tetrachloromethane

General Material Information

Trival Name	tetrachloromethane
Short Description	tetrachloridocarbon
Formula	C Cl4
CAS Number	56-23-5
ECHA Number	200-262-8
FDA UNII	CL2T97X0V0
Nikkaji Number	J2.317E
Beilstein Number	1098295
MDL	MFCD00000785
xLogP3-AA	2.80 (est)
Bio Activity Summary	External link
NMR Predictor	External link
Applications	indirect food additives: adhesives and components of coatings
Synonyms	carbon tetrachloride [UN1846] [Poison] per chloromethane methane tetrachloride methane, tetrachloro- methanetetrachloride refrigerant R10 tetrachloride, carbon tetrachloridocarbon tetrachlorocarbon tetrachloromethane tetrafinol tetraform

Potential Uses

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Literature & References

	tetrachloromethane
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	56-23-5
Pubchem (cid):	5943
Pubchem (sid):	134972600

Publications by PubMed
Antioxidant and protective effect of inulin and catechin grafted inulin against CCl4-induced liver injury.
Differential protective effects of extra virgin olive oil and corn oil in liver injury: A proteomic study.
Antioxidant activities of tamarind (Tamarindus Indica) seed coat extracts using in vitro and in vivo models.
Investigation of antioxidant and hepatoprotective activity of standardized Curcuma xanthorrhiza rhizome in carbon tetrachloride-induced hepatic damaged rats.
Characterization of polysaccharides with antioxidant and hepatoprotective activities from the wild edible mushroom Russula vinosa Lindblad.
Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential.
Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway.
The effects of daily supplementation of Dendrobium huoshanense polysaccharide on ethanol-induced subacute liver injury in mice by proteomic analysis.
Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats.
Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats.
Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats.
Chemical composition, antioxidant activity and hepatoprotective potential of Rourea induta Planch. (Connaraceae) against CCl4-induced liver injury in female rats.
Characteristic vibrational frequencies of toxic polychlorinated dibenzo-dioxins and -furans.
Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats.
Sensitive quantitation of polyamines in plant foods by ultrasound-assisted benzoylation and dispersive liquid-liquid microextraction with the aid of experimental designs.
Antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hēi dòu) and astragalus membranaceus ( shēng huáng qí).
Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation.
Hepatoprotective activity of the neem-based constituent azadirachtin-A in carbon tetrachloride intoxicated Wistar rats.
Protective effect of Actiniopteris radiata (Sw.) Link. against CCl₄ induced oxidative stress in albino rats.
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Ligandless dispersive liquid--liquid microextraction of iron in biological and foodstuff samples and its determination by Electrothermal atomic absorption spectrometry.
Antioxidant and hepatoprotective effects of naringenin and its β-cyclodextrin formulation in mice intoxicated with carbon tetrachloride: a comparative study.
Hepatoprotective effects of Rubus coreanus miquel concentrates on liver injuries induced by carbon tetrachloride in rats.
Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury.
Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents.
Hepatoprotective effect of polyphenols rich methanolic extract of Amorphophallus commutatus var. wayanadensis against CCl4 induced hepatic injury in swiss albino mice.
Bovine lactoferrin ingestion protects against inflammation via IL-11 induction in the small intestine of mice with hepatitis.
Effects of boiling on chlorogenic acid and the liver protective effects of its main products against CCl₄-induced toxicity in vitro.
Oral hepatoprotective ability evaluation of purple sweet potato anthocyanins on acute and chronic chemical liver injuries.
Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats.
Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion.
Characterization, antioxidant and hepatoprotective activities of polysaccharides from Ilex latifolia Thunb.
Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway.
Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary.
Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine.
The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats.
Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics.
Hepatoprotective role of Nicotiana plumbaginifolia Linn. against carbon tetrachloride-induced injuries.
Structural characterization and antioxidant activity of a low-molecular polysaccharide from Dendrobium huoshanense.
An update on oxidative stress-mediated organ pathophysiology.
Hepatoprotective function of Penthorum chinense Pursh.
Dispersive liquid-liquid microextraction for the determination of vitamins D and K in foods by liquid chromatography with diode-array and atmospheric pressure chemical ionization-mass spectrometry detection.
Protective effects of Ziyang tea polysaccharides on CCl4-induced oxidative liver damage in mice.
Spectroscopic and biological approach in the characterization of a novel 14-membered [N4] macrocyclic ligand and its palladium(II), platinum(II), ruthenium(III) and iridium(III) complexes.
Appraisal of in vitro and in vivo antioxidant activity potential of cornelian cherry leaves.
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Characterisation of polysaccharides from green tea of Huangshan Maofeng with antioxidant and hepatoprotective effects.
Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury.
Hepatoprotective properties of the Indian gooseberry (Emblica officinalis Gaertn): a review.
Bamboo salt attenuates CCl4-induced hepatic damage in Sprague-Dawley rats.
Isolation, characterization, and hepatoprotective effects of the raffinose family oligosaccharides from Rehmannia glutinosa Libosch.
Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.
Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4.
Effects of yam peel extract against carbon tetrachloride-induced hepatotoxicity in rats.
CCl4 induces tissue-type plasminogen activator in rat brain; protective effects of oregano, rosemary or vitamin E.
Inhibitory effect of Nymphaea pubescens Willd. flower extract on carrageenan-induced inflammation and CCl₄-induced hepatotoxicity in rats.
Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial.
Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression.
Protective effects of Keemun black tea polysaccharides on acute carbon tetrachloride-caused oxidative hepatotoxicity in mice.
Response to: "Hormetic effect of Rosa laevigata Michx in CCl₄-induced hepatotoxicity and the presumptive role of PPARs".
Protective effects of kaempferol on isoniazid- and rifampicin-induced hepatotoxicity.
Hormetic effect of Rosa laevigata Michx in CCl₄-induced hepatotoxicity and the presumptive role of PPARs.
Combination of saponification and dispersive liquid-liquid microextraction for the determination of tocopherols and tocotrienols in cereals by reversed-phase high-performance liquid chromatography.
Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury.
Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway.
Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent.
Compositional characterisation of soluble apple polysaccharides, and their antioxidant and hepatoprotective effects on acute CCl4-caused liver damage in mice.
Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.
Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Liver injury induced by thirty- and fifty-nanometer-diameter silica nanoparticles.
Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats.
[Study of purity tests for silicone resins].
Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice.
The in vivo antioxidant and antifibrotic properties of green tea (Camellia sinensis, Theaceae).
DNA microarray analysis identified molecular pathways mediating the effects of supplementation of branched-chain amino acids on CCl4-induced cirrhosis in rats.
Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L.
Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats.
Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function.
Potential antioxidant properties and hepatoprotective effects of an aqueous extract formula derived from three Chinese medicinal herbs against CCl(4)-induced liver injury in rats.
Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice.
Combination of QuEChERS and DLLME for GC-MS determination of pesticide residues in orange samples.
Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride.
Antioxidant activity and potential hepatoprotective effect of polysaccharides from Cyclina sinensis.
CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat.
Monitoring pesticide residues in greenhouse tomato by combining acetonitrile-based extraction with dispersive liquid-liquid microextraction followed by gas-chromatography-mass spectrometry.
Antioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in rats.
Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride.
Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease.
Methyl helicterate protects against CCl4-induced liver injury in rats by inhibiting oxidative stress, NF-κB activation, Fas/FasL pathway and cytochrome P4502E1 level.
Xanthohumol prevents carbon tetrachloride-induced acute liver injury in rats.
Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats.
Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl(4)-Induced Acute Liver Injury.
Edible oils for liver protection: hepatoprotective potentiality of Moringa oleifera seed oil against chemical-induced hepatitis in rats.
Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat.
Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice.
The role of Kupffer cells in carbon tetrachloride intoxication in mice.
Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression.
A validated GC-MS method for the determination and quantification of residual solvents in counterfeit tablets and capsules.
Medium optimization and potential hepatoprotective effect of mycelial polysaccharides from Pholiota dinghuensis Bi against carbon tetrachloride-induced acute liver injury in mice.
Chemical composition and hepatoprotective effects of polyphenol-rich extract from Houttuynia cordata tea.
Serum and liver tissue bio-element levels, and antioxidant enzyme activities in carbon tetrachloride-induced hepatotoxicity: protective effects of royal jelly.
Resveratrol nanoparticle system improves dissolution properties and enhances the hepatoprotective effect of resveratrol through antioxidant and anti-inflammatory pathways.
Protective effect of Öküzgözü (Vitis vinifera L. cv.) grape juice against carbon tetrachloride induced oxidative stress in rats.
Ameliorative effect of Grewia tenax (Forssk) fiori fruit extract on CCl(4)-induced oxidative stress and hepatotoxicity in rats.
Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats.
Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis.
Protective effects of lotus (Nelumbo nucifera Gaertn) germ oil against carbon tetrachloride-induced injury in mice and cultured PC-12 cells.
Antifibrotic activity a fermentation filtrate of Ganoderma lucidum.
Hepatoprotective effects of total saponins isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats.
Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation.
Hepatoprotection of Gentiana scabra extract and polyphenols in liver of carbon tetrachloride-intoxicated mice.
Erythrocyte oxidative damage in rat treated with CCl4: protective role of vanillin.
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
Hepatoprotection of emodin and Polygonum multiflorum against CCl(4)-induced liver injury.
Hepatoprotective effects of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone on CCl4-induced acute liver injury in mice.
Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: an in vivo study.
Protective effect of red-stemmed type of Ipomoea aquatica Forsk against CCl4-induced oxidative damage in mice.
Preparation, preliminary characterization, antioxidant, hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant (Camellia sinensis).
Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl₄ induced hepatic oxidative damage and renal failure in rats.
Multipesticide residue analysis in maize combining acetonitrile-based extraction with dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry.
Low-molecular-weight lignin-rich fraction in the extract of cultured Lentinula edodes mycelia attenuates carbon tetrachloride-induced toxicity in primary cultures of rat hepatocytes.
Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats.
Antioxidant, hepatoprotective, and ameliorative effects of methanolic extract of leaves of Grewia mollis Juss. on carbon tetrachloride-treated albino rats.
Antioxidant and antihepatotoxic effect of Spirulina laxissima against carbon tetrachloride induced hepatotoxicity in rats.
Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats.
Chlorella vulgaris extract ameliorates carbon tetrachloride-induced acute hepatic injury in mice.
Protective effect of Diyarbakır watermelon juice on carbon tetrachloride-induced toxicity in rats.
Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves.
Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat.
S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice.
Studies on the antioxidant and hepatoprotective activities of polysaccharides from Talinum triangulare.
Zinc deficiency enhances sensitivity to carbon tetrachloride-induced hepatotoxicity in rats.
In vitro and in vivo antioxidant activity of Symplocos cochinchinensis S. Moore leaves containing phenolic compounds.
Hepatoprotective and antioxidant effects of porcine plasma protein hydrolysates on carbon tetrachloride-induced liver damage in rats.
Oral administration of Trapa taiwanensis Nakai fruit skin extracts conferring hepatoprotection from CCl4-caused injury.
Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum.
Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats.
Hepatoprotection of Graptopetalum paraguayense E. Walther on CCl₄-induced liver damage and inflammation.
Effects of standardized bilberry fruit extract (Mirtoselect®) on resolution of CCl4-induced liver fibrosis in mice.
[Preliminary investigation on the formation mechanism of CCL4-water-cetyl trimethyl ammonium bromide (CTAB) gel].
Protective effects of water extract of clam on normal and CCl₄-induced damage in primary cultured rat hepatocytes.
Evaluation of dispersive liquid-liquid microextraction for the simultaneous determination of chlorophenols and haloanisoles in wines and cork stoppers using gas chromatography-mass spectrometry.
The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2.
Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats.
Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in Sprague-Dawley rats.
Mushroom insoluble polysaccharides prevent carbon tetrachloride-induced hepatotoxicity in rat.
Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice.
Intestinal permeability assessed by 51Cr-EDTA in rats with CCl4 - induced cirrhosis.
Genomic indicators in the blood predict drug-induced liver injury.
Antioxidant and hepatoprotective effects of the methanol extract of the leaves of Satureja macrostema.
Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats.
Hepatoprotective effects of Ficus racemosa stem bark against carbon tetrachloride-induced hepatic damage in albino rats.
Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels.
Antioxidant and hepatoprotective potential of essential oils of coriander (Coriandrum sativum L.) and caraway (Carum carvi L.) (Apiaceae).
Prevention of CCl4-induced nephrotoxicity with Sonchus asper in rat.
Hepatoprotective effects of apple polyphenols on CCl4-induced acute liver damage in mice.
Effect of celecoxib, a selective cyclooxygenase-2 inhibitor on carbon tetrachloride intoxication in rats.
Enhancement of organ regeneration in animal models by a stem cell-stimulating plant mixture.
Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats.
Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome.
Protective effects of silica hydride against carbon tetrachloride-induced hepatotoxicity in mice.
Increasing early insulin secretion compensate adequately for hepatic insulin resistance in CCl4-induced cirrhosis rats.
Long-term treatment with shengmai san-derived herbal supplement (Wei Kang Su) enhances antioxidant response in various tissues of rats with protection against carbon tetrachloride hepatotoxicity.
TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators.
The immunological and chemical detection of N-(hexanoyl)phosphatidylethanolamine and N-(hexanoyl)phosphatidylserine in an oxidative model induced by carbon tetrachloride.
Protective effect of fermented sea tangle against ethanol and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats.
Protective effect of a coffee preparation (Nescafe pure) against carbon tetrachloride-induced liver fibrosis in rats.
Potential of long-term dietary administration of rosemary in improving the antioxidant status of rat tissues following carbon tetrachloride intoxication.
Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage.
In vitro and in vivo antioxidant properties and DNA damage protective activity of green fruit of Ficus glomerata.
Antimicrobial and cytotoxic constituents from leaves of Sapium baccatum.
Effects of Asparagus officinalis extracts on liver cell toxicity and ethanol metabolism.
Antioxidant and antigenotoxic activities of purple grape juice--organic and conventional--in adult rats.
Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats.
Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats.
Protective effect of Millettia reticulata Benth against CCl(4)-induced hepatic damage and inflammatory action in rats.
Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes.
Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo.
Carbon tetrachloride-induced liver disease in rats: the potential effect of supplement oils with vitamins E and C on the nutritional status.
Absorption of andrographolides from Andrographis paniculata and its effect on CCl(4)-induced oxidative stress in rats.
Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice.
Zizyphus spina-christi protects against carbon tetrachloride-induced liver fibrosis in rats.
Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice.
Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice.
Enhanced oral bioavailability and antioxidant profile of ellagic acid by phospholipids.
Neutral sphingomyelinase-induced ceramide accumulation by oxidative stress during carbon tetrachloride intoxication.
