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dextro-glucurolactone

Chemical Structure

General Material Information

Preferred name dextro-glucurolactone
Trivial Name Glucuronolactone
Short Description beta-D-anhydroglucuronate
Formula C6 H8 O6
CAS Number 32449-92-6
ECHA Number 251-053-3
FDA UNII XE4Y3016M9
Nikkaji Number J3.805I
Beilstein Number 0083595
MDL MFCD00135622
xLogP3-AA -1.80 (est)
Bio Activity Summary External link
NMR Predictor External link
Synonyms
  • beta-D- anhydroglucuronate
  • beta-dextro- anhydroglucuronate
  • dicurone
  • (2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
  • (2R)-[(2S,3R,4S)-3,4-dihydroxy-5-oxotetrahydrofuran-2-yl](hydroxy)acetaldehyde
  • glucofuranurono-6,3-lactone
  • D- glucurolactone
  • D- glucuronic acid lactone
  • D- glucurono-3,6-lactone
  • D- glucurono-6,3-lactone
  • dextro- glucurono-6,3-lactone
  • D- glucurono-gamma-lactone
  • dextro- glucurono-gamma-lactone
  • D- glucuronolactone
  • (2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
  • D-Glucuronic acid, γ-lactone
  • Glucuronic acid, γ-lactone, D-
  • Glucurone
  • Glucuronolactone
  • Glucurolactone
  • D-Glucuronolactone
  • D-Glucurono-γ-lactone
  • D-Glucurono-6,3-lactone
  • Glucuronic acid γ-lactone
  • Glucoxy
  • Guronsan
  • Glycurone
  • Reulatt S.S.
  • Glucuronosan
  • D-Glucurono-3,6-lactone
  • D-Glucuronic acid lactone
  • D-Glucofuranurono-6,3-lactone
  • Glucurono-6,3-lactone
  • NSC 656
  • D-Glucuronic acid γ-lactone

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C02670
HMDB (The Human Metabolome Database):HMDB06355
FooDB:FDB023903
Export Tariff Code:2932.29.5050
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 176.12495422363
Melting Point 174 to 178°C @ 760 mm Hg
Boiling Point 403 to 404°C @ 760 mm Hg
Flash Point TCC Value 174.44 °C TCC
logP (o/w) -3.457 est
Solubility
alcohol Yes
water, 257000 mg/L @ 21C (exp) Yes

Organoleptic Properties

Odor Type: Mentholic
mentholic
Odor strength low
General comment At 100.00 %. very mild mentholic

Potential Uses

Applications
Other purposes Skin conditioning
Cosmetic purposes Skin conditioning

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 10700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-rat LD50 3200 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-rabbit LD50 940 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

oral-mouse LD50 > 20000 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-mouse LD50 4568 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intraperitoneal-mouse LD50 5797 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-dog LD50 940 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

Dermal Toxicity:
subcutaneous-rat LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-rabbit LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-mouse LD50 8210 ul/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-cat LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-dog LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
special dietary and nutritional additives
Recommendation for dextro-glucurolactone usage levels up to:
not for fragrance use.
Recommendation for dextro-glucurolactone flavor usage levels up to:
not for flavor use.

Safety references

European Food Safety Authority (EFSA) reference(s):

The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks
View page or View pdf

Gathering consumption data on specific consumer groups of energy drinks
View page or View pdf

Scientific Opinion on the safety of caffeine
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):32449-92-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :92283
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
Chemidplus:0032449926
RTECS:LZ8930000 for cas# 32449-92-6