-yl-4-hydroxymethylpyridine).
On the formation of isopropylidenepyridoxines. A convenient method for the preparation of 2,2,8-trimethyl-4H-1,3-dioxino[4,5-c]pyridin-5-ylmethanol from pyridoxine hydrochloride.
[Pharmacodynamic study of (M-14012-4) N-(4-picolyl)-3,5-dimethylbenzamide].

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.39.9100
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 109.12799072266
Vapor Pressure 0.026 mmHg @ 20 °C
Flash Point TCC Value 110 °C TCC
logP (o/w) 0.06
Solubility
water, 1.00E+06 mg/L @ 20 °C (exp) Yes

Organoleptic Properties

Flavor Type: Hazelnut
hazelnut, coffee, nutty
General comment Hazelnut- coffee-like

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 422 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

intravenous-mouse LD50 1000 mg/kg
Pharmazie. Vol. 11, Pg. 242, 1956.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
information only not used for fragrances or flavors
Recommendation for 4-hydroxymethyl-pyridine usage levels up to:
not for fragrance use.
Recommendation for 4-hydroxymethyl-pyridine flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):586-95-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11472
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
pyridin-4-ylmethanol
Chemidplus:0000586958
RTECS:UT4691000 for cas# 586-95-8