PEGylated lactoferrin enhanced its hepatoprotective effects on acute liver injury induced by carbon tetrachloride in rats.
Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats.
Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat.
Superfine saengshik improves liver protecting effect compared with fine saengshik in an animal model.
Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats.
The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats.
Methoxy VO-salen complex: in vitro antioxidant activity, cytotoxicity evaluation and protective effect on CCl4-induced oxidative stress in rats.
Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats.
Effect of alpha-tocopherol on carbon tetrachloride intoxication in the rat liver.
Development of a new animal model of liver cirrhosis in swine.
Protective effect of the Aralia continentalis root extract against carbon tetrachloride-induced hepatotoxicity in mice.
Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation.
Quantitative rat liver function test by galactose single point method.
A nutrient mixture suppresses carbon tetrachloride-induced acute hepatic toxicity in ICR mice.
Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation.
Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride.
Hepatoprotective activity of Amaranthus spinosus in experimental animals.
Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice.
Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats.
Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats.
Effect of long-term dietary administration of oregano on the alleviation of carbon tetrachloride-induced oxidative stress in rats.
Saengshik, a formulated health food, prevents liver damage in CCl4-induced mice and increases antioxidant activity in elderly women.
Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats.
Identification of superoxide dismutase as a potential urinary marker of carbon tetrachloride-induced hepatic toxicity.
Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats.
Efficient amelioration of carbon tetrachloride induced toxicity in isolated rat hepatocytes by Syzygium cumini Skeels extract.
Walnut polyphenols prevent liver damage induced by carbon tetrachloride and d-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut.
Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae.
Bees wax polyphenols as suppressor of CC1--induced oxidative stress in rats.
Characterization and bioavailability of liposomes containing a ukon extract.
Halogenated volatile organic compounds from the use of chlorine-bleach-containing household products.
Ameliorative action of cyanobacterial phycoerythrin on CCl(4)-induced toxicity in rats.
Invivo studies on evaluation of potential toxicity of unspent tannins using albino rats (Rattusnorvegicus).
Antioxidant activity of vinegar produced from distilled residues of the Japanese liquor shochu.
Corn oil enhancing hepatic lipid peroxidation induced by CCl4 does not aggravate liver fibrosis in rats.
Intake of purple grape juice as a hepatoprotective agent in Wistar rats.
Protective effects of purple grape juice on carbon tetrachloride-induced oxidative stress in brains of adult Wistar rats.
Toxicity of carbon tetrachloride to Dunaliella salina, an environmentally tolerant alga.
Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice.
New role of antinutritional factors, phytic acid and catechin in the treatment of CCl4 intoxication.
Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats.
Genotoxic effects of tanshinones from Hyptis martiusii in V79 cell line.
Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats.
One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats.
Preventive effect of D-002, a mixture of long-chain alcohols from beeswax, on the liver damage induced with CCl4 in rats.
Protective effect of some tropical vegetables against CCl4-induced hepatic damage.
Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice.
Increase of ceramide in the liver and plasma after carbon tetrachloride intoxication in the rat.
Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride.
Effect of the carotenoid-producing alga, Dunaliella bardawil, on CCl4-induced toxicity in rats.
Mathematical modelling of liver regeneration after intoxication with CCl(4).
Antioxidant and protective effect of an oleanolic acid-enriched extract of A. deliciosa root on carbon tetrachloride induced rat liver injury.
Influence of liver's oxide-reductive homeostasis disorder for AKBR values in rabbit's arterial blood.
Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies.
Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver.
The role of food restriction on CCl4-induced cirrhosis model in rats.
Study of potential systemic oxidative stress animal models for the evaluation of antioxidant activity: status of lipid peroxidation and fat-soluble antioxidants.
Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats.
Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties.
Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats.
Influence of various diet regimens on deterioration of hepatic function and hematological parameters following carbon tetrachloride: a potential protective role of natural honey.
Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice.
Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion.
Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats.
Protective effect of Dunaliella salina-A marine micro alga, against carbon tetrachloride-induced hepatotoxicity in rats.
Antioxidant potentials of flaxseed by in vivo model.
Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats.
Formation of Nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification.
Hepatoprotective effect of a hot-water extract from the edible thorny oyster Spondylus varius on carbon tetrachloride-induced liver injury in mice.
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis.
Isolation of an in vitro and ex vivo antiradical melanoidin from roasted barley.
Short-term dietary restriction modulates liver lipid peroxidation in carbon tetrachloride-intoxicated rats.
Comparative evaluation of hepatoprotective activity of carotenoids of microalgae.
Ginkgo biloba extract alleviates liver fibrosis induced by CCl in rats.
Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats.
The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats.
In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.
Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity.
Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats.
Preventive treatment with vitamin E alleviates the poisoning effects of carbon tetrachloride in cattle.
Hepatoprotective activity of Gundelia tourenfortii.
Determination of dipole moment in the ground and excited state by experimental and theoretical methods of N-nonyl acridine orange.
[Hepatoprotective properties of balm Herbamarin and hydrolysates from marine invertebrates in toxic hepatitis and ethanol intoxication].
