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isopropyl amine

Chemical Structure

General Material Information

Preferred name isopropyl amine
Trivial Name Isopropylamine
Short Description isopropylamine
Formula C3 H9 N
CAS Number 75-31-0
Deleted CAS Number 85404-24-6
FEMA Number 4238
Flavis Number 11.018
ECHA Number 200-860-9
FDA UNII P8W26T4MTD
Nikkaji Number J1.451F
Beilstein Number 0605259
MDL MFCD00008082
COE Number 10480
xLogP3-AA 0.10 (est)
NMR Predictor External link
JECFA Food Flavoring 1581 isopropylamine
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 75-31-0 ; ISOPROPYLAMINE
Synonyms
  • 1-amino-2-methylethane
  • 2-amino-propaan
  • 2-amino-propane
  • 2-amino-propano
  • 2-aminopropane
  • 1-methyl ethyl amine
  • 1-methylethyl amine
  • propan-2-amine
  • 2-propanamine
  • 2-propane amine
  • propane, 2-amino-
  • 2-propaneamine
  • 2-propyl amine
  • monoiso propyl amine
  • sec- propyl amine
  • 2-propylamine
  • iso propylamine
  • sec- propylamine
  • iso propylamine natural 5% in ethyl alcohol
  • 2-Propanamine
  • Isopropylamine
  • 2-Aminopropane
  • Monoisopropylamine
  • 2-Propylamine
  • sec-Propylamine
  • 1-Methylethylamine
  • NSC 62775
  • Propan-2-ylamine
  • 2-Isopropylamine

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

propan-2-amine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:75-31-0
Pubchem (cid):6363
Pubchem (sid):134970892
Publications by Info
aliphatic and aromatic amines and amides
Publications by US Patents
8,075,937 - Alkyldienamides exhibiting taste and sensory effect in flavor compositions

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C06748
HMDB (The Human Metabolome Database):Search
FooDB:FDB009650
Export Tariff Code:2921.19.6190
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 59.111728668213
Specific gravity @ 25 °C
Pounds per Gallon 5.717 to 5.766
Refractive Index 1.367 to 1.373 @ 20 °C
Melting Point -101 to -99°C @ 760 mm Hg
Boiling Point 32 to 34°C @ 760 mm Hg
Vapor Pressure 607.728027 mmHg @ 25 °C
Vapor Density 2.04
Flash Point TCC Value -32.22 °C TCC
logP (o/w) 0.26
Solubility
alcohol Yes
water, 8.381e+005 mg/L @ 25 °C (est) Yes
water, 1.00E+06 mg/L @ 25 °C (exp) Yes

Organoleptic Properties

Odor Type: Fishy
fishy, ammoniacal
General comment At 0.10 % in propylene glycol. fishy ammoniacal

Occurrences

Potential Uses

Applications
Odor purposes Fruit
Flavoring purposes Cereal, Cheese, Dairy, Fish, Meat
Other purposes Buffering agents
Cosmetic purposes Buffering agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 12 - Extremely flammable.
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 111 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: OTHER CHANGES
National Technical Information Service. Vol. OTS0542011

oral-guinea pig LD50 2700 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.

oral-mouse LD50 2200 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.

oral-rabbit LD50 3200 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.

unreported-mammal (species unspecified) LD50 500 mg/kg
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

intraperitoneal-rat LDLo 50 mg/kg
Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968.

Dermal Toxicity:
skin-rabbit LD50 380 mg/kg
Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974

Inhalation Toxicity:
inhalation-rat LC50 4000 ppm/4H
Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974

inhalation-mammal (species unspecified) LC50 1800 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

inhalation-mouse LCLo 7000 ppm/40M
Shell Chemical Company. Unpublished Report. Vol. -, Pg. 7, 1961.

Safety in use information

Category:
flavoring agents
Recommendation for isopropyl amine usage levels up to:
not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.02 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 340 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
Click here to view publication 22
average usual ppmaverage maximum ppm
baked goods: 2.0000010.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: 0.200001.00000
cheese: 0.400002.00000
chewing gum: --
condiments / relishes: 0.100000.50000
confectionery froastings: 1.000005.00000
egg products: --
fats / oils: 0.100000.50000
fish products: 0.200001.00000
frozen dairy: 0.400002.00000
fruit ices: 0.400002.00000
gelatins / puddings: --
granulated sugar: --
gravies: 0.100000.50000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 0.200001.00000
milk products: 0.400002.00000
nut products: --
other grains: 0.200001.00000
poultry: 0.200001.00000
processed fruits: 0.400002.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 0.100000.50000
snack foods: 1.000005.00000
soft candy: --
soups: 0.100000.50000
sugar substitutes: --
sweet sauces: --
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): --
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):75-31-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6363
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1221
WGK Germany:1
propan-2-amine
Chemidplus:0000075310
EPA/NOAA CAMEO:hazardous materials
RTECS:75-31-0