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histamine

Chemical Structure

General Material Information

Preferred name histamine
Trivial Name Histamine
Short Description 2-(1H-imidazol-5-yl)ethanamine
Formula C5 H9 N3
CAS Number 51-45-6
Deleted CAS Number 64422-25-9
ECHA Number 200-100-6
FDA UNII 820484N8I3
Nikkaji Number J4.117C
Beilstein Number 0002012
MDL MFCD00005210
Bio Activity Summary External link
NMR Predictor External link
Synonyms
  • 1H-imidazole-4-ethanamine
  • 2-imidazol-4-yl ethyl amine
  • 2-imidazol-4-yl ethylamine
  • 2-(1H-imidazol-5-yl)ethanamine
  • 2-(4-imidazolyl)ethylamine
  • 4-(2-aminoethyl)-1H-imidazole
  • 5-imidazoleethylamine
  • beta-aminoethylglyoxaline
  • beta-aminoethylimidazole
  • beta-imidazolyl-4-ethylamine
  • ergamine
  • ergotidine
  • ethylamine, 2-imidazol-4-yl-
  • imidazole, 4-(2-aminoethyl)-
  • istamina
  • theramine
  • 1H-Imidazole-5-ethanamine
  • Eramin
  • 5-Imidazoleethylamine
  • Imidazole-4-ethylamine
  • β-Imidazolyl-4-ethylamine
  • 4-(2-Aminoethyl)imidazole
  • 2-(1H-Imidazol-4-yl)ethylamine
  • 2-(4-Imidazolyl)ethanamine
  • 2-(1H-Imidazol-5-yl)ethylamine
  • 2-(1H-Imidazol-4-yl)ethanamine
  • NSC 33792
  • 2-(3H-Imidazol-4-yl)ethylamine
  • 2-(1H-Imidazol-5-yl)ethan-1-amine
  • 2-(1H-Imidazol-4-yl)ethan-1-amine
  • 4-Imidazoleethanamine
  • MeSH ID: D006632

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00388
HMDB (The Human Metabolome Database):HMDB00870
FooDB:FDB012596
YMDB (Yeast Metabolome Database):YMDB01556
Export Tariff Code:2933.29.5000
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
histamine phosphate, usp, & histamine dihydrochloridehistamine phosphate injection, usp, contains 1 mg of salt (0.36 mg of histamine base) in 1 ml. other avail prepn contain 0.275 & 2.75 mg of histamine phosphate in 1 ml (0.1 & 1 mg of histamine base in 1 ml), & are packaged in 1- or 5-ml ampules.

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 111.14772796631
Flash Point TCC Value 180.3 °C TCC
logP (o/w) -0.7
Solubility
water, 1e+006 mg/L @ 25 °C (est) Yes

Occurrences

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 7 mg/kg
CARDIAC: OTHER CHANGES
Indian Veterinary Journal. Vol. 57, Pg. 31, 1980.

intraperitoneal-guinea pig LD50 5 mg/kg
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 736, 1948.

intravenous-guinea pig LD50 180 ug/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 45, 1949.

oral-guinea pig LDLo 200 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.

intraperitoneal-mouse LD50 725 mg/kg
British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 137, 1961.

intravenous-mouse LD50 385 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.

oral-mouse LD50 220 mg/kg
Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.

intravenous-rabbit LDLo 2 mg/kg
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 784, 1948.

intravenous-rat LD50 630 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.

Dermal Toxicity:
subcutaneous-cat LDLo 34 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.

subcutaneous-dog LDLo 28500 ug/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: COMA
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.

subcutaneous-frog LDLo 1700 mg/kg
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.

subcutaneous-guinea pig LDLo 8 mg/kg
Farmaco, Edizione Scientifica. Vol. 9, Pg. 379, 1954.

subcutaneous-mouse LD50 2500 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.

subcutaneous-rabbit LDLo 12 mg/kg
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.

subcutaneous-rat LDLo 250 mg/kg
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
natural substances and extractives
Recommendation for histamine usage levels up to:
not for fragrance use.
Recommendation for histamine flavor usage levels up to:
not for flavor use.

Safety references

European Food Safety Authority (EFSA) reference(s):

Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf

Assessment of the incidents of histamine intoxication in some EU countries
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):51-45-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :774
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(1H-imidazol-5-yl)ethanamine
Chemidplus:0000051456
RTECS:MS1050000 for cas# 51-45-6