dextro,laevo-homatropine hydrobromide

General Material Information

Preferred name	dextro,laevo-homatropine hydrobromide
Trivial Name	Homatropine hydrobromide
Short Description	homatropine DL- hydrobromide
Formula	C16 H22 Br N O3
CAS Number	51-56-9
ECHA Number	200-105-3
FDA UNII	BEW7469QZ0
MDL	MFCD00012676
Bio Activity Summary	External link
NMR Predictor	External link
Synonyms	(+-)-homatropine bromide (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide 1alphaH,5alphaH- tropan-3alpha-ol mandelate (ester) hydrobromide benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide (1:1) benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, HBr, endo-(+-) benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide, endo-(+-)- homatropine (bromhydrate d') homatropine DL-hydrobromide dextro, laevo-homatropine hydrobromid Benzeneacetic acid, α-hydroxy-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide (1:1) 1αH,5αH-Tropan-3α-ol, mandelate (ester), hydrobromide Benzeneacetic acid, α-hydroxy-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide, endo- Benzeneacetic acid, α-hydroxy-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide Homatropine hydrobromide Mandelic acid tropine ester hydrobromide (±)-Homatropine bromide Homatropine bromide Isopto Homatropine

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Literature & References

	(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	5821
Pubchem (sid):	134972439

Publications by PubMed
The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults.
Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE.
Interference of mandelic acid with the determination of homatropine hydrobromide by second-order derivative spectroscopy.
Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomy.
Determination of homatropine hydrobromide in eye drops by second-order derivative spectroscopy.
[Correction of the symptoms of late substance withdrawal syndrome by intra-conjunctival administration of 5% homatropine solution (preliminary report)].
An evaluation of the effectiveness of intramuscular atropine or homatropine eyedrops in preventing the effects of physostigmine eyedrops on human vision.
Effect of urea on the activity of certain ophthalmic drugs in man.
Memo on medications: atropine sulfate and homatropine hydrobromide: common mydriatic/cycloplegic agents.
Relapsing polychondritis in a Latin American man.
[Photometric determination of homatropine hydrobromide in eyedrops].
[Cycloplegia and residual accommodation (author's transl)].
[Homatropine hydrobromide].
Stability determination of homatropine hydrobromide by direct cerimetric titration.
HOMATROPINE HYDROBROMIDE. EFFECT OF TOPICAL ADMINISTRATION UPON THE INTRAOCULAR PRESSURE AND AQUEOUS FACILITY VALUES OF NORMAL AND CHRONIC SIMPLE GLAUCOMATOUS EYES.
[Use of a 4 per cent solution of homatropine hydrobromide for the determination of refraction in young patients].
Ophthalmic vehicles: the effect of methylcellulose on the penetration of homatropine hydrobromide through the cornea.
Effects of atropine sulfate, methylatropine nitrate (metropine) and homatropine hydrobromide on adult human eyes.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2933.99.9700
ChemSpider:	View

Suppliers

BOC Sciences	ExtraSynthese
Glentham Life Sciences	Santa Cruz Biotechnology
Sigma-Aldrich	TCI AMERICA
Glentham Life Sciences Ltd

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	356.25994873047
Flash Point TCC Value	N/a
Solubility
water, 1.49E+05 mg/L @ 25 °C (exp)	Yes
water, 2.042e+004 mg/L @ 25 °C (est)	Yes

Safety Information

Safety information

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 107 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 96, Pg. 1, 1949. intraperitoneal-rat LD50 154 mg/kg Drugs in Japan Vol. 6, Pg. 789, 1982.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
pharmaceuticals / chemical synthisis
Recommendation for dextro,laevo-homatropine hydrobromide usage levels up to:
	not for fragrance use.

Recommendation for dextro,laevo-homatropine hydrobromide flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):51-56-9

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :5821

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide

Chemidplus:0000051569

RTECS:YM5602000 for cas# 51-56-9