[Improved test for the migration of antimony and germanium from polyethylene terephthalate].
In vivo antioxidant activity of carotenoids from Dunaliella salina--a green microalga.
[The active metabolite of leflunomide A771726 inhibits proliferation and collagen synthesis of hepatic stellate cell].
Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats.
The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride.
Hepatoprotective and antioxidant effects of Bupleurum kaoi Liu (Chao et Chuang) extract and its fractions fractionated using supercritical CO(2) on CCl(4)-induced liver damage.
Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis.
Concentration-dependent bifunctional effect of TGF-beta 1 on immunoglobulin production: a role for Smad3 in IgA production in vitro.
The effect of kefir on the activities of GSH-Px, GST, CAT, GSH and LPO levels in carbon tetrachloride-induced mice tissues.
Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury.
Beneficial effects of branched-chain amino acids on altered protein and amino acid metabolism in liver cirrhosis: evaluation in a model of liver cirrhosis induced in rats with carbon tetrachloride.
Protein deficiency and muscle damage in carbon tetrachloride induced liver cirrhosis.
Adsorption of volatile organic compounds by pecan shell- and almond shell-based granular activated carbons.
Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat.
Antioxidative and hepatoprotective effects of Antrodia camphorata extract.
[Effect of tea polyphenols and tea pigments on inducing the activity of phase II detoxicating enzymes and on the chemoprevention of liver precancerous lesions].
Food restriction attenuates blood lipid peroxidation in carbon tetrachloride-intoxicated rats.
Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systems.
Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats.
Rats made cirrhotic by chronic CCl4 treatment still exhibit anticipatory activity to a restricted feeding schedule.
Effect of dried fruits of Carica papaya Linn on hepatotoxicity.
Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver.
Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia and Nicotiana glauca.
[Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis].
Antioxidant activities of grape (Vitis vinifera) pomace extracts.
Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models.
Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity.
Effects of dietary protein of proso millet on liver injury induced by D-galactosamine in rats.
A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats.
Mechanisms of circadian rhythmicity of carbon tetrachloride hepatotoxicity.
Immunohistochemical localization of beta 1-adrenergic receptors in the liver of male and female F344 rat.
Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats.
Oxidative preconditioning affords protection against carbon tetrachloride-induced glycogen depletion and oxidative stress in rats.
Dielectric properties of some components of fruit aroma in carbon tetrachloride solution at 298.15 K.
Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver.
Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater.
Metallothionein expression protects against carbon tetrachloride-induced hepatotoxicity, but overexpression and dietary zinc supplementation provide no further protection in metallothionein transgenic and knockout mice.
Urinary aldehydes as indicators of lipid peroxidation in vivo.
Zaltoprofen prevents carbon tetrachloride-induced reduction of body weight in rats.
Response of urinary lipophilic aldehydes and related carbonyl compounds to factors that stimulate lipid peroxidation in vivo.
Polyamines and thiols in the cytoprotective effect of L-cysteine and L-methionine on carbon tetrachloride-induced hepatotoxicity.
Carbon tetrachloride treatment induces anorexia independently of hepatitis in rats.
Dimerumic acid as an antioxidant of the mold, Monascus anka.
Effect of food restriction on hepatotoxicity of carbon tetrachloride in rats.
Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis.
Determination of the wax ester content in olive oils. Improvement in the method proposed by EEC regulation 183/93.
Potentiation of paracetamol and carbon tetrachloride-induced hepatotoxicity in rodents by the food additive vanillin.
Interactions in sheep between tall fescue ergot alkaloids and hepatotoxic carbon tetrachloride and Senecio pyrrolizidine alkaloids.
Modulation of halobenzene-induced hepatotoxicity by DT-diaphorase modulators, butylated hydroxyanisole and dicoumarol: evidence for possible involvement of quinone metabolites in the toxicity of halobenzenes.
Thiols and polyamines in the cytoprotective effect of taurine on carbon tetrachloride-induced hepatotoxicity.
Increase of lipid hydroperoxides in liver mitochondria and inhibition of cytochrome oxidase by carbon tetrachloride intoxication in rats.
Possible modulatory effect of browned yam flour diet on chemically-induced toxicity in the rat.
In vivo protective role of Koflet (an ayurvedic preparation) against cellular toxicity caused by CCl4 and flyash.
Hepatoprotective effect of Liv-52 and kumaryasava on carbon tetrachloride induced hepatic damage in rats.
Free radical transients in photobleaching of xanthophylls and carotenes.
Involvement of polyamines in the protection of taurine against the cytotoxicity of hydrazine or carbon tetrachloride in isolated rat hepatocytes.
Application of physiologically based pharmacokinetic modelling to combination toxicology.
A pharmacokinetic model of anaerobic in vitro carbon tetrachloride metabolism.
Oral supplementation with branched-chain amino acids improves transthyretin turnover in rats with carbon tetrachloride-induced liver cirrhosis.
Differential expression of cysteine-rich intestinal protein in liver and intestine in CCl4-induced inflammation.
