diethyl amine

General Material Information

Preferred name	diethyl amine
Trivial Name	Diethylamine
Short Description	2,2'-diethylamine
Formula	C4 H11 N
CAS Number	109-89-7
ECHA Number	203-716-3
FDA UNII	B035PIS86W
Nikkaji Number	J807I
Beilstein Number	0605268
MDL	MFCD00009032
COE Number	10470
Bio Activity Summary	External link
NMR Predictor	External link
Synonyms	diethylamine 2,2'- diethylamine diethylamine [UN1154] [Flammable liquid] N- ethylethanamine Ethanamine, N-ethyl- N-Ethylethanamine N,N-Diethylamine DEA

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Literature & References

	N-ethylethanamine
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	109-89-7
Pubchem (cid):	8021
Pubchem (sid):	134974008
Pherobase:	View

Publications by PubMed
Systematic analysis of the ability of Nitric Oxide donors to dislodge biofilms formed by Salmonella enterica and Escherichia coli O157:H7.
[Determination of enantiomeric impurity of timolol maleate in bulk substances and eye drops].
Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization.
Microwave-assisted extraction and determination of cyanuric acid residue in pet food samples by liquid chromatography-tandem mass spectrometry.
Determination of melamine and its analogues in egg by gas chromatography-tandem mass spectrometry using an isotope dilution technique.
Chiral stationary phases for separation of intermedine and lycopsamine enantiomers from Symphytum uplandicum.
Determination of sulfonamides in swine muscle after salting-out assisted liquid extraction with acetonitrile coupled with back-extraction by a water/acetonitrile/dichloromethane ternary component system prior to high-performance liquid chromatography.
[Determination of melamine and cyanuric acid in milk by gas chromatography-mass spectrometry].
Simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography-tandem mass spectrometry.
Simultaneous determination of azaperone and azaperol in animal tissues by HPLC with confirmation by electrospray ionization mass spectrometry.
Diagnostic determination of melamine and related compounds in kidney tissue by liquid chromatography/tandem mass spectrometry.
Selective separation of the major whey proteins using ion exchange membranes.
Alkynyl polysaccharides: synthesis of propargyl potato starch followed by subsequent derivatizations.
A simple and rapid method for simultaneous determination of benzoic and sorbic acids in food using in-tube solid-phase microextraction coupled with high-performance liquid chromatography.
HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.
Synthesis of diethylamine-functionalized soybean oil.
Mammary blood flow does not limit milk yield in lactating goats.
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
Biological action of nitric oxide donor compounds on platelets from patients with sickle cell disease.
The analysis of beta-agonists by packed-column supercritical fluid chromatography with ultra-violet and atmospheric pressure chemical ionisation mass spectrometric detection.
Dietary secondary amines and liver hepatoma in Port Harcourt, Nigeria.
Local secretion of nitric oxide and the control of mammary blood flow.
Effects of food, ceruletide and ranitidine on the pharmacokinetics of the oral cephalosporin S-1108 in humans.
Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India).
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion.
Determination of aliphatic amines in air by on-line solid-phase derivatization with HPLC-UV/FL.
[The effect of lysine-enriched bread on the formation of N-nitrosamines from their precursors in the stomach of dogs].
Ion-pair reverse-phase liquid chromatographic determination of amprolium in complete feeds and premixes.
Possible underestimation of nitrosatable amine levels in artificial saliva extracts of children's rubber pacifiers and baby-bottle teats.
The effect of food and time of administration on the absorption of diethylamine chromocarbe.
Abundance of dimethylamine in seafoods: possible implications in the incidence of human cancer.
Mutagenicity of pyrolysates from guanidine, ureide, secondary amines and polyamines found by the Salmonella/mammalian-microsome test.
Failure to induce tumours in guinea-pigs after concurrent administration of nitrite and diethylamine.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:	View
CHEBI:	View
CHEMBL:	View
UM BBD:	Search
HMDB (The Human Metabolome Database):	Search
FooDB:	FDB005767
Export Tariff Code:	2921.19.1100
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: •98.5% minimum purity •grade of purity: technical: 99%

Suppliers

BASF	Capot Chemical
Eastman Chemical	EMD Millipore
Penta International	Santa Cruz Biotechnology
Sarchem Laboratories	Sigma-Aldrich
Silver Fern Chemical	Taminco (Eastman)
TCI AMERICA	Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	73.138671875
Specific gravity	@ 20 °C
Pounds per Gallon	5.865 to 5.898
Refractive Index	1.383 to 1.387 @ 20 °C
Melting Point	-5 to -4.5°C @ 760 mm Hg
Boiling Point	55 to 58°C @ 760 mm Hg
Vapor Pressure	237 mmHg @ 25 °C
Vapor Density	2.5
Flash Point TCC Value	-27.78 °C TCC
logP (o/w)	0.58
Solubility
water, 4.369e+005 mg/L @ 25 °C (est)	Yes
water, 1.00E+06 mg/L @ 25 °C (exp)	Yes

Organoleptic Properties

Odor Type: Ammoniacal
fishy, ammoniacal
General comment	At 0.10 % in dipropylene glycol. fishy ammoniacal

Occurrences

Potential Uses

Applications	indirect food additives: adhesives and components of coatings
Other purposes	Buffering agents
Cosmetic purposes	Buffering agents, Fragrance, Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
F - Highly flammable.
R 11 - Highly flammable. R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R 35 - Causes severe burns. S 01/02 - Keep locked up and out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 03/09 - Keep in cool, well-ventilated place. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 540 mg/kg Archives of Environmental Health. Vol. 1, Pg. 343, 1960. intraperitoneal-rat LDLo 50 mg/kg Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968. oral-mouse LD50 500 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: SLEEP Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985. intraperitoneal-mouse LD50 585 mg/kg Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
Dermal Toxicity:
skin-rabbit LD50 820 ul/kg AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
Inhalation Toxicity:
inhalation-rat LC50 4000 ppm/4H Archives of Environmental Health. Vol. 1, Pg. 343, 1960. inhalation-rabbit LC50 20 gm/m3 "Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960Vol. - inhalation-mammal (species unspecified) LC50 5000 mg/m3 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975. inhalation-mouse LCLo 3000 mg/m3/2H LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: FATTY LIVER DEGERATION BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 20(4), Pg. 28, 1955. inhalation-rabbit LCLo 20000 mg/m3 SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LIVER: FATTY LIVER DEGERATION LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA "Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960Vol. -, Pg. 176, 1960.

Safety in use information

Category:
indirect food additives: adhesives and components of coatings
Recommendation for diethyl amine usage levels up to:
	not for fragrance use.

Recommendation for diethyl amine flavor usage levels up to:
	not for flavor use.