A review of the role of tissue repair as an adaptive strategy: why low doses are often non-toxic and why high doses can be fatal.
Appearance of oval cells in the liver of rats after long-term exposure to ethanol.
Depressed sensitivity of the hepatoportal NaCl receptors in rats with carbon tetrachloride-induced liver cirrhosis.
Ergosterol oxidation may be considered a signal for fungal growth and aflatoxin production in Aspergillus parasiticus.
Protein metabolism in cirrhotic rats: effect of dietary restriction.
Effects of dietary restriction on induction of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) in rat liver.
Formulation and analysis of food-grade mineral hydrocarbons in toxicology studies.
Determination of the iodine value of oils and fats: summary of collaborative study.
Enhanced teratogenic activity of di-n-butyltin diacetate by carbon tetrachloride pretreatment in rats.
Assessment of the carbon tetrachloride-induced cirrhosis model for studies of nitrogen metabolism in chronic liver disease.
Effects of diet restriction and carnitine on carbon tetrachloride toxicity in the rat.
Preventive effects of diphenyl dimethyl dicarboxylate on the immunotoxicity of carbon tetrachloride in ICR mice.
Import control of irradiated foods by the thermoluminescence method.
Reduction of liver taurine in rats by beta-alanine treatment increases carbon tetrachloride toxicity.
Carbon tetrachloride-induced alterations in hepatic glutathione and ascorbic acid contents in mice fed a diet containing ascorbate esters.
Low and marginal copper intake by postweanling rats: effects on copper status and resistance to carbon tetrachloride hepatotoxicity.
Improved high-performance liquid chromatographic procedure for the determination of lasalocid in chicken tissues and egg using polymeric and porous graphitic carbon columns.
Inflammation, an inducer of metallothionein, inhibits carbon-tetrachloride-induced hepatotoxicity in rats.
Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine.
Ethanol and food deprivation induced enhancement of hepatotoxicity in rats given carbon tetrachloride at low concentration.
Effects of short-term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition in the rat.
Chemoprotective and hepatic enzyme induction properties of indole and indenoindole antioxidants in rats.
Effects of moderate copper deficiency on carbon tetrachloride-induced hepatotoxicity in rats.
Intrinsic acute toxicity and hepatic enzyme inducing properties of the chemoprotectants indole-3-carbinol and 5,10-dihydroindeno[1,2-b]indole in mice.
Fumigants and related chemicals in foods: review of residue findings, contamination sources, and analytical methods.
[Chemical nature and biological activity of miliacine].
Enhanced lipid peroxidation is not necessary for induction of metallothionein-I by oxidative stress.
Taurine, a possible urinary marker of liver damage: a study of taurine excretion in carbon tetrachloride-treated rats.
Responses of antioxidants and lipid peroxidation in mussels to oxidative damage exposure.
[Pharmacological studies on puerariae flos. II. The effects of puerariae flos on alcohol-induced unusual metabolism and experimental liver injury in mice].
Phospholipid hydroperoxide accumulation in liver of rats intoxicated with carbon tetrachloride and its inhibition by dietary alpha-tocopherol.
The onset of sodium retention in experimental cirrhosis in rats is related to a critical threshold of liver function.
Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures.
Methylcellulose prevents the regression of carbon tetrachloride-induced liver fibrosis and cirrhosis in rats.
Free malondialdehyde determination by HPLC applied to microsomal studies.
Free radical inhibitor effect of retinol after carbon tetrachloride intoxication in the rat.
Cytoprotective effects of Gypsophila saponins towards isolated rat hepatocytes.
Combined effect of a PUFA deficient diet and iron levels on lipid peroxidation induced by CCl4.
Influence of ethanol pretreatment of differing duration on toxic effects of carbon tetrachloride in rats.
Effects of valine on 15N incorporation into serum and tissue protein and non-protein fractions following 15N-L-leucine administration to normal and liver-injured rats.
Correlation between behavioral and pathological changes in the evaluation of neurotoxicity.
The food-mutagens 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) initiate enzyme-altered hepatic foci in the resistant hepatocyte model.
[Effects of supplementation with branched-chain amino acids on protein-nutritional status in rats treated by carbon tetrachloride].
Damage to protein synthesis concurrent with lipid peroxidation in rat liver slices: effect of halogenated compounds, peroxides, and vitamin E1.
[Rapeseed in experimental cirrhosis in the rat].
[A supplement with poly-unsaturated nutrients in the development and stabilization of the rat brain].
Determination of fumigants in cereals and cereal products by capillary gas chromatography.
Rapid determination of fumigant and industrial chemical residues in food.
Protection against carbon tetrachloride hepatotoxicity by 5,10-dihydroindeno[1,2-b]indole, a potent inhibitor of lipid peroxidation.
[Effect of a food ration with a low-protein content on the processes of liver parenchyma recovery in rats after tetrachloromethane damage].
Effect of branched-chain amino acid on 15N incorporation into liver and skeletal muscle proteins following [15N]-ammonium chloride administration to carbon tetrachloride-intoxicated rats.
Determining multifumigants in whole grains and legumes, milled and low-fat grain products, spices, citrus fruit, and beverages.
Determination of several halogenated fumigants in cereal products by steam distillation and capillary gas chromatography with electron capture detection.
Purge and trap method for determination of volatile halocarbons and carbon disulfide in table-ready foods.
Halogenated compounds as inducers of lipid peroxidation in tissue slices.
The study of mutagenic activity of carcinogens and other chemical agents with Salmonella typhimurium assays: testing of 126 compounds.
Comparison of the behavioral effects of neurotoxic and systemically toxic agents: how discriminatory are behavioral tests of neurotoxicity?
Effect of endrin and endrin derivatives on hepatobiliary function and carbon tetrachloride-induced hepatotoxicity in male and female rats.
[Effects of one-day food restriction on the metabolism and toxicity of organic solvents in rats].
Synergistic neurotoxicity of carbon tetrachloride/carbon disulfide (80/20 fumigants) and other pesticides in grain storage workers.
Orotic acid, arginine, and hepatotoxicity.
[Mutagenic activity of carcinogens and other chemical agents in Salmonella typhimurium tests].
Extraction of light filth from unground marjoram: collaborative study.
Rapid thin layer chromatographic determination of aflatoxin M1 in powdered milk.
Propionate loading test for liver function during experimental liver necrosis in sheep.
Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study.
Evaluation of liver weight changes following a single oral administration of carbon tetrachloride in rats.
Bioactivation and bound residues.
Effect of lipid-protein interactions on extrusion of offal protein isolates.
Dietary carbohydrate-and ethanol-induced alteration of the metabolism and toxicity of chemical substances.
Food and drug interactions.
Protective role of dietary butylated hydroxyanisole against chemical-induced acute liver damage in mice.
Effect of indole on N-nitrosodimethylamine demethylase in rats treated with carbon tetrachloride.
Thin layer chromatographic determination of aflatoxins in dry ginger root and ginger oleoresin.
Modification of the AOAC method for determination of fumigants in wheat.
Influence of dietary manipulations on rat kidney gluconeogenesis during acute intoxication with carbon tetrachloride.
Carbon tetrachloride.
Studies related to nitrosamide formation: nitrosation in solvent: water and solvent systems, nitrosomethylurea formation in the rat stomach and analysis of a fish product for ureas.
The toxicity of chloroform as determined by single and repeated exposure of laboratory animals.
The transplacental migration and accumulation in blood of volatile organic constituents.
Tolerance and acceptable daily intake of chlorinated fumigants in the rat diet.
Carcinogenesis bioassay of trichloroethylene.
A study of kinetic parameters for the use of serum ornithine carbamoyltransferase as an index of liver damage.
Identification of the major thermal degradation products of the insecticide mirex.
The temperature effect on fumigant descrption from cereal grain.
Hexachlorobenzene contamination: its effects in a Louisiana population.
Fumigant residues of carbon tetrachloride, ethylene dichloride, and ethylene dibromide in wheat, flour, bran, middlings, and bread.
Carbon tetrachloride in defence and attack.
Simulated field blood studies in the bottle-nosed dolphin Tursiops truncatus. 2. Effects of stress on some hematologic and plasma chemical parameters.
Fate of EDC-CCl 4 (75:25) residues during milling and oil extraction of soybeans.
The effect of diet and drugs on hepatic microsomal aminopyrine N-demethylase activity in vitro and susceptibility to carbon tetrachloride in sheep.
Correlation between serum enzymes, isozyme patterns and histologically detectable organ damage.
Effects of carbon tetrachloride on the metabolism of liver glycogen in the rat.
Toxicological evaluation of some combination of food preservatives.
Carbon tetrachloride.
Cytochrome p450: the tip of another iceberg.
Carbon tetrachloride hepatotoxicity: seeing the wood through the trees.
Microsomes, metabolism and toxicity.
[Alcohol and liver disorders].
Canadian Food and Drug viewpoint on pesticide tolerances.
Food additives and chemical carcinogens: on the concept of zero tolerance.
Liver response tests. 8. Factors influencing the activities of liver-microsomal phosphatases.
Functional identity of rat-liver microsomal glucose 6-phosphatase and inorganic pyrophosphatase.
Liver response tests. VI. Application to a comparative study of food antioxidants and hepatotoxic agents.
Liver response tests. I. Exploratory studies on glucose 6-phosphatase and other liver enzymes.
ACUTE LIVER INJURY IN DUCKLINGS AS A RESULT OF AFLATOXIN POISONING.
Evaluation of potential health hazards in fumigation of shelled corn with a mixture of carbon disulfide and carbon tetrachloride.
INFLUENCE OF DIETARY FACTORS AND SEX ON THE TOXICITY OF CARBON TETRACHLORIDE IN RATS.
Effects of Yeast and Food Intake on Experimental carbon Tetrachloride Cirrhosis of the Liver in the Rat.

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KEGG (GenomeNet):	C07561
HMDB (The Human Metabolome Database):	HMDB31330
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Formulations/Preparations: •usepaopp pesticide code 016501; trade names: acritet (use 2 code nos. 000601 and 016501), ventox (use 2 code nos. 000601 and 016501). •used in combination, 80% carbon tetrachloride & 20% carbon disulfide mixture, these two fumigants form one of the most commonly & effectively used liq fumigant formulations. •grades or purity: commercial; technical; usp. •granosan: disinfectant composed of 30% carbon tetrachloride and 70% ethylene dichloride. •grades: technical; cp; electronic •carbon tetrachloride + carbon disulfide; carbon tetrachloride + ethylene dibromide + ethylene dichloride ... •liquid form, reagent, acs and spectrophtometric grades.

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American Elements

Sigma-Aldrich

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	153.81900024414
Specific gravity	@ 25 °C
Pounds per Gallon
Vapor Pressure	115 mmHg @ 25 °C
Vapor Density	5.32
Flash Point TCC Value	-0.3 °C TCC
logP (o/w)	2.83
Solubility
water, 793 mg/L @ 25 °C (exp)	Yes

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-chicken LD50 4497 mg/kg GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: OTHER CHANGES British Veterinary Journal. Vol. 127, Pg. 304, 1971. intraperitoneal-dog LD50 1500 mg/kg LIVER: LIVER FUNCTION TESTS IMPAIRED Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967. intravenous-dog LDLo 125 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. oral-dog LDLo 1000 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. oral-guinea pig LD50 5760 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 32, 1968. oral-mammal (species unspecified) LD50 6000 mg/kg Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988. oral-man LDLo 429 mg/kg LUNGS, THORAX, OR RESPIRATION: CYANOSIS KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS CARDIAC: CHANGE IN RATE Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. Vol. 19, Pg. 781, 1973. unreported-man LDLo 93 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man TDLo 1700 mg/kg BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES South African Medical Journal. Vol. 49, Pg. 635, 1975. intraperitoneal-mouse LD50 572 mg/kg Pharmacologist. Vol. 10, Pg. 172, 1968. oral-mouse LD50 8263 mg/kg Journal of Pharmacy and Pharmacology. Vol. 3, Pg. 169, 1951. intravenous-rabbit LD50 5840 mg/kg BEHAVIORAL: EXCITEMENT BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie. Vol. 118, Pg. 305, 1974. oral-rabbit LD50 5760 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 32, 1968. intraperitoneal-rabbit LDLo 477 mg/kg Gastroenterology. Vol. 71, Pg. 118, 1976. intraperitoneal-rat LD50 1500 uL/kg U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. MDDC-1715 oral-rat LD50 2350 mg/kg Archives of Toxicology. Vol. 54, Pg. 275, 1983. intratracheal-rat LDLo 90 mg/kg National Technical Information Service. Vol. OTS0520615
Dermal Toxicity:
subcutaneous-cat LDLo 300 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: HEMORRHAGE LIVER: FATTY LIVER DEGERATION Journal of Pharmacology and Experimental Therapeutics. Vol. 63, Pg. 153, 1938. skin-guinea pig LD50 > 9400 uL/kg Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965. subcutaneous-mouse LD50 31000 mg/kg BEHAVIORAL: ATAXIA BEHAVIORAL: SLEEP Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958. skin-rabbit LD50 > 20000 mg/kg Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 712, 1992. subcutaneous-rabbit LDLo 3000 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. skin-rat LD50 5070 mg/kg Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 16, 1978.
Inhalation Toxicity:
inhalation-cat LCLo 38110 ppm/2H "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1405, 1935. inhalation-dog LCLo 14620 ppm/8H BEHAVIORAL: GENERAL ANESTHETIC VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. inhalation-frog LCLo 58000 mg/m3 Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 97, Pg. 86, 1923. inhalation-guinea pig LCLo 20000 ppm/2H Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967. inhalation-human LCLo 1000 ppm Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 198, 1966. inhalation-human LCLo 5 pph/5M Tabulae Biologicae. Vol. 3, Pg. 231, 1933. inhalation-human TCLo 20 ppm GASTROINTESTINAL: NAUSEA OR VOMITING "Chemistry of Industrial Toxicology," 2nd ed., Elkins, H.B., New York, John Wiley & Sons, Inc., 1959Vol. 2, Pg. 136, 1959. inhalation-human TCLo 45 ppm/3D BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Lancet. Vol. 1, Pg. 360, 1960. inhalation-human TCLo 317 ppm/30M GASTROINTESTINAL: NAUSEA OR VOMITING JAMA, Journal of the American Medical Association. Vol. 103, Pg. 962, 1934. inhalation-mammal (species unspecified) LC50 34500 mg/m3 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 17, 1980. inhalation-mouse LC50 9526 ppm/8H Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 382, 1947. inhalation-rat LC50 8000 ppm/4H Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 16, 1974.

Safety in use information

Category:
indirect food additives: adhesives and components of coatings
Recommendation for carbon tetrachloride usage levels up to:
	not for fragrance use.

Recommendation for carbon tetrachloride flavor usage levels up to:
	not for flavor use.